Article(id=1291339173768721399, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339070622396983, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.03.028, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1720972800000, receivedDateStr=2024-07-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808850948, onlineDateStr=2026-08-04, pubDate=1739721600000, pubDateStr=2025-02-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808850948, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808850948, creator=13041195026, updateTime=1785808850948, updator=13041195026, issue=Issue{id=1291339070622396983, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='3', pageStart='301', pageEnd='450', issueExtLink='null', onlineDate='null', pubDate='1739721600000', pubDateStr='2025-02-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808826353, creator='13041195026', updateTime=1785808826353, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=438, endPage=441, ext={EN=ArticleExt(id=1291339175601632248, articleId=1291339173768721399, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of the Notch signaling pathway in the pathogenesis of rheumatoid arthritis, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Rheumatoid arthritis (RA) is categorized as "bi zheng" and "li-jiebing" in Chinese medicine. Liver and kidney insufficiency, marrow can not nourish the bones, feel the external evil, long-term accumulation in the body, heat into poison, damage to the qi and blood meridians and collaterals, heat and poison, phlegm, blood stasis and paralysis and the onset of the disease, mixed with the real and the imaginary, difficult to be cured. The Notch signaling pathway has a greater relevance to this disease, and it is involved in various pathological processes such as inflammatory cell infiltration, proliferation of fibroblast-like synoviocytes (FLS), microvascular formation and bone destruction. In this paper, the correlation between Notch signaling pathway and this disease is discussed from the perspective of the combination of Chinese and Western medicine, based on the theory of "XU, DU, YU" of traditional Chinese medicine, with the aim of providing a new way of thinking for the research.

, authors=Wen-xia QI¹, Jia WANG¹, Tong HE¹, Jie-xiang TIAN², Tao WANG², Yan-feng YAN³, Yuan-yuan ZHANG², Gang WANG², authorsList=Wen-xia QI, Jia WANG, Tong HE, Jie-xiang TIAN, Tao WANG, Yan-feng YAN, Yuan-yuan ZHANG, Gang WANG, authorCompany=null, correspAuthors=Gang WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339175974925305, articleId=1291339173768721399, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=Notch信号通路在类风湿关节炎病理机制中的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

类风湿关节炎（RA）在中医学属归属于“痹证”“历节病”等范畴，肝肾不足，髓不能养骨，感受外邪，长期郁结于体内，化热成毒，损及气血经络，热毒痰浊瘀血痹阻而发病，虚实夹杂，缠绵难愈。Notch信号通路与本病具有较大的相关性，其参与了炎性细胞浸润、成纤维样滑膜细胞的增殖、微血管的形成及骨质破坏等多种病理过程。本文从中西医结合的角度，基于中医虚、毒、瘀的病机理论，深入探讨Notch信号通路与本病的相关性，以期为研究提供新思路。

, authors=漆文霞¹, 王嘉¹, 贺童¹, 田杰祥², 王涛², 闫彦峰³, 张媛媛², 王钢², authorsList=漆文霞, 王嘉, 贺童, 田杰祥, 王涛, 闫彦峰, 张媛媛, 王钢, authorCompany=null, correspAuthors=王钢, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=9ENCaKYifUzL23Pg6m8UMw==, magXml=J6TZ5YZVzjk7Hnk1ew0ilA==, pdfUrl=null, pdf=sAlS2iMdT6urC+ehDDaTVw==, pdfFileSize=1334757, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=ftKWlewDAjf5x2akrFJEog==, mapNumber=null, fund=null)}, authors=[Author(id=1291339176801202179, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339173768721399, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339176876699653, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339173768721399, authorId=1291339176801202179, language=EN, stringName=Wen-xia QI, firstName=Wen-xia, middleName=null, lastName=QI, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339176960585734, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339173768721399, authorId=1291339176801202179, language=CN, stringName=漆文霞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=^1.甘肃中医药大学 中西医结合学院，甘肃 兰州 730000, bio={"content":"

漆文霞（1995-），女，博士研究生，主要从事中西医结合防治风湿病的相关研究

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漆文霞（1995-），女，博士研究生，主要从事中西医结合防治风湿病的相关研究

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