Article(id=1291404569322450962, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.06.009, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1731859200000, receivedDateStr=2024-11-18, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824442462, onlineDateStr=2026-08-04, pubDate=1743091200000, pubDateStr=2025-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824442462, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824442462, creator=13701087609, updateTime=1785824442462, updator=13701087609, issue=Issue{id=1291404554201985968, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1743091200000', pubDateStr='2025-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824438858, creator='13701087609', updateTime=1785897146949, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291709514101846462, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291709514101846463, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=794, endPage=799, ext={EN=ArticleExt(id=1291404569704132627, articleId=1291404569322450962, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Aloe-emodin regulates p53 signal pathway to inhibit epithelial mesenchymal transformation in pathological scar fibroblasts, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the effects of aloe-emodin on the proliferation, apoptosis, and epithelial-mesenchymal transition (EMT) of pathological scar fibroblasts, as well as its regulatory mechanisms.
Methods Proliferative scar fibroblasts (HSFb) were randomly divided into the following groups: HSFb control group (normal culture), HSFb low-dose group (25.00 μg·mL-1 aloe-emodin), HSFb medium-dose group (50.00 μg·mL-1 aloe-emodin), HSFb high-dose group (100.00 μg·mL-1 aloe-emodin), and HSFb-PFT-α group (100.00 μg·mL-1 aloe-emodin + 20.00 μmol·L-1 p53-specific inhibitor PFT-α). Keloid fibroblast (KFb) cells were randomly divided into the following groups: KFb control group (normal culture), KFb low-dose group (25.00 μg·mL-1 aloe-emodin), KFb medium-dose group (50.00 μg·mL-1 aloe-emodin), KFb high-dose group (100.00 μg·mL-1 aloe-emodin), and KFb-PFT-α group (100.00 μg·mL-1 aloe-emodin + 20.00 μmol·L-1 p53-specific inhibitor PFT-α). Cell viability was assessed using the cell counting kit-8 (CCK-8) assay, Western blotting was performed to detect the expression of p53 and EMT-related proteins, apoptosis was measured using the TUNEL assay.
Results The cell survival rates of the KFb control group, KFb low-dose group, KFb medium-dose group, and KFb high-dose group were (100.00±5.17)%, (84.13±8.34)%, (73.81±7.62)% and (54.59±3.47)%, respectively; the cell survival rates of the HSFb control group, HSFb low-dose group, HSFb medium-dose group, and HSFb high-dose group were (100.00±6.77)%, (83.50±6.08)%, (71.43±2.70)% and (61.80±4.79)%, respectively. The relative expression levels of p53 protein in the KFb control group, KFb low-dose group, KFb high-dose group, and KFb-PFT-α group were 0.31±0.04, 0.52±0.04, 0.76±0.06 and 0.38±0.05, respectively; the relative expression levels of E-cadherin protein were 0.35±0.04, 0.58±0.08, 0.76±0.13 and 0.41±0.06, respectively; the apoptosis rates were (4.82±0.59)%, (11.72±1.68)%, (20.36±1.93)% and (12.46±1.28)%, respectively; the relative expression levels of p53 protein in the HSFb control group, HSFb low-dose group, HSFb high-dose group, and HSFb-PFT-α group were 0.37±0.03, 0.48±0.05, 0.65±0.07 and 0.46±0.04, respectively; the relative expression levels of E-cadherin protein were 0.26±0.03, 0.46±0.05, 0.63±0.08 and 0.34±0.05, respectively; the apoptosis rates were (4.89±0.28)%, (13.98±0.83)%, (21.51±1.08)% and (12.95±1.10)%, respectively. The differences between the KFb low- and high-dose groups and the KFb control group, the KFb-PFT-α group and the KFb high-dose group, the HSFb low- and high-dose groups and the HSFb control group, and the HSFb-PFT-α group and the HSFb high-dose group were statistically significant (P<0.05, P<0.01, P<0.001).
Conclusion Aloe-emodin may inhibit the proliferation of pathological fibroblasts, EMT, and induce apoptosis by regulating the p53-related signaling pathway.
