Article(id=1291404466473914457, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404401374130524, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.05.027, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1727193600000, receivedDateStr=2024-09-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824417941, onlineDateStr=2026-08-04, pubDate=1742140800000, pubDateStr=2025-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824417941, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824417941, creator=13701087609, updateTime=1785824417941, updator=13701087609, issue=Issue{id=1291404401374130524, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1742140800000', pubDateStr='2025-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824402421, creator='13701087609', updateTime=1785824402421, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=737, endPage=741, ext={EN=ArticleExt(id=1291404466679435354, articleId=1291404466473914457, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of histological techniques in traditional Chinese medicine for prevention and treatment of endometriosis, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

The clinical efficacy of Chinese medicines in the prevention and treatment of endometriosis (EMs) is precise and can work through multiple pathways and targets. However, the complexity of the components of Chinese medicines and the single research method have led to slow progress in this field. With the emergence of high-throughput technologies, the limitations of single targets or pathways in interpreting the "holistic regulation" of TCM have been remedied by identifying genes associated with the pathophysiology of endometriosis. In this review, genomics, transcriptomics, proteomics, metabolomics, and their combinatorial techniques are reviewed to reveal the molecular mechanisms of Chinese herbal medicines in the prevention and treatment of endometriosis. It provides reference ideas for precise and objective revelation of prevention and treatment of EMs, as well as theoretical basis for revealing the mechanism of complex drug intervention in the disease.

, authors=Bin YUE1, Cui-jun CHU1, Wen-wen WAN1, Yuan-huan CHEN1, Can-can HUANG1, Yuan CHENG1, Xiao-hua ZHANG1, Quan-sheng WU1, Hai-yan MAO2, Li LIANG1, authorsList=Bin YUE, Cui-jun CHU, Wen-wen WAN, Yuan-huan CHEN, Can-can HUANG, Yuan CHENG, Xiao-hua ZHANG, Quan-sheng WU, Hai-yan MAO, Li LIANG, authorCompany=null, correspAuthors=Quan-sheng WU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404466968842331, articleId=1291404466473914457, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=组学技术在中药防治子宫内膜异位症中的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

中药防治子宫内膜异位症(EMs)的临床疗效确切,可以通过多途径、多靶点发挥作用。但中药成分的复杂性以及单一的研究方法导致该领域研究进展缓慢。随着高通量技术的出现,通过确定与EMs病理生理学相关的基因,弥补了单个靶点或通路诠释中药“整体调控”的局限性。本综述就基因组学、转录组学、蛋白组学、代谢组学及其联用组学技术揭示中药防治EMs的分子机制等相关研究进行综述,为精准化、客观化揭示防治EMs提供参考思路,同时也为揭示复杂药物干预疾病的机制提供理论依据。

, authors=岳斌1, 褚翠君1, 万文文1, 陈元欢1, 黄灿灿1, 程渊1, 张小花1, 武权生1, 毛海燕2, 梁莉1, authorsList=岳斌, 褚翠君, 万文文, 陈元欢, 黄灿灿, 程渊, 张小花, 武权生, 毛海燕, 梁莉, authorCompany=null, correspAuthors=武权生, authorNote=

岳斌(1993-),男,博士研究生,主要从事中医药对女性神经内分泌调控的相关研究

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武权生,主任医师,博士生导师 Tel: (0931)5161146 E-mail:
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岳斌(1993-),男,博士研究生,主要从事中医药对女性神经内分泌调控的相关研究

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岳斌(1993-),男,博士研究生,主要从事中医药对女性神经内分泌调控的相关研究

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组学技术在中药防治子宫内膜异位症中的研究现状
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岳斌 1 , 褚翠君 1 , 万文文 1 , 陈元欢 1 , 黄灿灿 1 , 程渊 1 , 张小花 1 , 武权生 1 , 毛海燕 2 , 梁莉 1
中国临床药理学杂志 | 综述 2025,41(5): 737-741
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中国临床药理学杂志 |综述 2025 , 41 (5) : 737 -741
组学技术在中药防治子宫内膜异位症中的研究现状
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岳斌(1993-),男,博士研究生,主要从事中医药对女性神经内分泌调控的相关研究

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兰州 730000)])])]
岳斌1, 褚翠君1, 万文文1, 陈元欢1, 黄灿灿1, 程渊1, 张小花1, 武权生1 , 毛海燕2, 梁莉1
作者信息
  • 1.甘肃中医药大学 中医临床学院,甘肃 兰州 730000
  • 2.甘肃省人民医院 中医科,甘肃 兰州 730000
通讯作者:
武权生,主任医师,博士生导师 Tel: (0931)5161146 E-mail:
作者简介:

