Article(id=1291404554638193584, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404554201985968, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.06.002, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1730044800000, receivedDateStr=2024-10-28, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824438962, onlineDateStr=2026-08-04, pubDate=1743091200000, pubDateStr=2025-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824438962, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824438962, creator=13701087609, updateTime=1785824438962, updator=13701087609, issue=Issue{id=1291404554201985968, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='6', pageStart='751', pageEnd='900', issueExtLink='null', onlineDate='null', pubDate='1743091200000', pubDateStr='2025-03-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824438858, creator='13701087609', updateTime=1785824438858, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=755, endPage=760, ext={EN=ArticleExt(id=1291404554835325873, articleId=1291404554638193584, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of atorvastatin calcium combined with trimetazidine in the treatment of patients with chronic heart failure, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To observe the clinical efficacy and safety of different doses of atorvastatin calcium tablets combined with trimetazidine hydrochloride tablets in the treatment of patients with chronic heart failure (CHF).
Methods CHF patients were randomly assigned to low-dose group, high-dose group and control group using a digital randomization method. The control group received conventional heart failure treatment in addition to trimetazidine hydrochloride tablets (20 mg per dose, tid). The low-dose group received conventional atorvastatin calcium tablets (20 mg per dose, qd) on basis of the treatment given to the control group. The high-dose group received higher dose of atorvastatin calcium tablets (40 mg per dose, qd) in addition to the treatment for the control group. All treatment continued for 3 months. The clinical efficacy, heart function indicators, three-dimensional myocardial fibrosis parameters, myocardial cell apoptosis-related factors and safety were compared among the three groups.
Results A total of 8 cases were dropped during the trial, and 30 cases were included in the low-dose group, 24 cases in the high-dose group, and 26 cases in the control group. After treatment, the efficacy rates were 76.67% (23 cases/30 cases) for the low-dose group, 91.67% (22 cases/24 cases) for the high-dose group, and 61.54% (16 cases/26 cases) for the control group. The difference between the high-dose group and the control group was statistically significant (P<0.05). After treatment, the left ventricular ejection fractions for the low-dose group, high-dose group and control group were (52.25±2.11)%, (55.34±2.76)% and (48.72±2.48)%, respectively; the left ventricular end-diastolic diameters were (51.33±3.94), (48.63±4.79) and (55.79±4.85) mm, respectively; the left ventricular end-systolic diameters were (39.77±3.53), (36.72±3.29) and (42.78±3.69) mm, respectively; troponin Ⅰ levels were (1.62±0.33), (1.36±0.29) and (1.84±0.36) ng·L-1, respectively; N-terminal pro B-type natriuretic peptide levels were (797.25±79.32), (749.20±84.65) and (854.15±90.57) pg·mL-1, respectively; global strain values were -29.87±5.19, -32.96±5.82 and -26.33±5.46, respectively; cell membrane receptor protein levels were (2.55±0.46), (2.30±0.36) and (2.84±0.50) μg·L-1, respectively; soluble Fas ligand levels were (0.23±0.06), (0.19±0.04) and (0.28±0.09) μg·L-1, respectively; the differences among the three groups and between each pair of groups for the above indicators were statistically significant (P<0.05, P<0.01, P<0.001). The main adverse drug reactions in the low-dose group were gastrointestinal bloating and constipation, while the high-dose group primarily experienced constipation. The control group mainly reported nausea. The incidences of adverse drug reactions in the low-dose, high-dose and control groups were 6.67%, 4.17% and 3.85%, respectively, without statistically significant differences (all P>0.05).
Conclusion The curative effect of intensive dose atorvastain calcium tablets combined with trimetazidine hydrochloride tablets in the treatment of CHF is better than that of conventional dose atorvastatin combined with trimetazidine hydrochloride tablets, and the safety is good.