, authors=Yi-bin YANG, Zong-yong HUANG, Yi-bin HUANG, Ai-ben HUANG, authorsList=Yi-bin YANG, Zong-yong HUANG, Yi-bin HUANG, Ai-ben HUANG, authorCompany=null, correspAuthors=Yi-bin YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404570064842772, articleId=1291404569322450962, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=芦荟大黄素调控p53信号通路抑制病理性瘢痕成纤维细胞的上皮间质转化的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究芦荟大黄素对病理性瘢痕成纤维细胞增殖、凋亡及上皮间质转化（EMT）的影响及调控机制。
方法 将增生性瘢痕成纤维细胞（HSFb）随机分为HSFb对照组（正常培养）、HSFb低剂量组（25.00 μg·mL-1芦荟大黄素）、HSFb中剂量组（50.00 μg·mL-1芦荟大黄素）、HSFb高剂量组（100.00 μg·mL-1芦荟大黄素）、HSFb-PFT-α组（100.00 μg·mL-1芦荟大黄素+20.00 μmol·L-1 p53特异性抑制药PFT-α）。将人原代瘢痕疙瘩成纤维细胞（KFb）随机分为KFb对照组（正常培养）、KFb低剂量组（25.00 μg·mL-1芦荟大黄素）、KFb中剂量组（50.00 μg·mL-1芦荟大黄素）、KFb高剂量组（100.00 μg·mL-1芦荟大黄素）、KFb-PFT-α组（100.00 μg·mL-1芦荟大黄素+20.00 μmol·L-1 p53特异性抑制药PFT-α）。用细胞计数试剂盒-8（CCK-8）实验检测细胞存活率，用蛋白质印迹法检测p53及EMT相关蛋白的表达，原位末端标记法（Tunel）实验检测细胞凋亡。
结果 KFb对照组、KFb低剂量组、KFb中剂量组、KFb高剂量组的细胞存活率分别为（100.00±5.17）%、（84.13±8.34）%、（73.81±7.62）%和（54.59±3.47）%；HSFb对照组、HSFb低剂量组、HSFb中剂量组、HSFb高剂量组的细胞存活率分别为（100.00±6.77）%、（83.50±6.08）%、（71.43±2.70）%和（61.80±4.79）%；KFb对照组、KFb低剂量组、KFb高剂量、KFb-PFT-α组的调节蛋白53（p53）蛋白相对表达水平分别为0.31±0.04、0.52±0.04、0.76±0.06和0.38±0.05，上皮细胞钙黏蛋白（E-cadherin）蛋白相对表达水平分别为0.35±0.04、0.58±0.08、0.76±0.13和0.41±0.06，凋亡率分别为（4.82±0.59）%、（11.72±1.68）%、（20.36±1.93）%和（12.46±1.28）%；HSFb对照组、HSFb低剂量组、HSFb高剂量组、HSFb-PFT-α组的p53蛋白相对表达水平分别为0.37±0.03、0.48±0.05、0.65±0.07和0.46±0.04，E-cadherin蛋白相对表达水平分别为0.26±0.03、0.46±0.05、0.63±0.08和0.34±0.05，凋亡率分别为（4.89±0.28）%、（13.98±0.83）%、（21.51±1.08）%和（12.95±1.10）%。KFb低、高剂量组的上述指标与KFb对照组比较，KFb-PFT-α组的上述指标与KFb高剂量组比较，HSFb低、高剂量组的上述指标与HSFb对照组比较，HSFb-PFT-α组的上述指标与HSFb高剂量组比较，在统计学上差异均有统计学意义（P<0.05，P<0.01，P<0.001）。
结论 芦荟大黄素可能通过调控p53相关信号抑制病理性成纤维细胞增殖、EMT并诱导凋亡。
, authors=杨毅斌, 黄宗涌, 黄燚彬, 黄爱本, authorsList=杨毅斌, 黄宗涌, 黄燚彬, 黄爱本, authorCompany=null, correspAuthors=杨毅斌, authorNote=
杨毅斌（1983-），男，主管技师，主要从事病理技术方面工作和研究
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=DV08FyJf8/0b3dKme3fpFQ==, magXml=CxWKJ1QhjjrLzBlmSrKL6w==, pdfUrl=null, pdf=TdCm2qG7ikO+eRlwp11IPQ==, pdfFileSize=1771075, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=nrux51IOBiNV8Gu7PJLhMQ==, mapNumber=null, fund=null)}, authors=[Author(id=1291404628470526285, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=yesblueant@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291404628541829455, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, authorId=1291404628470526285, language=EN, stringName=Yi-bin YANG, firstName=Yi-bin, middleName=null, lastName=YANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Pathology, Women and Children’s Hospital Affiliated to Xiamen University, Xiamen Maternal and Child Health Hospital, Xiamen 361003, Fujian Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404628822847824, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, authorId=1291404628470526285, language=CN, stringName=杨毅斌, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=厦门大学 附属妇女儿童医院、厦门市妇幼保健院 病理科，福建 厦门 361003, bio={"content":"
杨毅斌（1983-），男，主管技师，主要从事病理技术方面工作和研究
"}, bioImg=null, bioContent=
杨毅斌（1983-），男，主管技师，主要从事病理技术方面工作和研究
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404628097233225, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, xref=null, ext=[AuthorCompanyExt(id=1291404628399223114, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, companyId=1291404628097233225, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pathology, Women and Children’s Hospital Affiliated to Xiamen University, Xiamen Maternal and Child Health Hospital, Xiamen 361003, Fujian Province, China), AuthorCompanyExt(id=1291404628407611723, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, companyId=1291404628097233225, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=厦门大学 附属妇女儿童医院、厦门市妇幼保健院 病理科，福建 厦门 361003)])]), Author(id=1291404628885762386, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404629250666836, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, authorId=1291404628885762386, language=EN, stringName=Zong-yong HUANG, firstName=Zong-yong, middleName=null, lastName=HUANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Pathology, Women and Children’s Hospital Affiliated to Xiamen University, Xiamen Maternal and Child Health Hospital, Xiamen 361003, Fujian Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404629313581397, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, authorId=1291404628885762386, language=CN, stringName=黄宗涌, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=厦门大学 附属妇女儿童医院、厦门市妇幼保健院 病理科，福建 厦门 361003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404628097233225, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, xref=null, ext=[AuthorCompanyExt(id=1291404628399223114, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, companyId=1291404628097233225, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pathology, Women and Children’s Hospital Affiliated to Xiamen University, Xiamen Maternal and Child Health Hospital, Xiamen 361003, Fujian Province, China), AuthorCompanyExt(id=1291404628407611723, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, companyId=1291404628097233225, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=厦门大学 附属妇女儿童医院、厦门市妇幼保健院 病理科，福建 厦门 361003)])]), Author(id=1291404629384884567, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404629703651673, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, authorId=1291404629384884567, language=EN, stringName=Yi-bin