Article(id=1291339243083784473, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339070622396983, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.03.022, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1723651200000, receivedDateStr=2024-08-15, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808867473, onlineDateStr=2026-08-04, pubDate=1739721600000, pubDateStr=2025-02-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808867473, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808867473, creator=13041195026, updateTime=1785808867473, updator=13041195026, issue=Issue{id=1291339070622396983, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='3', pageStart='301', pageEnd='450', issueExtLink='null', onlineDate='null', pubDate='1739721600000', pubDateStr='2025-02-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808826353, creator='13041195026', updateTime=1785808826353, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=406, endPage=409, ext={EN=ArticleExt(id=1291339243314471194, articleId=1291339243083784473, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=New drug for the treatment of chronic respiratory diseases——Itepekimab, columnId=1291339032068354347, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=New Drugs Introduction, runingTitle=null, highlight=null, articleAbstract=

Itepekimab is a human immunoglobulin G (IgG)4P monoclonal antibody targeting interleukin-33 (IL-33), currently under development for treating chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD) and bronchial asthma. It has been shown to significantly reduce the incidence of moderate-to-severe acute exacerbations in COPD, lower the rate of uncontrolled asthma, improve lung function, and enhance quality of life. The drug demonstrates a favorable safety and tolerability profile, with common adverse events including headache, nasopharyngitis, gastrointestinal reactions, back pain, and others. This paper provides an overview of the mechanism of action, pharmacokinetics, pharmacodynamics, animal studies, clinical research, and safety profile of Itepekimab.

, authors=Pan-pan ZHU¹, Rong-fang XIE¹, Zhi-hui LAN², authorsList=Pan-pan ZHU, Rong-fang XIE, Zhi-hui LAN, authorCompany=null, correspAuthors=Zhi-hui LAN, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339243670987035, articleId=1291339243083784473, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=治疗慢性呼吸系统疾病的新药——Itepekimab, columnId=1291339032219349293, journalTitle=中国临床药理学杂志, columnName=新药介绍, runingTitle=null, highlight=null, articleAbstract=

Itepekimab是一种靶向白细胞介素-33（IL-33）的人免疫球蛋白G（IgG）4P单克隆抗体，正开发用于治疗慢性阻塞性肺疾病（COPD）和支气管哮喘等慢性呼吸系统疾病。该药可显著降低COPD中重度急性加重发生率，及哮喘失控率，改善肺功能及生活质量，且安全性和耐受性良好，常见不良事件包括头痛、鼻咽炎、胃肠道反应、背痛等。本文就Itepekimab作用机制、药代动力学、药效学、动物研究、临床研究、安全性进行介绍。

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祝盼盼（1989－），女，博士研究生，主要从事中西医结合治疗慢性肺系疾病的研究

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祝盼盼（1989－），女，博士研究生，主要从事中西医结合治疗慢性肺系疾病的研究

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