Article(id=1291339209416106124, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339070622396983, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.03.012, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1722182400000, receivedDateStr=2024-07-29, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808859446, onlineDateStr=2026-08-04, pubDate=1739721600000, pubDateStr=2025-02-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808859446, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808859446, creator=13041195026, updateTime=1785808859446, updator=13041195026, issue=Issue{id=1291339070622396983, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='3', pageStart='301', pageEnd='450', issueExtLink='null', onlineDate='null', pubDate='1739721600000', pubDateStr='2025-02-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808826353, creator='13041195026', updateTime=1785808826353, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=355, endPage=360, ext={EN=ArticleExt(id=1291339211827830925, articleId=1291339209416106124, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Effects of Venekra on proliferation and apoptosis of acute myeloid leukemia cells, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effect of venetoclax (Vene) on cell proliferation and apoptosis in acute myeloid leukemia (AML) by regulating the microRNA-410-3p (miR-410-3p)/high mobility group protein B1 (HMGB1) axis.
Methods THP1 cells were randomly divided into control group (normal culture), experimental group (100 nmol·L-1 Vene treatment), inh-NC group (experimental group + transfection of inh-miR-410-3p negative control), inh-miR-410-3p group (experimental group + transfection of inh-miR-410-3p), inh-NC combined with sh-NC group (inh-NC group + transfection of sh-HMGB1 negative control), inh-miR-410-3p combined with sh-NC group (inh-miR-410-3p group + transfection of sh-HMGB1 negative control), sh-HMGB1 group (inh-miR-410-3p group + transfection of sh-HMGB1). The relative expression levels of miR-410-3p and HMGB1 mRNA were detected by real-time quantitative polymerase chain reaction; immunofluorescence assay was used to detect the positive expression of HMGB1; 5-ethynyl-2′-deoxyuridine (EdU) was used to detect cell proliferation; Western blot was used to detect the relative expression levels of B lymphocytoma-2 (Bcl-2) and Bcl-2 associated X protein (Bax).
Results The relative expression levels of miR-410-3p in the control group, experimental group, inh-NC group, inh-miR-410-3p group, inh-NC combined with sh-NC group, inh-miR-410-3p combined with sh-NC group and sh-HMGB1 group were 1.00±0.15, 3.76±0.31, 3.64±0.33, 1.69±0.20, 1.00±0.17, 0.42±0.06, 0.89±0.07, respectively; the relative expression levels of HMGB1 mRNA were 1.00±0.13, 0.62±0.07, 0.65±0.06, 0.93±0.11, 1.00±0.15, 1.93±0.21, 1.14±0.16, respectively. The relative fluorescence levels of HMGB1 in the control group, experimental group, inh-NC group and inh-miR-410-3p group were 1.00±0.16, 0.55±0.07, 0.58±0.08, 0.82±0.14, respectively. The cell proliferation rates of inh-NC combined with sh-NC group, inh-miR-410-3p combined with sh-NC group and sh-HMGB1 group were (11.46±1.95)%, (37.82±5.31)%, (16.14±3.05)%, respectively; the relative expression levels of Bcl-2 protein were 1.00±0.14, 4.17±0.39, 1.33±0.18, respectively; the relative expression levels of Bax protein were 1.00±0.16, 0.32±0.08, 0.91±0.13, respectively. The differences of above indexes were statistically significant between control group and the experimental group, between inh-NC group and the inh-miR-410-3p group, between inh-NC combined with sh-NC group and inh-miR-410-3p combined with sh-NC group, between inh-miR-410-3p combined with sh-NC group and the the sh-HMGB1 group (all P<0.001).
Conclusion Vene can inhibit the proliferation of AML cells and induce apoptosis of AML cells by regulating the miR-410-3p/HMGB1 axis.
, authors=Peng WU
1, 2, Hong-lin XIA
2, Chuang-chuang REN
2, Peng YANG
1, authorsList=Peng WU, Hong-lin XIA, Chuang-chuang REN, Peng YANG, authorCompany=null, correspAuthors=Peng YANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339212696051854, articleId=1291339209416106124, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=维奈克拉对急性髓性白血病细胞增殖和凋亡的影响, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 研究维奈克拉（Vene）通过调控微小RNA-410-3p（miR-410-3p）/高迁移率族蛋白B1（HMGB1）轴对急性髓性白血病（AML）细胞增殖和凋亡的影响。
方法 将THP1细胞随机分为对照组（正常培养）、实验组（100 nmol·L-1 Vene处理）、inh-NC组（实验组+转染inh-miR-410-3p阴性对照）、inh-miR-410-3p组（实验组+转染inh-miR-410-3p）、inh-NC联合sh-NC组（inh-NC组+转染sh-HMGB1阴性对照）、inh-miR-410-3p联合sh-NC组（inh-miR-410-3p组+转染sh-HMGB1阴性对照）、sh-HMGB1组（inh-miR-410-3p组+转染sh-HMGB1）。用实时荧光定量聚合酶链反应检测miR-410-3p和HMGB1 mRNA的相对表达水平，用免疫荧光实验检测HMGB1的阳性表达情况，用5-乙炔基-2′-脱氧尿苷（EdU）法检测细胞增殖情况，用蛋白质印迹法检测B淋巴细胞瘤-2（Bcl-2）和Bcl-2相关X蛋白（Bax）的蛋白相对表达水平。
结果 对照组、实验组、inh-NC组、inh-miR-410-3p组、inh-NC联合sh-NC组、inh-miR-410-3p联合sh-NC组、sh-HMGB1组的细胞中miR-410-3p相对表达水平分别为1.00±0.15、3.76±0.31、3.64±0.33、1.69±0.20、1.00±0.17、0.42±0.06、0.89±0.07，HMGB1 mRNA相对表达水平分别为1.00±0.13、0.62±0.07、0.65±0.06、0.93±0.11、1.00±0.15、1.93±0.21、1.14±0.16；对照组、实验组、inh-NC组、inh-miR-410-3p组的HMGB1相对荧光水平分别为1.00±0.16、0.55±0.07、0.58±0.08、0.82±0.14；inh-NC联合sh-NC组、inh-miR-410-3p联合sh-NC组、sh-HMGB1组的细胞增殖率分别为（11.46±1.95）%、（37.82±5.31）%、（16.14±3.05）%，Bcl-2蛋白相对表达水平分别为1.00±0.14、4.17±0.39、1.33±0.18，Bax蛋白相对表达水平分别为1.00±0.16、0.32±0.08、0.91±0.13。对照组的上述指标与实验组比较，inh-miR-410-3p组的上述指标与inh-NC组比较，inh-miR-410-3p联合sh-NC组的上述指标与inh-NC联合sh-NC组比较，sh-HMGB1组的上述指标与inh-miR-410-3p联合sh-NC组比较，在统计学上差异均有统计学意义（均P<0.001）。
结论 Vene可以通过调控miR-410-3p/HMGB1轴抑制AML细胞的增殖、诱导AML细胞的凋亡。
, authors=吴鹏
1, 2, 夏宏林
2, 任创创
2, 杨鹏
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吴鹏（1986-），女，硕士研究生，副主任检验技师，主要从事临床检验诊断学方面的研究
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