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急性肺损伤（ALI）/急性呼吸窘迫综合征是以肺血管通透性增加、炎性细胞浸润、肺水肿、弥漫性肺泡损伤和呼吸量减少为特征的危及生命的急性弥漫性肺部炎症损伤。ALI的发病机制复杂，而氧化应激是导致肺泡上皮细胞功能障碍，加剧ALI的关键机制。Kelch环氧氯丙烷相关蛋白1/核因子E2相关因子2（Keap1/Nrf2）信号通路是中医药通过调控氧化应激治疗ALI的重要信号通路。本文通过对治疗ALI的相关中药复方、活性成分进行分析、总结，发现大量抗氧化活性成分可以通过Keap1/Nrf2信号通路调控氧化应激，发挥改善ALI的作用，这也为ALI疾病的防治以及进一步的药物开发提供了依据。

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郝国雄（1996-），男，中医医师，主要从事急危重症方向的相关研究

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郝国雄（1996-），男，中医医师，主要从事急危重症方向的相关研究

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