Article(id=1291339270426452463, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339070622396983, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.03.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1723824000000, receivedDateStr=2024-08-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808873992, onlineDateStr=2026-08-04, pubDate=1739721600000, pubDateStr=2025-02-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808873992, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808873992, creator=13041195026, updateTime=1785808873992, updator=13041195026, issue=Issue{id=1291339070622396983, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='3', pageStart='301', pageEnd='450', issueExtLink='null', onlineDate='null', pubDate='1739721600000', pubDateStr='2025-02-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808826353, creator='13041195026', updateTime=1785808826353, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=350, endPage=354, ext={EN=ArticleExt(id=1291339270623584752, articleId=1291339270426452463, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Siglec-15 regulates the STAT1/STAT3 pathway to promote the proliferation and migration of hepatocellular carcinoma cells, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective Probing whether salivary acid-binding immunoglobulin-like agglutinin-15 (Siglec-15) promotes hepatocellular carcinoma proliferation and migration by regulating the signal transducer and activator of transcription 1/3 (STAT1/STAT3) pathway.
Methods SMMC-7721 and BEL-7402 cells were divided into empty vector groups: S-NC and B-NC groups (NC siRNA was transfected into SMMC-7721 and BEL-7402 cell, respectively), Siglec-15 knockdown expression group: S-si-Siglec-15-3 and B-si-Siglec-15-3 groups (Siglec-15-3 siRNA was transfected into SMMC-7721 and BEL-7402 cell, respectively). The proliferation ability of the cells were detected by methyl thiazolyl tetrazolium (MTT); the longitudinal and lateral migration ability of the cells were detected by Transwell and scratch assay; the expression of STAT3, phosphorylation of STAT3 (p-STAT3), STAT1, phosphorylation of STAT1 (p-STAT1), Siglec-15 was detected by Western blot.
Results Cell viability values at 24 h in the S-NC group, S-si-Siglec-15-3 group, B-NC group and B-si-Siglec-15-3 group were 0.93±0.01, 0.87±0.03, 0.96±0.03 and 0.83±0.02, respectively; the vertical migration rates of cells were 100.00%, 36.40%, 100.00% and 52.20%, respectively; the healing rate of cell scratches at 24 h were (0.76±0.02)%, (0.53±0.02)%, (0.44±0.02)% and (0.36±0.03)%, respectively; STAT3 protein expression levels were 1.11±0.05, 0.66±0.05, 1.07±0.14 and 0.49±0.04, respectively; p-STAT3 protein expression levels were 1.07±0.04, 0.16±0.06, 0.78±0.05 and 0.32±0.03, respectively; STAT1 protein expression levels were 1.32±0.04, 0.71±0.04, 0.91±0.03 and 0.61±0.04, respectively; p-STAT1 protein expression levels were 0.99±0.04, 0.29±0.05, 0.67±0.04 and 0.20±0.06, respectively; Siglec-15 protein expression levels were 1.51±0.04, 0.93±0.05, 0.73±0.02 and 0.12±0.01, respectively. The differences between the S-si-Siglec-15-3 group and the S-NC group, between the B-si-Siglec-15-3 group and the B-NC group were statistically significant in all comparisons (P<0.05, P<0.01, P<0.001).
Conclusion Siglec-15 promotes the proliferation and migration ability of hepatocellular carcinoma cells through the STAT1/STAT3 pathway.
