Article(id=1291404428985233889, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404401374130524, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.05.013, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1726761600000, receivedDateStr=2024-09-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824409003, onlineDateStr=2026-08-04, pubDate=1742140800000, pubDateStr=2025-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824409003, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824409003, creator=13701087609, updateTime=1785824409003, updator=13701087609, issue=Issue{id=1291404401374130524, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1742140800000', pubDateStr='2025-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824402421, creator='13701087609', updateTime=1785897165150, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1291709590438170760, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404401374130524, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1291709590438170761, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404401374130524, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=665, endPage=670, ext={EN=ArticleExt(id=1291404429266252258, articleId=1291404428985233889, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research of
circCSPP1 affects the growth and metastasis ability of gastric cancer cells by regulating autophagy, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effects of circCSPP1 mediated autophagy on the proliferation and metastasis ability of gastric cancer cells.
Methods The human gastric cancer cells NCI-N87 were divided into Vector group (transfected with Vector), circCSPP1 group (transfected with circCSPP1) and inhibitor group (transfected with circCSPP1 and incubated with 10 μmol·L-1 chloroquine). The MKN-45 cells were divided into sh-NC group (transfected with circCSPP1 shRNA-NC), sh-circCSPP1 group (transfected with circCSPP1 shRNA) and agonist group (transfected with circCSPP1 shRNA + 1 μmol·L-1 sirolimus). Flow cytometry was used to detect cell apoptosis. Transwell was used to detect cell migration and invasion. Western blot were used to detect the expression levels of microtubule associated protein light chain 3-Ⅱ (LC3-Ⅱ) and p62 protein.
Results In NCI-N87 cells: the apoptosis rates of Vector, circCSPP1 and inhibitor groups were (7.95±0.66)%, (3.93±0.62)% and (7.37±0.85)%; the number of cell migrations were 122.50±12.25, 169.40±16.09 and 109.00±8.22; the number of cell invasions were 73.38±12.33, 117.30±12.78 and 55.25±8.73; the relative expression levels of LC3-Ⅱ protein were 0.40±0.06, 1.13±0.11 and 0.44±0.08; the relative expression levels of p62 protein were 1.62±0.15, 0.21±0.08 and 1.43±0.16. The differences of above indexes were statistically significant between the circCSPP1 group and the inhibitor and Vector groups (all P<0.05). In MKN-45 cells: the cell apoptosis rates of sh-NC, sh-circCSPP1 and agonist groups were (6.81±0.68)%, (12.02±0.78)% and (5.76±1.21)%; the number of cell migrations were 191.60±21.43, 87.50±10.76 and 155.60±10.36; the number of cell invasions were 150.00±11.55, 61.63±11.39 and 154.50±17.99; the relative expression levels of LC3-Ⅱ protein were 1.08±0.05, 0.13±0.03 and 1.18±0.06; the relative expression levels of p62 protein were 0.15±0.03, 1.29±0.08 and 0.19±0.04. Compared with the sh-circCSPP1 group, the differences of above indicators in the agonist and sh-NC groups were statistically significant (all P<0.05).
Conclusion circCSPP1 can improve the proliferation and metastasis ability of gastric cancer cells by inducing autophagy.
, authors=Hou-feng FU, Bing LI, Zhen-xiong LIANG, Xing-lin WANG, authorsList=Hou-feng FU, Bing LI, Zhen-xiong LIANG, Xing-lin WANG, authorCompany=null, correspAuthors=Hou-feng FU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404429715042787, articleId=1291404428985233889, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=
circCSPP1调控自噬影响胃癌细胞生长和转移能力的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究circCSPP1介导的自噬对胃癌细胞增殖和转移能力的影响。
方法 将人胃癌细胞NCI-N87细胞分为Vector组（转染Vector）、circCSPP1组（转染circCSPP1）和抑制药组（转染circCSPP1后与10 μmol·L-1氯喹孵育）。将MKN-45细胞分为sh-NC组（转染circCSPP1 shRNA-NC）、sh-circCSPP1组（转染circCSPP1 shRNA）和激动药组（转染circCSPP1 shRNA后与1 μmol·L-1西罗莫司孵育）。用流式细胞术检测细胞的凋亡情况，用Transwell法检测细胞的迁移和侵袭情况，用蛋白质印迹法检测微管相关蛋白l轻链3-Ⅱ（LC3-Ⅱ）和p62蛋白的表达水平。
结果 在NCI-N87细胞中，Vector组、circCSPP1组和抑制药组的细胞凋亡率分别为（7.95±0.66）%、（3.93±0.62）%和（7.37±0.85）%，细胞迁移数分别为（122.50±12.25）、（169.40±16.09）和（109.00±8.22）个，细胞侵袭数分别为（73.38±12.33）、（117.30±12.78）和（55.25±8.73）个，LC3-Ⅱ蛋白相对表达水平分别为0.40±0.06、1.13±0.11和0.44±0.08，p62蛋白相对表达水平分别为1.62±0.15、0.21±0.08和1.43±0.16，抑制药组和Vector组的上述指标与circCSPP1组比较，在统计学上差异均有统计学意义（均P<0.05）。在MKN-45细胞中，sh-NC组、sh-circCSPP1组和激动药组的细胞凋亡率分别为（6.81±0.68）%、（12.02±0.78）%和（5.76±1.21）%，细胞迁移数分别为（191.60±21.43）、（87.50±10.76）和（155.60±10.36）个，细胞侵袭数分别为（150.00±11.55）、（61.63±11.39）和（154.50±17.99）个，LC3-Ⅱ蛋白相对表达水平分别为1.08±0.05、0.13±0.03和1.18±0.06，p62蛋白相对表达水平分别为0.15±0.03、1.29±0.08和0.19±0.04，激动药组和sh-NC组的上述指标与sh-circCSPP1组比较，在统计学上差异均有统计学意义（均P<0.05）。
结论 circCSPP1可以通过诱导自噬来提高胃癌细胞的增殖和转移能力。
, authors=傅厚丰, 李炳, 梁振雄, 王兴麟, authorsList=傅厚丰, 李炳, 梁振雄, 王兴麟, authorCompany=null, correspAuthors=傅厚丰, authorNote=
傅厚丰（1978-），男，副主任医师，主要从事非编码RNA和胃癌的相关研究
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