Article(id=1291339149546615658, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339070622396983, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.03.024, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1721404800000, receivedDateStr=2024-07-20, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808845173, onlineDateStr=2026-08-04, pubDate=1739721600000, pubDateStr=2025-02-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808845173, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808845173, creator=13041195026, updateTime=1785808845173, updator=13041195026, issue=Issue{id=1291339070622396983, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='3', pageStart='301', pageEnd='450', issueExtLink='null', onlineDate='null', pubDate='1739721600000', pubDateStr='2025-02-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808826353, creator='13041195026', updateTime=1785808826353, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=416, endPage=421, ext={EN=ArticleExt(id=1291339149995406187, articleId=1291339149546615658, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of Chinese herbal extracts targeting SIRT1 in the prevention and treatment of diabetic kidney disease, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Diabetic kidney disease (DKD) is one of the major complications caused by diabetes mellitus, due to its insidious onset, complex pathogenesis and not yet fully defined, it is easy to be delayed for a long period of time to progress to end-stage renal disease (ESRD) or even lead to death. DKD is characterized by the progressive aggravation of urinary protein, and is accompanied by different degrees of glomerulosclerosis, tubular dilatation, interstitial fibrosis and other renal pathologic changes. Data show that hyperglycemic state leads to decreased expression of SIRT1, and SIRT1 has been found to improve renal tissue damage and protect renal function. Therefore, SIRT1 may become a potential target for DKD prevention and treatment, inhibiting renal fibrosis and delaying DKD progression by promoting podocyte autophagy, reducing oxidative stress and inflammatory response. In this paper, we focus on the experimental studies of Chinese medicine extracts targeting the SIRT1 signaling pathway to prevent and control DKD, with a view to providing new ideas and reference basis for the clinical treatment of DKD.

, authors=Kun ZHANG¹, Xiao-long MEI¹, Li-hui FAN¹, Lu-mei ZHANG¹, Xia YANG^2a, Zhi-gang WANG^2a, Jian-jun LI^2b, authorsList=Kun ZHANG, Xiao-long MEI, Li-hui FAN, Lu-mei ZHANG, Xia YANG, Zhi-gang WANG, Jian-jun LI, authorCompany=null, correspAuthors=Zhi-gang WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339151161422700, articleId=1291339149546615658, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=中药提取物靶向SIRT1防治糖尿病肾病的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

糖尿病肾病（DKD）是糖尿病导致的主要并发症之一，因其起病隐匿、发病机制复杂且尚未完全明确，容易迁延日久进展为终末期肾病（ESRD）甚至引发死亡。DKD以进行性加重的尿蛋白为主要临床表现，并伴有不同程度的肾小球硬化、肾小管扩张、肾间质纤维化等肾病理改变。数据显示，高血糖状态会导致SIRT1表达降低，且研究发现SIRT1具有改善肾组织损伤、保护肾功能的作用。因此SIRT1可能成为DKD防治的潜在靶点，通过促进足细胞自噬、减少氧化应激和炎症反应抑制肾纤维化，延缓DKD进展。本文着重梳理了中药提取物靶向调节SIRT1信号通路防治DKD的相关实验研究，以期为临床治疗DKD提供新的思路和参考依据。

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张坤（1999-），女，硕士研究生，主要从事内分泌及代谢性疾病中医药防治研究

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张坤（1999-），女，硕士研究生，主要从事内分泌及代谢性疾病中医药防治研究

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