, authors=Min WANG, Zi-qiang ZHANG, Jun QIAN, authorsList=Min WANG, Zi-qiang ZHANG, Jun QIAN, authorCompany=null, correspAuthors=Jun QIAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404555170870194, articleId=1291404554638193584, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=阿托伐他汀钙联合曲美他嗪治疗慢性心力衰竭患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 观察不同剂量阿托伐他汀钙片联合盐酸曲美他嗪片治疗慢性心力衰竭（CHF）患者的临床疗效及安全性。
方法 将CHF患者根据数字随机法分成低剂量组、高剂量组和对照组。对照组在常规抗心力衰竭治疗基础上，予以盐酸曲美他嗪片，每次20 mg，tid；低剂量组在对照组治疗的基础上，予以常规剂量阿托伐他汀钙片，每次20 mg，qd；高剂量组在对照组治疗的基础上，予以强化剂量阿托伐他汀钙片，每次40 mg，qd，各组均持续治疗3个月。比较3组患者的临床疗效、心功能指标、三维心肌纤维化参数指标、心肌细胞凋亡相关因子水平及安全性。
结果 试验过程中共脱落8例，最终低剂量组纳入30例，高剂量组纳入24例，对照组纳入26例。治疗后，低剂量组、高剂量组、对照组的总有效率分别为76.67%（23例/30例）、91.67%（22例/24例）和61.54%（16例/26例），高剂量组和对照组比较，在统计学上差异有统计学意义（P<0.05）。治疗后，低剂量组、高剂量组、对照组的左心室射血分数分别为（52.25±2.11）%、（55.34±2.76）%和（48.72±2.48）%，左心室舒张末期内径分别为（51.33±3.94）、（48.63±4.79）和（55.79±4.85）mm，左心室收缩末期内径分别为（39.77±3.53）、（36.72±3.29）和（42.78±3.69）mm，肌钙蛋白Ⅰ分别为（1.62±0.33）、（1.36±0.29）和（1.84±0.36）ng·L-1，N末端B型脑钠肽前体分别为（797.25±79.32）、（749.20±84.65）和（854.15±90.57）pg·mL-1，整体应变分别为-29.87±5.19、-32.96±5.82和-26.33±5.46，细胞膜受体蛋白分别为（2.55±0.46）、（2.30±0.36）和（2.84±0.50）μg·L-1，可溶性Fas配体分别为（0.23±0.06）、（0.19±0.04）和（0.28±0.09）μg·L-1。低剂量组、高剂量组、对照组的上述指标组间两两比较，在统计学上差异均有统计学意义（P<0.05，P<0.01，P<0.001）。低剂量组药物不良反应主要有胃肠胀气、便秘，高剂量组药物不良反应主要有便秘，对照组药物不良反应主要有恶心。低剂量组、高剂量组和对照组的总药物不良反应发生率分别为6.67%、4.17%和3.85%，在统计学上差异均无统计学意义（均P>0.05）。
结论 强化剂量阿托伐他汀钙片联合盐酸曲美他嗪片治疗CHF患者的临床疗效较佳，明显优于常规剂量阿托伐他汀联合盐酸曲美他嗪疗法，并且安全性良好。
, authors=汪敏, 章梓强, 钱钧, authorsList=汪敏, 章梓强, 钱钧, authorCompany=null, correspAuthors=钱钧, authorNote=
汪敏（1981-），女，副主任医师，主要从事心脏起搏器和心力衰竭方向的临床诊疗方面的工作
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=ojpZw1TopQ0AOrx6XuB72w==, magXml=I6JKIrXLSnOqrmGCB/K4+w==, pdfUrl=null, pdf=tSFS3iCsNm0gEHwAupqIvw==, pdfFileSize=1374887, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=5oChfbBYIR8auYkIBCRDJA==, mapNumber=null, fund=null)}, authors=[Author(id=1291404693176046316, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404693368984302, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, authorId=1291404693176046316, language=EN, stringName=Min WANG, firstName=Min, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Cardiology, Deyu Medical Maanshan General Hospital, Maanshan 243000, Anhui Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404693452870383, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, authorId=1291404693176046316, language=CN, stringName=汪敏, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=德驭医疗马鞍山总医院 心血管内科，安徽 马鞍山 243000, bio={"content":"
汪敏（1981-），女，副主任医师，主要从事心脏起搏器和心力衰竭方向的临床诊疗方面的工作
"}, bioImg=null, bioContent=
汪敏（1981-），女，副主任医师，主要从事心脏起搏器和心力衰竭方向的临床诊疗方面的工作
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404693066994408, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, xref=null, ext=[AuthorCompanyExt(id=1291404693075383017, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, companyId=1291404693066994408, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Cardiology, Deyu Medical Maanshan General Hospital, Maanshan 243000, Anhui Province, China), AuthorCompanyExt(id=1291404693096354538, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, companyId=1291404693066994408, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=德驭医疗马鞍山总医院 心血管内科，安徽 马鞍山 243000)])]), Author(id=1291404693519979249, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291404693599671027, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, authorId=1291404693519979249, language=EN, stringName=Zi-qiang ZHANG, firstName=Zi-qiang, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Cardiology, Deyu Medical Maanshan General Hospital, Maanshan 243000, Anhui Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404693905855220, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, authorId=1291404693519979249, language=CN, stringName=章梓强, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=德驭医疗马鞍山总医院 心血管内科，安徽 马鞍山 243000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404693066994408, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, xref=null, ext=[AuthorCompanyExt(id=1291404693075383017, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, companyId=1291404693066994408, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Cardiology, Deyu Medical Maanshan General Hospital, Maanshan 243000, Anhui