岳斌(1993-),男,博士研究生,主要从事中医药对女性神经内分泌调控的相关研究

Research status of histological techniques in traditional Chinese medicine for prevention and treatment of endometriosis
Bin YUE1, Cui-jun CHU1, Wen-wen WAN1, Yuan-huan CHEN1, Can-can HUANG1, Yuan CHENG1, Xiao-hua ZHANG1, Quan-sheng WU1 , Hai-yan MAO2, Li LIANG1
Affiliations
  • 1.School of Clinical Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
  • 2.Department of Traditional Chinese Medicine, Gansu Provincial People’s Hospital, Lanzhou 730000, Gansu Province, China
出版时间: 2025-03-17 doi: 10.13699/j.cnki.1001-6821.2025.05.027
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中药防治子宫内膜异位症(EMs)的临床疗效确切,可以通过多途径、多靶点发挥作用。但中药成分的复杂性以及单一的研究方法导致该领域研究进展缓慢。随着高通量技术的出现,通过确定与EMs病理生理学相关的基因,弥补了单个靶点或通路诠释中药“整体调控”的局限性。本综述就基因组学、转录组学、蛋白组学、代谢组学及其联用组学技术揭示中药防治EMs的分子机制等相关研究进行综述,为精准化、客观化揭示防治EMs提供参考思路,同时也为揭示复杂药物干预疾病的机制提供理论依据。

中药  /  子宫内膜异位症  /  多组学技术  /  作用机制  /  研究现状

The clinical efficacy of Chinese medicines in the prevention and treatment of endometriosis (EMs) is precise and can work through multiple pathways and targets. However, the complexity of the components of Chinese medicines and the single research method have led to slow progress in this field. With the emergence of high-throughput technologies, the limitations of single targets or pathways in interpreting the "holistic regulation" of TCM have been remedied by identifying genes associated with the pathophysiology of endometriosis. In this review, genomics, transcriptomics, proteomics, metabolomics, and their combinatorial techniques are reviewed to reveal the molecular mechanisms of Chinese herbal medicines in the prevention and treatment of endometriosis. It provides reference ideas for precise and objective revelation of prevention and treatment of EMs, as well as theoretical basis for revealing the mechanism of complex drug intervention in the disease.

traditional Chinese medicine  /  endometriosis  /  multi-omics technology  /  mechanism of action  /  research status
岳斌, 褚翠君, 万文文, 陈元欢, 黄灿灿, 程渊, 张小花, 武权生, 毛海燕, 梁莉. 组学技术在中药防治子宫内膜异位症中的研究现状. 中国临床药理学杂志, 2025 , 41 (5) : 737 -741 . DOI: 10.13699/j.cnki.1001-6821.2025.05.027
Bin YUE, Cui-jun CHU, Wen-wen WAN, Yuan-huan CHEN, Can-can HUANG, Yuan CHENG, Xiao-hua ZHANG, Quan-sheng WU, Hai-yan MAO, Li LIANG. Research status of histological techniques in traditional Chinese medicine for prevention and treatment of endometriosis[J]. Chinese Journal of Clinical Pharmacology, 2025 , 41 (5) : 737 -741 . DOI: 10.13699/j.cnki.1001-6821.2025.05.027
  • 国家自然科学基金资助项目(81760879)
  • 国家自然科学基金地区科学基金资助项目(82260949)
  • 甘肃省自然科学基金资助项目(23JRRA1751; 23JRRA1757)
  • 甘肃省中医药科研课题资助项目(GZKP-2023-21)
  • 甘肃省人民医院院内科研基金资助项目(23GSSYE-1)
  • 甘肃省中医药研究中心开放课题资助项目(zyzx-2023-09)
  • 甘肃中医药大学人才引进基金资助项目(301/30140603)
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2025年第41卷第5期
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doi: 10.13699/j.cnki.1001-6821.2025.05.027
  • 接收时间:2024-09-25
  • 首发时间:2026-08-04
  • 出版时间:2025-03-17
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  • 收稿日期:2024-09-25
基金
国家自然科学基金资助项目(81760879)
国家自然科学基金地区科学基金资助项目(82260949)
甘肃省自然科学基金资助项目(23JRRA1751; 23JRRA1757)
甘肃省中医药科研课题资助项目(GZKP-2023-21)
甘肃省人民医院院内科研基金资助项目(23GSSYE-1)
甘肃省中医药研究中心开放课题资助项目(zyzx-2023-09)
甘肃中医药大学人才引进基金资助项目(301/30140603)
作者信息
    1.甘肃中医药大学 中医临床学院,甘肃 兰州 730000
    2.甘肃省人民医院 中医科,甘肃 兰州 730000

通讯作者:

武权生,主任医师,博士生导师 Tel: (0931)5161146 E-mail:
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2种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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