Article(id=1291404342733562065, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291404284806030089, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.04.025, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1723651200000, receivedDateStr=2024-08-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785824388440, onlineDateStr=2026-08-04, pubDate=1740672000000, pubDateStr=2025-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785824388440, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785824388440, creator=13701087609, updateTime=1785824388440, updator=13701087609, issue=Issue{id=1291404284806030089, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='4', pageStart='451', pageEnd='600', issueExtLink='null', onlineDate='null', pubDate='1740672000000', pubDateStr='2025-02-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785824374629, creator='13701087609', updateTime=1785824374629, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=570, endPage=575, ext={EN=ArticleExt(id=1291404343966687442, articleId=1291404342733562065, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of omics technology in the research of prevention and treatment of pulmonary fibrosis with traditional Chinese medicine, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Pulmonary fibrosis (PF) is a kind of interstitial lung disease with unknown cause. The mechanism of traditional Chinese medicine in the prevention and treatment of PF needs to be strengthened. Traditional Chinese medicine and its compounds can play a therapeutic role in the prevention and treatment of PF from multiple targets and pathways. Because of the complex components of traditional Chinese medicine and single research method, the research process is slow. In recent years, omics technologies (proteomics, metabolomics, transcriptomics, genomics) are helpful to explore and screen clinical biomarkers and new prevention and treatment targets of PF, providing ideas and strategies for the development of targeted traditional Chinese medicine. In this review, we summarize the application of different omics technologies in the research of PF in recent years, and analyze the progress of omics technology in revealing the therapeutic mechanism of traditional Chinese medicine. We also discuss the advantages and limitations of omics technology, and think about the future research direction of PF.

, authors=Ni-ni LIAN^{1, 2}, Ya-li LUO^{1, 2, 3}, Lin-feng RUAN^{1, 2}, Jing LUO^{1, 2}, Li FENG^{1, 2}, Xin-ru DENG^{1, 2}, authorsList=Ni-ni LIAN, Ya-li LUO, Lin-feng RUAN, Jing LUO, Li FENG, Xin-ru DENG, authorCompany=null, correspAuthors=Ya-li LUO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291404345183035603, articleId=1291404342733562065, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=组学技术在中医药防治肺纤维化研究中的应用现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

肺纤维化（PF）是一种原因不明的间质性肺病，中医药防治PF的机制研究有待加强。中药及复方防治PF可从多靶点、多途径上发挥治疗作用，由于中药成分复杂和研究方法单一，使得研究进程缓慢。近年来组学技术（蛋白质组学、代谢组学、转录组学、基因组学）有助于探索并筛选PF的临床生物标志物及防治新靶点，为开展靶向中药研发提供思路和策略。本文将近年来不同组学技术在PF的研究的应用进行小结，同时分析其在揭示中医药疗效机制方面的进展，探讨组学技术的优势与局限，并对未来PF相关研究方向进行思考和展望。

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连妮妮（1990-），女，硕士研究生，主要从事肺系疾病的中医药方面的研究

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连妮妮（1990-），女，硕士研究生，主要从事肺系疾病的中医药方面的研究

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