Province, China), AuthorCompanyExt(id=1291404693096354538, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, companyId=1291404693066994408, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=德驭医疗马鞍山总医院 心血管内科，安徽 马鞍山 243000)])]), Author(id=1291404694245593846, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=331507302@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291404694404977401, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, authorId=1291404694245593846, language=EN, stringName=Jun QIAN, firstName=Jun, middleName=null, lastName=QIAN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Cardiology, Deyu Medical Maanshan General Hospital, Maanshan 243000, Anhui Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291404694635664122, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, authorId=1291404694245593846, language=CN, stringName=钱钧, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=德驭医疗马鞍山总医院 心血管内科，安徽 马鞍山 243000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291404693066994408, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, xref=null, ext=[AuthorCompanyExt(id=1291404693075383017, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, companyId=1291404693066994408, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Cardiology, Deyu Medical Maanshan General Hospital, Maanshan 243000, Anhui Province, China), AuthorCompanyExt(id=1291404693096354538, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, companyId=1291404693066994408, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=德驭医疗马鞍山总医院 心血管内科，安徽 马鞍山 243000)])])], keywords=[Keyword(id=1291404694790853371, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, language=EN, orderNo=1, keyword=atorvastatin calcium tablet), Keyword(id=1291404694866350844, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, language=EN, orderNo=2, keyword=trimetazidine hydrochloride tablet), Keyword(id=1291404694954431229, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, language=EN, orderNo=3, keyword=chronic heart failure), Keyword(id=1291404695143174910, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, language=EN, orderNo=4, keyword=myocardial fibrosis), Keyword(id=1291404695214478079, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, language=EN, orderNo=5, keyword=myocardial cell apoptosis), Keyword(id=1291404695306752768, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, language=CN, orderNo=1, keyword=阿托伐他汀钙片), Keyword(id=1291404695382250241, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, language=CN, orderNo=2, keyword=盐酸曲美他嗪片), Keyword(id=1291404695487107842, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, language=CN, orderNo=3, keyword=慢性心力衰竭), Keyword(id=1291404695562605315, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, language=CN, orderNo=4, keyword=心肌纤维化), Keyword(id=1291404697294852868, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, language=CN, orderNo=5, keyword=心肌细胞凋亡)], refs=null, funds=null, companyList=[AuthorCompany(id=1291404693066994408, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, xref=null, ext=[AuthorCompanyExt(id=1291404693075383017, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, companyId=1291404693066994408, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Cardiology, Deyu Medical Maanshan General Hospital, Maanshan 243000, Anhui Province, China), AuthorCompanyExt(id=1291404693096354538, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404554638193584, companyId=1291404693066994408, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=德驭医疗马鞍山总医院 心血管内科，安徽 马鞍山 243000)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1784020014723, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1283836250926859016, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014745, updatedTime=1784020014745, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1283836250981384969, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014758, updatedTime=1784020014758, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.06.002, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.06.002, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.06.002, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.06.002, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1743091200000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
5
2
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
