Article(id=1291404407770440114, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404401374130524, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.05.017, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1729699200000, receivedDateStr=2024-10-24, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824403945, onlineDateStr=2026-08-04, pubDate=1742140800000, pubDateStr=2025-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824403945, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824403945, creator=13701087609, updateTime=1785824403945, updator=13701087609, issue=Issue{id=1291404401374130524, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1742140800000', pubDateStr='2025-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824402421, creator='13701087609', updateTime=1785824402421, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=686, endPage=690, ext={EN=ArticleExt(id=1291404408378614195, articleId=1291404407770440114, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Study on mechanism of cardioprotective effect of Ilexin A in improving hyperlipidemia, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the cardioprotective mechanism of Ilexin A in ameliorating hyperlipidemia through the regulation of microRNA-133a-3p (miR-133a-3p) and uncoupling protein 2 (UCP2).
Methods Rats were randomly divided into control group (gavage with an equal volume of distilled water as the experimental group), model group (gavage with an equal volume of distilled water as the experimental group), experimental group (gavage with 40 mg·kg-1 Ilexin A), miR-133a-3p inhibitor group (gavage with 40 mg·kg-1 Ilexin A + tail vein injection of 1.95×1012 vg·mL-1 adenovirus containing miR-133a-3p inhibitor), and OE-UCP2 group (gavage with 40 mg·kg-1 Ilexin A + tail vein injection of 1.95×1012 vg·mL-1 adenovirus containing both miR-133a-3p inhibitor and OE-UCP2). Blood lipid levels, including low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), were measured by enzyme-linked immunosorbent assay. Cardiac function parameters, such as the mitral inflow peak early diastolic velocity to late diastolic velocities (E/A) and left ventricular ejection fraction (LVEF), were assessed via echocardiography. The relative expression levels of mRNA were analyzed by real-time quantitative polymerase chain reaction (RT-qPCR), while protein levels were detected by Western blot.
Results In the model and experimental groups, LDL-C levels were (0.92±0.12) and (0.76±0.09) mmol·L-1; HDL-C levels were (0.82±0.10) and (1.14±0.13) mmol·L-1; E/A ratios were 0.89±0.11 and 1.17±0.14; LVEF values were (41.31±5.07)% and (59.92±7.86)%; the relative expression levels of miR-133a-3p were 0.33±0.06 and 1.22±0.18; uncoupling protein 2 (UCP2) mRNA levels were 0.57±0.08 and 0.79±0.09; cleaved caspase-3 protein levels were 1.00±0.15 and 0.71±0.09; B-cell lymphoma-2 (Bcl-2) protein levels were 1.00±0.17 and 1.94±0.27, respectively. The differences between the model and experimental groups for these parameters were statistically significant (all P<0.05).
Conclusion Ilexin A ameliorates hyperlipidemia by regulating miR-133a-3p and UCP2. Its mechanism may involve downregulating Bcl-2 and activating cleaved caspase-3 to induce apoptosis, thereby exerting cardioprotective effects and improving cardiac function.
, authors=Ying ZHANG
1, Li-hua SUN
2, Si-yan SHI
2, Wei-hao WANG
2, Hai-jun PENG
2, authorsList=Ying ZHANG, Li-hua SUN, Si-yan SHI, Wei-hao WANG, Hai-jun PENG, authorCompany=null, correspAuthors=Li-hua SUN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404408756101556, articleId=1291404407770440114, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=毛冬青皂苷A改善高脂血症发挥心脏保护作用的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨毛冬青皂苷A通过调节微小RNA-133a-3p（miR-133a-3p）及解偶联蛋白2（UCP2）改善高脂血症发挥心脏保护作用的机制。
方法 将大鼠随机分为对照组（灌胃与实验组等量蒸馏水）、模型组（灌胃与实验组等量蒸馏水）、实验组（灌胃40 mg·kg-1毛冬青皂苷A）、miR-133a-3p inhibitor组（灌胃40 mg·kg-1毛冬青皂苷A+尾静脉注射1.95×1012 vg·mL-1含有miR-133a-3p抑制剂的腺病毒）、OE-UCP2组（灌胃40 mg·kg-1毛冬青皂苷A+尾静脉注射1.95×1012 vg·mL-1含有miR-133a-3p抑制剂和含有OE-UCP2的腺病毒）。用酶联免疫吸附试验检测血脂水平指标[低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）等]，用心脏彩超测定心功能指标[舒张期早期血流速度E与晚期A的比值（E/A）、左心室射血分数（LVEF）等]，用实时荧光定量聚合酶链反应检测mRNA相对表达水平，用蛋白质印迹法检测蛋白相对表达水平。
结果 模型组和实验组的LDL-C水平分别为（0.92±0.12）和（0.76±0.09）mmol·L-1，HDL-C水平分别为（0.82±0.10）和（1.14±0.13）mmol·L-1，E/A分别为0.89±0.11和1.17±0.14，LVEF分别为（41.31±5.07）%和（59.92±7.86）%，miR-133a-3p相对表达水平分别为0.33±0.06和1.22±0.18，解偶联蛋白2（UCP2）mRNA相对水平分别为0.57±0.08和0.79±0.09，裂解的胱天蛋白酶3（Cleaved caspase-3）蛋白相对表达水平分别为1.00±0.15和0.71±0.09，B淋巴细胞瘤-2基因（Bcl-2）蛋白相对表达水平分别为1.00±0.17和1.94±0.27，模型组的上述指标与实验组比较，在统计学上差异有统计学意义（均P<0.05）。
结论 毛冬青皂苷A可通过调节miR-133a-3p及UCP2改善高脂血症，其机制可能与下调Bcl-2，激活Cleaved caspase-3诱导细胞凋亡相关，可发挥心脏保护作用，改善心功能。
, authors=张颖
1, 孙理华
2, 时司宴
2, 王维浩
2, 彭海军
2, authorsList=张颖, 孙理华, 时司宴, 王维浩, 彭海军, authorCompany=null, correspAuthors=孙理华, authorNote=
张颖（1977-），女，硕士，副主任医师，主要从事心血管方面的工作
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1.新疆医科大学 第五附属医院 心脏中心 高血压科，新疆维吾尔自治区 乌鲁木齐 830011)])]), Author(id=1291404411079745985, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404407770440114, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=sunlihua2024@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291404411188797891, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291404407770440114, authorId=1291404411079745985, language=EN, stringName=Li-hua SUN, firstName=Li-hua, middleName=null, lastName=SUN, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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