Article(id=1291404870678991447, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404681641713991, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.07.022, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1728748800000, receivedDateStr=2024-10-13, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824514311, onlineDateStr=2026-08-04, pubDate=1744819200000, pubDateStr=2025-04-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824514311, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824514311, creator=13701087609, updateTime=1785824514311, updator=13701087609, issue=Issue{id=1291404681641713991, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='7', pageStart='901', pageEnd='1050', issueExtLink='null', onlineDate='null', pubDate='1744819200000', pubDateStr='2025-04-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824469242, creator='13701087609', updateTime=1785824469242, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=1020, endPage=1025, ext={EN=ArticleExt(id=1291404870976787032, articleId=1291404870678991447, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of ncRNA-Nrf2-NF-κB signaling pathway and anti-atherosclerotic drugs for regulating blood lipids, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Non-coding RNA (ncRNA), nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor κB (NF-κB) signaling pathways are involved in the interaction between ncRNA, Nrf2 and NF-κB, the mechanism that regulates blood lipids and anti-atherosclerosis. ncRNA, including microRNA (miRNA), small interfering RNA (siRNA), long non-coding RNA (lncRNA) and circular RNA (circRNA), are potential drug targets in the study of lipid regulation and anti-atherosclerosis drugs. Nrf2-NF-κB signaling pathway is an important pathway for regulating oxidative stress and inflammatory responses, regulating lipid levels and reducing the risk of cardiovascular diseases such as atherosclerosis. In addition, ncRNA, as an important regulatory molecule, can regulate oxidative stress and inflammation by regulating Nrf2-NF-κB signaling pathway, thus play an important role in regulating blood lipids and anti-atherosclerosis. This paper reviews the current research and development status of ncRNA-Nrf2-NF-κB signaling pathway in the field of lipid-regulating anti-atherosclerotic drugs, including drugs currently on the market and drugs under development, in order to provide new ideas and directions for the prevention and treatment of cardiovascular diseases such as atherosclerosis.

, authors=An HUANG^{1a, 1b, 1c}, Xiao-dan MO^{1a, 1b, 1c}, Xiu-fen YANG^{1a, 1b, 1c}, authorsList=An HUANG, Xiao-dan MO, Xiu-fen YANG, authorCompany=null, correspAuthors=Xiu-fen YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404873489175129, articleId=1291404870678991447, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=ncRNA-Nrf2-NF-κB信号通路与调血脂抗动脉粥样硬化药物的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

非编码RNA（ncRNA）、核因子E2相关因子2（Nrf2）和核因子κB（NF-κB）信号通路涉及ncRNA、Nrf2和NF-κB之间的相互作用，该调控机制可以调节血脂和抗动脉粥样硬化。ncRNA包括微小RNA（miRNA）、小干扰RNA（siRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA），是调血脂抗动脉粥样硬化药物研究中潜在的药物靶点。Nrf2-NF-κB信号通路是调节氧化应激和炎症反应的重要途径，可以调节血脂水平并降低动脉粥样硬化等心血管疾病的风险。此外，ncRNA作为一种重要的调控分子，可以通过调控Nrf2-NF-κB信号通路调节氧化应激和炎症反应，从而起到调血脂抗动脉粥样硬化的作用。本文综述ncRNA-Nrf2-NF-κB信号通路在调血脂抗动脉粥样硬化药物领域的研究与开发现状，包括目前已上市的药物和正在研发中的药物，以期为动脉粥样硬化等心血管疾病的预防和治疗提供新的思路和方向。

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黄安（2000-），女，硕士研究生，主要从事心脑血管药理学的相关研究

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黄安（2000-），女，硕士研究生，主要从事心脑血管药理学的相关研究

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