Article(id=1291404425000637351, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404401374130524, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.05.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1718380800000, receivedDateStr=2024-06-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824408054, onlineDateStr=2026-08-04, pubDate=1742140800000, pubDateStr=2025-03-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824408054, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824408054, creator=13701087609, updateTime=1785824408054, updator=13701087609, issue=Issue{id=1291404401374130524, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='5', pageStart='601', pageEnd='750', issueExtLink='null', onlineDate='null', pubDate='1742140800000', pubDateStr='2025-03-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824402421, creator='13701087609', updateTime=1785824402421, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=636, endPage=640, ext={EN=ArticleExt(id=1291404425210352552, articleId=1291404425000637351, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of cinacalcet in the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis for CKD, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the clinical effect of cinacalcet in the treatment of secondary hyperparathyroidism (SHPT) in patients undergoing hemodialysis for chronic kidney disease (CKD).
Methods Patients who underwent hemodialysis for CKD and had SHPT were divided into the control group and the treatment group according to the cohort method. The control group was treated with 0.25 μg of calcitriol capsules once a day via oral administration. On this basis, the treatment group was treated with 25 mg of cinacalcet tablets once a day via oral administration. Patients in both groups were treated for 12 weeks. Clinical efficacy, parathyroid volume, parathyroid function [serum phosphorus, serum calcium, alkaline phosphatase (ALP) and intact parathyroid hormone (iPTH)], and cardiovascular function [creatine kinase-MB (CK-MB), hypersensitive troponin Ⅰ (hs-cTnⅠ) and myoglobin (MYO)]were compared between the two groups. Safety was evaluated.
Results Sixty-two cases were enrolled in the treatment group and fifty-eight cases in the control group. After treatment, the total effective rates in the treatment group and the control group were 93.55% (58 cases/62 cases) and 77.59% (45 cases/58 cases), with statistically significant difference (P<0.05). After treatment, serum phosphorus levels in the treatment group and the control group were (1.31±0.16) and (1.50±0.34) mmol·L-1; serum calcium levels were (2.63±0.91) and (2.25±0.72) mmol·L-1; ALP levels were (83.28±8.40) and (126.46±12.39) U·L-1; iPTH levels were (215.32±16.69) and (307.65±20.14) pg·mL-1. The differences were statistically significant (all P<0.05). After treatment, the length of the parathyroid gland in the treatment group and the control group were (0.58±0.10) and (0.77±0.19) cm; width were (0.34±0.08) and (0.45±0.16) cm; thickness were (0.25±0.05) and (0.33±0.15) cm; volume were (0.82±0.15) and (1.13±0.22) cm3. The differences were statistically significant (all P<0.05). After treatment, serum CK-MB levels in the treatment group and the control group were (4.18±0.73) and (6.53±1.26) ng·mL-1; hs-cTnⅠ levels were (0.04±0.01) and (0.07±0.03) ng·mL-1; MYO levels were (70.69±9.41) and (112.39±12.60) ng·mL-1. The differences were statistically significant (all P<0.05). The adverse drug reactions in the treatment group and the control group mainly included nausea and vomiting, increased blood pressure, and myalgia. The total incidence of adverse drug reactions in the treatment group and the control group were 8.06 % (5 cases / 62 cases) and 22.41% (13 cases / 58 cases), respectively, and the difference was statistically significant (P<0.05).
Conclusion Cinacalcet is effective in the treatment of SHPT in patients undergoing hemodialysis for CKD. It can reduce parathyroid gland volume, maintain calcium and phosphorus metabolism, and protect cardiovascular function, with high safety.
, authors=Xian-da XIE, Dai-rong TANG, Qin ZOU, Xiang-wen CHEN, Zhe CHEN, Xiong YAN, Xiang-ping LIAO, authorsList=Xian-da XIE, Dai-rong TANG, Qin ZOU, Xiang-wen CHEN, Zhe CHEN, Xiong YAN, Xiang-ping LIAO, authorCompany=null, correspAuthors=Xiang-ping LIAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404425516536745, articleId=1291404425000637351, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=西那卡塞治疗CKD血液透析继发性甲状旁腺功能亢进患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨西那卡塞治疗慢性肾病（CKD）血液透析继发性甲状旁腺功能亢进（SHPT）患者的临床研究。
方法 将CKD血液透析SHPT患者按队列法分为对照组和试验组。对照组给予骨化三醇胶囊0.25 μg，qd，口服；试验组在对照组治疗的基础上给予西那卡塞片25 mg，qd，口服。2组患者均持续治疗12周。比较2组患者的临床疗效、甲状旁腺体积、甲状旁腺功能[血磷、血钙、碱性磷酸酶（ALP）、全段甲状旁腺激素（iPTH）]、心血管功能[肌酸激酶同工酶（CK-MB）、高敏肌钙蛋白Ⅰ（hs-cTnⅠ）、肌红蛋白（MYO）]，并评价安全性。
结果 试验组和对照组分别入组62和58例。治疗后，试验组和对照组的总有效率分别为93.55％（58例/62例）和77.59％（45例/58例），在统计学上差异有统计学意义（P<0.05）。治疗后，试验组和对照组的血磷水平分别为（1.31±0.16）和（1.50±0.34）mmol·L-1，血钙水平分别为（2.63±0.91）和（2.25±0.72）mmol·L-1，ALP水平分别为（83.28±8.40）和（126.46±12.39）U·L-1，iPTH水平分别为（215.32±16.69）和（307.65±20.14）pg·mL-1，在统计学上差异均有统计学意义（均P<0.05）。治疗后，试验组和对照组的甲状旁腺腺体的长分别为（0.58±0.10）和（0.77±0.19）cm，宽分别为（0.34±0.08）和（0.45±0.16）cm，厚分别为（0.25±0.05）和（0.33±0.15）cm，体积分别为（0.82±0.15）和（1.13±0.22）cm3，在统计学上差异均有统计学意义（均P<0.05）。治疗后，试验组和对照组血清CK-MB水平分别为（4.18±0.73）和（6.53±1.26）ng·mL-1，hs-cTnⅠ水平分别为（0.04±0.01）和（0.07±0.03）ng·mL-1，MYO水平分别为（70.69±9.41）和（112.39±12.60）ng·mL-1，在统计学上差异均有统计学意义（均P<0.05）。试验组和对照组的药物不良反应主要有恶心呕吐、血压增高、肌痛。试验组和对照组的药物不良反应总发生率分别为8.06%（5例/62例）和22.41%（13例/58例），在统计学上差异有统计学意义（P<0.05）。
结论 西那卡塞治疗CKD血液透析SHPT患者的疗效显著，可缩小甲状旁腺体积，维持钙磷代谢，保护心血管功能，且安全性较高。
, authors=谢先达, 唐代荣, 邹琴, 陈香文, 陈喆, 晏雄, 廖湘平, authorsList=谢先达, 唐代荣, 邹琴, 陈香文, 陈喆, 晏雄, 廖湘平, authorCompany=null, correspAuthors=廖湘平, authorNote=
谢先达（1989-），男，主治医师，主要从事肾病学方面的临床研究
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