Article(id=1291404697626206608, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404681641713991, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.07.026, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729958400000, receivedDateStr=2024-10-27, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824473052, onlineDateStr=2026-08-04, pubDate=1744819200000, pubDateStr=2025-04-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824473052, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824473052, creator=13701087609, updateTime=1785824473052, updator=13701087609, issue=Issue{id=1291404681641713991, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='7', pageStart='901', pageEnd='1050', issueExtLink='null', onlineDate='null', pubDate='1744819200000', pubDateStr='2025-04-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824469242, creator='13701087609', updateTime=1785824469242, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1044, endPage=1050, ext={EN=ArticleExt(id=1291404697810755985, articleId=1291404697626206608, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical research status of PCSK9 inhibitors, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Low density lipoprotein cholesterol (LDL-C) is a pathogenic risk factor for atherosclerotic cardiovascular disease (ASCVD), so domestic and international guidelines recommend strict management of its level. Statins are the cornerstone of lipid-lowering therapy, however, some patients are still unable to achieve LDL-C target with moderate doses of statins. There is a 6% effect of statins, so combination with a novel lipid-lowering drugs is needed. Proprotein convertase chymotrypsin 9 (PCSK9) inhibitors are currently novel lipid-lowering drugs, which further reduce LDL-C levels in plasma by lowering the level or inhibiting the function of PCSK9 in vivo, thus playing a role in regulating blood lipids and reversing atherosclerotic plaques. The PCSK9 inhibitors currently used in clinical application in China include eloeu monoclonal antibody, aliskiren monoclonal antibody and inksilan, etc. This article briefly describes the classification of PCSK9 inhibitors and related clinical studies and summarizes the current research status of PCSK9 inhibitors in regulating blood lipids and affecting atherosclerotic plaques.

, authors=Yan-rong FENG¹, Xiao-yu LIU², Tian HAO¹, Rui DONG¹, Cen-yu WANG¹, Jing-hong ZHANG¹, Qi CHEN³, authorsList=Yan-rong FENG, Xiao-yu LIU, Tian HAO, Rui DONG, Cen-yu WANG, Jing-hong ZHANG, Qi CHEN, authorCompany=null, correspAuthors=Xiao-yu LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404698330849682, articleId=1291404697626206608, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=PCSK9抑制药的临床研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

低密度脂蛋白胆固醇（LDL-C）是动脉粥样硬化性心血管疾病（ASCVD）的致病性危险因素，因此国内外指南均建议严格管理其水平。他汀类药物是降脂治疗的基石，部分患者用中等剂量的他汀类药物仍不能使LDL-C达标，而且他汀类药物存在6%效应，因此需要联合新型降脂药物。前蛋白转化酶枯草菌素9（PCSK9）抑制药是目前的新型降脂药物，通过降低体内PCSK9的水平或抑制其功能，进一步降低血浆内LDL-C水平，从而发挥调节血脂、逆转动脉粥样硬化斑块等作用。我国目前临床应用的PCSK9抑制药有依洛尤单克隆抗体、阿利西尤单克隆抗体、英克司兰等。本文简述PCSK9抑制药药物分类及相关临床研究，概括PCSK9抑制药在调节血脂、影响动脉粥样硬化斑块等方面的研究现状。

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冯艳荣（1997-），女，医师，主要从事心血管疾病及降脂药物的相关研究

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冯艳荣（1997-），女，医师，主要从事心血管疾病及降脂药物的相关研究

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