HUANG, firstName=Yi-bin, middleName=null, lastName=HUANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Pathology, Women and Children’s Hospital Affiliated to Xiamen University, Xiamen Maternal and Child Health Hospital, Xiamen 361003, Fujian Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404630093721946, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, authorId=1291404629384884567, language=CN, stringName=黄燚彬, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=厦门大学 附属妇女儿童医院、厦门市妇幼保健院 病理科，福建 厦门 361003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404628097233225, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, xref=null, ext=[AuthorCompanyExt(id=1291404628399223114, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, companyId=1291404628097233225, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pathology, Women and Children’s Hospital Affiliated to Xiamen University, Xiamen Maternal and Child Health Hospital, Xiamen 361003, Fujian Province, China), AuthorCompanyExt(id=1291404628407611723, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, companyId=1291404628097233225, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=厦门大学 附属妇女儿童医院、厦门市妇幼保健院 病理科，福建 厦门 361003)])]), Author(id=1291404630190190940, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404630571872606, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, authorId=1291404630190190940, language=EN, stringName=Ai-ben HUANG, firstName=Ai-ben, middleName=null, lastName=HUANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Pathology, Women and Children’s Hospital Affiliated to Xiamen University, Xiamen Maternal and Child Health Hospital, Xiamen 361003, Fujian Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404630634787167, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, authorId=1291404630190190940, language=CN, stringName=黄爱本, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=厦门大学 附属妇女儿童医院、厦门市妇幼保健院 病理科，福建 厦门 361003, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404628097233225, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, xref=null, ext=[AuthorCompanyExt(id=1291404628399223114, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, companyId=1291404628097233225, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pathology, Women and Children’s Hospital Affiliated to Xiamen University, Xiamen Maternal and Child Health Hospital, Xiamen 361003, Fujian Province, China), AuthorCompanyExt(id=1291404628407611723, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, companyId=1291404628097233225, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=厦门大学 附属妇女儿童医院、厦门市妇幼保健院 病理科，福建 厦门 361003)])])], keywords=[Keyword(id=1291404631033246048, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, language=EN, orderNo=1, keyword=aloe-emodin), Keyword(id=1291404631389761889, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, language=EN, orderNo=2, keyword=pathological scar), Keyword(id=1291404631767249250, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, language=EN, orderNo=3, keyword=fibroblast), Keyword(id=1291404632174096739, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, language=EN, orderNo=4, keyword=epithelial mesenchymal transformation), Keyword(id=1291404632249594213, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, language=EN, orderNo=5, keyword=p53 signal pathway), Keyword(id=1291404632614498662, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, language=CN, orderNo=1, keyword=芦荟大黄素), Keyword(id=1291404632685801831, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, language=CN, orderNo=2, keyword=病理性瘢痕), Keyword(id=1291404633025540456, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, language=CN, orderNo=3, keyword=成纤维细胞), Keyword(id=1291404633088455017, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, language=CN, orderNo=4, keyword=上皮间质转化), Keyword(id=1291404633155563882, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, language=CN, orderNo=5, keyword=p53信号通路)], refs=null, funds=null, companyList=[AuthorCompany(id=1291404628097233225, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, xref=null, ext=[AuthorCompanyExt(id=1291404628399223114, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, companyId=1291404628097233225, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Pathology, Women and Children’s Hospital Affiliated to Xiamen University, Xiamen Maternal and Child Health Hospital, Xiamen 361003, Fujian Province, China), AuthorCompanyExt(id=1291404628407611723, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404569322450962, companyId=1291404628097233225, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=厦门大学 附属妇女儿童医院、厦门市妇幼保健院 病理科，福建 厦门 361003)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1784020014723, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1283836250926859016, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014745, updatedTime=1784020014745, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1283836250981384969, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014758, updatedTime=1784020014758, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.06.009, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.06.009, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.06.009, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.06.009, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1743091200000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
5
2
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
