Article(id=1291404595931115746, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.06.021, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729699200000, receivedDateStr=2024-10-24, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824448806, onlineDateStr=2026-08-04, pubDate=1743091200000, pubDateStr=2025-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824448806, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824448806, creator=13701087609, updateTime=1785824448806, updator=13701087609, issue=Issue{id=1291404554201985968, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1743091200000', pubDateStr='2025-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824438858, creator='13701087609', updateTime=1785824438858, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=862, endPage=865, ext={EN=ArticleExt(id=1291404596161802467, articleId=1291404595931115746, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Determination of furmonertinib in non-small cell lung cancer patients plasma by LC-MS/MS, columnId=1246531413395263850, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Research Method, runingTitle=null, highlight=null, articleAbstract=
Objective To devolope a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of furmonertinib in human plsama and apply this method to analyze the blood concentration of non-small cell lung cancer (NSCLC) patients after taking medicine.
Methods Furmonertinib -d3 was employed as the internal standard. The analyte and internal standard were extracted from plasma by protein precipitation with acetonitrile and chromatographed on Agilent Poroshell 120 SB-C18(2.1 mm×100.0 mm, 3.5 μm); mobile phase consisted of acetonitrile-10 mmoL-1 ammonium acetate(both of containing 0.1% formic acid); the whole analytical time was 3 min. The quantitative analysis were ionized with an electrospray ionization (ESI) source and operated in positive ion, multiple reaction monitoring (MRM) mode, the specificity, linear range, precision and accuracy, extraction recovery rate, matrix effect, dilution validation, and stability were all investigated.
Results The standard curves were demonstrated to be liner in the range of 0.50-100.00 μg·L-1 with y=3.95×10-2x-4.16×10-4 (r=0.995 4). The accuracy was 95.8%-107.3%. The coefficient of variation (CV) of inter-day (n=6) and intra-day (n=3) for four different concentration levels were less than 15%. The average recoveries and matrix effects were between 83.1%-88.2% and 94.6%-105.8%.
Conclusion The established LC-MS/MS method for determining the concentration of vormetinib meets the requirements of biological sample analysis and can be used for the concentration determination of vormetinib in clinical practice.
, authors=Min-yu CHENG
1, 2, Li LI
2, Qi SHEN
2, Hong-yu YANG
3, authorsList=Min-yu CHENG, Li LI, Qi SHEN, Hong-yu YANG, authorCompany=null, correspAuthors=Hong-yu YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404596421849316, articleId=1291404595931115746, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=用LC-MS/MS法测定非小细胞肺癌患者血浆中伏美替尼浓度, columnId=1246531413600784769, journalTitle=中国临床药理学杂志, columnName=研究方法, runingTitle=null, highlight=null, articleAbstract=
目的 建立液相色谱-串联质谱（LC-MS/MS）法测定人血浆中伏美替尼浓度，并将此方法应用于非小细胞肺癌患者服药后的血药浓度测定。
方法 伏美替尼-d3为内标，血浆样品用乙腈沉淀蛋白，色谱柱为Agilent Poroshell 120 SB-C18（2.1 mm×100.0 mm，3.5 μm），流动相A为10 mmoL-1醋酸铵溶液，流动相B为乙腈，梯度洗脱，进样时间为3 min。用电喷雾离子源，正离子模式，多反应监测（MRM）扫描方式进行检测。考察该方法的专属性、线性范围、精密度与准确度、提取回收率、基质效应和稳定性。
结果 伏美替尼在0.50~100.00 μg·L-1标准曲线为y=3.95×10-2x-4.16×10-4（r=0.995 4），准确度在95.8%~107.3%；批内（n=6）和批间（n=3）精密度良好，变异系数（CV）均小于15%；伏美替尼和内标的提取回收率在83.1%~88.2%，基质效应在94.6%~105.8%。
结论 建立的LC-MS/MS方法测定伏美替尼浓度符合生物样本分析要求，可用于临床伏美替尼的浓度测定。
, authors=程敏毓
1, 2, 李力
2, 沈琦
2, 羊红玉
3, authorsList=程敏毓, 李力, 沈琦, 羊红玉, authorCompany=null, correspAuthors=羊红玉, authorNote=
程敏毓（1974－），女，副主任药师，主要从事医院药学方面的工作
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