Article(id=1291404677413851797, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.06.023, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1728489600000, receivedDateStr=2024-10-10, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824468233, onlineDateStr=2026-08-04, pubDate=1743091200000, pubDateStr=2025-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824468233, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824468233, creator=13701087609, updateTime=1785824468233, updator=13701087609, issue=Issue{id=1291404554201985968, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1743091200000', pubDateStr='2025-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824438858, creator='13701087609', updateTime=1785897146949, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291709514101846462, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291709514101846463, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=872, endPage=876, ext={EN=ArticleExt(id=1291404677640344214, articleId=1291404677413851797, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Rapid health technology assessment of trastuzumab emtansine for the treatment of HER2-positive metastatic breast cancer, columnId=1246531412438966969, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Reader’s Field, runingTitle=null, highlight=null, articleAbstract=
Objective To evaluate the efficacy, safety, and economy of trastuzumab emtansine (T-DM1) in the treatment of human epidermal growth factor receptor 2(HER2)-positive metastatic breast cancer based on the rapid health technology assessment methodology, and to provide a reference for the rational use of the drug in the clinic.
Methods A systematic search of Chinese and English databases such as PubMed, Embase, the Cochrane Library, CNKI, Wanfang, SinoMed, etc. was performed to screen the literature according to the inclusion and exclusion criteria, extract the data, evaluate the quality of the literature, and qualitatively analyze the results.
Results T-DM1 had comparable or even superior efficacy in terms of progression-free survival (PFS) and overall survival (OS) compared with conventional anti-HER2 treatment regimens as well as other chemotherapeutic regimens. Some regimens, such as docetaxel+trastuzumab+patuximab, and pyrrolitinib+capecitabine, might be superior to T-DM1 in terms of PFS and OS. Adverse effects of T-DM1 were mainly liver function abnormalities and thrombocytopenia, and overall the safety profile was better, with a lower probability of serious adverse effects. In terms of economy, T-DM1 was more favorable than T-Dxd, and further evaluation was still needed compared with other regimens.
Conclusion T-DM1 has favorable efficacy and safety, with economics to be further evaluated.
, authors=Zhi-qi ZHANG, Zhuo ZHANG, Qian-xin LIU, Xiao-cong PANG, Ying ZHOU, authorsList=Zhi-qi ZHANG, Zhuo ZHANG, Qian-xin LIU, Xiao-cong PANG, Ying ZHOU, authorCompany=null, correspAuthors=Ying ZHOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404679515198103, articleId=1291404677413851797, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=恩美曲妥珠单抗治疗HER2阳性转移性乳腺癌的快速卫生技术评估, columnId=1246531414020219657, journalTitle=中国临床药理学杂志, columnName=读者园地, runingTitle=null, highlight=null, articleAbstract=
目的 基于快速卫生技术评估方法，评价恩美曲妥珠单抗（T-DM1）治疗人表皮生长因子受体2（HER2）阳性转移性乳腺癌的有效性、安全性与经济性，为临床合理用药提供参考。
方法 系统检索PubMed、Embase、the Cochrane Library、CNKI、万方、SinoMed等中英文数据库，根据入选和排除标准筛选文献，提取数据，评价文献质量，对结果进行定性分析。
结果 T-DM1在无进展生存期（PFS）与总生存期（OS）方面与传统的抗HER2治疗方案以及其他化疗方案相比，疗效相当甚至更优。部分治疗方案如多西他赛+曲妥珠单抗+帕妥珠单抗、吡咯替尼+卡培他滨，在PFS与OS方面可能较T-DM1更优。T-DM1的药物不良反应主要为肝功能异常与血小板减少，总体而言安全性较好，发生严重药物不良反应的概率较低。在经济性方面，T-DM1较T-Dxd更有优势，与其他方案相比仍有待进一步评估。
结论 T-DM1具有良好的有效性与安全性，经济性有待进一步评估。
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张志琪（1997-），女，药师，主要从事抗肿瘤临床药学工作
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