Article(id=1291404725350556228, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404681641713991, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.07.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729440000000, receivedDateStr=2024-10-21, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824479663, onlineDateStr=2026-08-04, pubDate=1744819200000, pubDateStr=2025-04-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824479663, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824479663, creator=13701087609, updateTime=1785824479663, updator=13701087609, issue=Issue{id=1291404681641713991, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='7', pageStart='901', pageEnd='1050', issueExtLink='null', onlineDate='null', pubDate='1744819200000', pubDateStr='2025-04-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824469242, creator='13701087609', updateTime=1785824469242, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=962, endPage=966, ext={EN=ArticleExt(id=1291404725610603077, articleId=1291404725350556228, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Comparative study of Yupingfeng powder on lipopolysaccharide induced lung injury in mice on macrophage pyroptosis, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the effects of different dosage forms of Yupingfeng powder on lipopolysaccharide induced pyroptosis of mouse lung macrophages.
Methods The RAW264.7 cells were randomly divided into normal, model, decoction piece and granule groups. Except for normal group, the other 3 groups were used lipopolysaccharide concentration to conduct a cellular inflammation model. No drug will be given to the normal group, and normal cultivation; the model group was treated with lipopolysaccharide; the decoction piece group was treated with lipopolysaccharide and decoction piece containing serum; the granule group was treated with lipopolysaccharide and granule containing serum. The macrophage inflammatory factor was detected by enzyme-linked immunosorbent assay. The expression levels of cell pyroptosis pathway protein were detected by Western blot.
Results The tumor necrosis factor -α (TNF-α) contents in cell supernatant of normal, model, decoction piece and granule groups were (48.19±12.00), (154.48±34.84), (125.80±29.66) and (125.73±28.88) pg·mL-1; the interleukin (IL) -18 levels were (21.36±4.36), (78.33±14.41), (49.77±9.50) and (49.27±9.40) pg·mL-1; the Caspase-1 levels were (39.72±10.58), (149.49±20.92), (93.25±16.73) and (91.93±16.45) pg·mL-1; the IL-1β levels were (17.14±3.41), (74.43±16.04), (45.01±9.40) and (43.34±8.96) pg·mL-1; the relative expression levels of TNF-α mRNA were 1.00±0.05, 2.17±0.07, 1.50±0.20 and 1.35±0.08; the relative expression levels of nuclear factor kappa-B mRNA were 1.00±0.01, 2.02±0.01, 1.52±0.01 and 1.50±0.03; the relative expression levels of IL-18 mRNA were 1.00±0.03, 1.48±0.04, 1.18±0.04 and 1.13±0.10; the relative expression levels of Caspase-1 mRNA were 1.00±0.04, 1.90±0.03, 1.59±0.04 and 1.49±0.10; the relative expression levels of IL-1β mRNA were 1.00±0.10, 1.74±0.08, 1.26±0.06 and 1.23±0.13, respectively. Compared with the model group, there were statistically significant differences of the above indicators in the granule group and the decoction piece group (P<0.05, P<0.01), but there were no statistically significant differences in the above indicators between the decoction piece group and the granule group (all P>0.05).
Conclusion Both formulations of Yupingfeng powder can reduce the expression level of proteins on the cell pyroptosis pathway and inhibit inflammatory response.
, authors=Ying-ying HE
1a, Li-na WANG
2, De-xing SUN
2, Zhi-cai JIA
1b, Qian LI
2, authorsList=Ying-ying HE, Li-na WANG, De-xing SUN, Zhi-cai JIA, Qian LI, authorCompany=null, correspAuthors=Qian LI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404726118113862, articleId=1291404725350556228, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=玉屏风散对脂多糖诱导的小鼠肺巨噬细胞焦亡的对比研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察不同剂型玉屏风散对脂多糖诱导的小鼠肺巨噬细胞焦亡的影响。
方法 将RAW264.7巨噬细胞随机分为正常组、模型组、饮片组和颗粒组。除正常组外，其余3组用脂多糖构建细胞炎症模型。正常组不给予任何药物，正常培养；模型组给予10 μg·mL-1脂多糖处置；饮片组给予10 μg·mL-1脂多糖+饮片含药血清处置；颗粒组给予10 μg·mL-1脂多糖+颗粒含药血清处置。用酶联免疫吸附试验法检测炎症因子的含量，用实时荧光定量聚合酶链反应法检测细胞焦亡通路mRNA的表达水平。
结果 正常组、模型组、饮片组和颗粒组细胞上清液中肿瘤坏死因子-α（TNF-α）含量分别为（48.19±12.00）、（154.48±34.84）、（125.80±29.66）和（125.73±28.88）pg·mL-1，白细胞介素（IL）-18含量分别为（21.36±4.36）、（78.33±14.41）、（49.77±9.50）和（49.27±9.40）pg·mL-1，胱天蛋白酶-1（Caspase-1）含量分别为（39.72±10.58）、（149.49±20.92）、（93.25±16.73）和（91.93±16.45）pg·mL-1，IL-1β含量分别为（17.14±3.41）、（74.43±16.04）、（45.01±9.40）和（43.34±8.96）pg·mL-1，TNF-α mRNA相对表达水平分别为1.00±0.05、2.17±0.07、1.50±0.20和1.35±0.08，核因子κB mRNA相对表达水平分别为1.00±0.01、2.02±0.01、1.52±0.01和1.50±0.03，IL-18 mRNA相对表达水平分别为1.00±0.03、1.48±0.04、1.18±0.04和1.13±0.10，Caspase-1 mRNA相对表达水平分别为1.00±0.04、1.90±0.03、1.59±0.04和1.49±0.10，IL-1β mRNA相对表达水平分别为1.00±0.10、1.74±0.08、1.26±0.06和1.23±0.13。颗粒组和饮片组的上述指标与模型组比较，在统计学上差异均有统计学意义（P<0.05，P<0.01）；饮片组和颗粒组的上述指标比较，在统计学上差异均无统计学意义（均P>0.05）。
结论 玉屏风散2种剂型均能够降低细胞焦亡通路上蛋白的表达水平，抑制炎症反应。
, authors=何莹莹
1a, 王丽娜
2, 孙德兴
2, 贾志财
1b, 李倩
2, authorsList=何莹莹, 王丽娜, 孙德兴, 贾志财, 李倩, authorCompany=null, correspAuthors=李倩, authorNote=
何莹莹（2000-），女，硕士研究生，主要从事职业病防治的相关研究
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