Article(id=1291404574208815158, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.06.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1730044800000, receivedDateStr=2024-10-28, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824443628, onlineDateStr=2026-08-04, pubDate=1743091200000, pubDateStr=2025-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824443628, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824443628, creator=13701087609, updateTime=1785824443628, updator=13701087609, issue=Issue{id=1291404554201985968, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1743091200000', pubDateStr='2025-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824438858, creator='13701087609', updateTime=1785824438858, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=811, endPage=815, ext={EN=ArticleExt(id=1291404574414336055, articleId=1291404574208815158, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of sodium aescinate on the differentiation of human umbilical cord mesenchymal stem cells into neural-like cells, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effects of sodium aescinate on the differentiation of human umbilical cord mesenchymal stem cells (HUMSC) into neural-like cells and its possible mechanism.
Methods HUMSC cells were randomly divided into blank group, experiment-L group, experiment-M group and experiment-H group. All the cells were cultured with neurobasal medium (NM) medium, cells in experiment-L group, experiment-M group and experiment-H group were treated with 1.00, 2.00 and 4.00 mg·L-1 sodium aescinate, respectively. The expression levels of neuron-like cells markers and synaptic markers were detected by reverse transcription-polymerase quantitative chain reaction (RT-qPCR) and Western blot.
Results The relative mRNA expression levels of microtubule-associated protein 2 (MAP-2) in blank group, experiment-L group, experiment-M group and experiment-H group were 1.00±0.14, 1.26±0.08, 1.74±0.16 and 2.30±0.20, respectively; the relative mRNA expression levels of growth associated protein 43(GAP43) were 1.00±0.10, 1.14±0.15, 1.34±0.15 and 1.53±0.11, respectively; the relative expression levels of synaptophysin(SYN) mRNA were 1.00±0.09, 1.15±0.08, 1.32±0.12 and 1.48±0.13, respectively; the expression levels of neurofilament heavy chain(NF-H) protein were 0.41±0.04, 0.50±0.06, 0.71±0.06 and 1.21±0.09, respectively; postsynaptic density protein 95(PSD95) protein expression levels were 0.27±0.04, 0.41±0.06, 0.52±0.04 and 0.68±0.06, respectively; silent information regulator 1(SIRT1) protein expression levels were 0.31±0.04, 0.52±0.06, 0.67±0.06 and 0.80±0.10, respectively. The above indexes in experiment-L group, experiment-M group and experiment-H group were compared with blank group, the differences were all statistical significant (P<0.05, P<0.01); the above indexes compared among experiment-L group, experiment-M group and experiment-H group, the differences were all statistically significant (P<0.05, P<0.01).
Conclusion Sodium aescinate may induce the differentiation of HUMSC into neural-like cells by regulating SIRT1 in vitro.
, authors=Xiao-ran PAN, Yong ZHU, Jian ZHOU, Guang-hong XIANG, authorsList=Xiao-ran PAN, Yong ZHU, Jian ZHOU, Guang-hong XIANG, authorCompany=null, correspAuthors=Guang-hong XIANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404574800212024, articleId=1291404574208815158, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=七叶皂苷钠对人脐带间充质干细胞向神经样细胞分化的诱导作用, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 研究七叶皂苷钠对人脐带源性间充质干细胞（HUMSC）向神经样细胞分化的诱导作用及其可能的机制。
方法 将HUMSC细胞随机分为空白组、低剂量实验组、中剂量实验组、高剂量实验组。所有组细胞均用Neurobasal Medium（NM）培养基培养，低、中、高剂量实验组细胞分别用1.00、2.00、4.00 mg·L-1七叶皂苷钠处理细胞。用实时荧光定量逆转录聚合酶链反应（RT-qPCR）实验和蛋白质印迹实验检测神经样细胞标志物及神经元突触标志物的表达水平。
结果 空白组和低、中、高剂量实验组的微管相关蛋白-2（MAP-2）mRNA相对表达水平分别为1.00±0.14、1.26±0.08、1.74±0.16和2.30±0.20，生长相关蛋白43（GAP43）mRNA相对表达水平分别为1.00±0.10、1.14±0.15、1.34±0.15和1.53±0.11，突触素（SYN）mRNA相对表达水平分别为1.00±0.09、1.15±0.08、1.32±0.12和1.48±0.13，神经丝重链（NF-H）蛋白相对表达水平分别为0.41±0.04、0.50±0.06、0.71±0.06和1.21±0.09，突触后密度蛋白95（PSD95）蛋白相对表达水平分别为0.27±0.04、0.41±0.06、0.52±0.04和0.68±0.06，沉默信息调节因子1（SIRT1）蛋白相对表达水平分别为0.31±0.04、0.52±0.06、0.67±0.06和0.80±0.10；低、中、高剂量实验组的上述指标分别与空白组比较，在统计学上差异均有统计学意义（P<0.05，P<0.01）；低、中、高剂量实验的上述指标组间比较，在统计学上差异均有统计学意义（P<0.05，P<0.01）。
结论 七叶皂苷钠可能通过调控SIRT1体外诱导HUMSC向神经样细胞分化。
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潘晓冉（1992-），女，主治医师，主要从事痴呆方面的相关工作
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