, authors=Jia-wei YAN
1, Lu-lu GUAN
2a, Cai-ru GUO
2b, Jin-yan WANG
2c, Ya-li ZHANG
2c, Xue-jun WEN
3, Zi-li JIN
2c, Min QI
2a, 2c, authorsList=Jia-wei YAN, Lu-lu GUAN, Cai-ru GUO, Jin-yan WANG, Ya-li ZHANG, Xue-jun WEN, Zi-li JIN, Min QI, authorCompany=null, correspAuthors=Min QI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339270992683505, articleId=1291339270426452463, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=Siglec-15调节STAT1/STAT3通路促进肝癌细胞增殖和迁移的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究唾液酸结合性免疫球蛋白样凝集素-15（Siglec-15）是否通过调节信号传导与转录激活因子1/3（STAT1/STAT3）通路促进肝细胞癌的增殖和迁移。
方法 将SMMC-7721细胞分为S-NC组（NC siRNA转染至SMMC-7721细胞）和S-si-Siglec-15-3组（Siglec-15-3 siRNA转染至SMMC-7721细胞），将BEL-7402细胞分为B-NC组（NC siRNA转染至BEL-7402细胞）和B-si-Siglec-15-3组（Siglec-15-3 siRNA转染至BEL-7402细胞）。用噻唑蓝（MTT）法检测细胞的增殖能力；用Transwell小室和划痕试验检测细胞的纵向和横向迁移能力；用蛋白质印迹法检测细胞中STAT3、磷酸化STAT3（p-STAT3）、STAT1、磷酸化STAT1（p-STAT1）、Siglec-15蛋白相对表达水平。
结果 S-NC组、S-si-Siglec-15-3组、B-NC组、B-si-Siglec-15-3组在24 h时的细胞活力值分别为0.93±0.01、0.87±0.03、0.96±0.03、0.83±0.02；细胞纵向迁移率分别为100.00%、36.40%、100.00%、52.20%；24 h的细胞划痕愈合率分别为（0.76±0.02）%、（0.53±0.02）%、（0.44±0.02）%、（0.36±0.03）%；STAT3蛋白相对表达水平分别为1.11±0.05、0.66±0.05、1.07±0.14、0.49±0.04；p-STAT3蛋白相对表达水平分别为1.07±0.04、0.16±0.06、0.78±0.05、0.32±0.03；STAT1蛋白相对表达水平分别为1.32±0.04、0.71±0.04、0.91±0.03、0.61±0.04；p-STAT1蛋白的表达水平分别为0.99±0.04、0.29±0.05、0.67±0.04、0.20±0.06；Siglec-15蛋白相对表达水平分别为1.51±0.04、0.93±0.05、0.73±0.02、0.12±0.01。S-si-Siglec-15-3组与S-NC组比较，在统计学上差异均有统计学意义（P<0.05，P<0.01，P<0.001）；B-si-Siglec-15-3组与B-NC组比较，在统计学上差异均有统计学意义（P<0.05，P<0.01，P<0.001）。
结论 Siglec-15通过STAT1/STAT3通路促进肝癌细胞的增殖、迁移能力。
, authors=闫家伟
1, 关璐璐
2a, 郭彩茹
2b, 王金艳
2c, 张亚丽
2c, 文学军
3, 金自立
2c, 亓民
2a, 2c, authorsList=闫家伟, 关璐璐, 郭彩茹, 王金艳, 张亚丽, 文学军, 金自立, 亓民, authorCompany=null, correspAuthors=亓民, authorNote=
闫家伟（1996-），男，硕士研究生，主要从事消化系统疾病方面的研究
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1.Xinxiang Medical University Graduate School, Xinxiang 453003, Henan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339272024482309, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339270426452463, authorId=1291339271856710146, language=CN, stringName=闫家伟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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1.新乡医学院 研究生院，河南 新乡 453003, bio={"content":"
闫家伟（1996-），男，硕士研究生，主要从事消化系统疾病方面的研究
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2a.Key Laboratory of Individualized Liver Cancer Treatment, Luoyang Central Hospital, Luoyang 471000, Henan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339273811255818, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339270426452463, authorId=1291339272091591175, language=CN, stringName=关璐璐, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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2a.洛阳市中心医院，洛阳市肝癌个体化治疗重点实验室，河南 洛阳 471000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339271470834165, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339270426452463, xref=2a., ext=[AuthorCompanyExt(id=1291339271479222774, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339270426452463, companyId=1291339271470834165, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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2b.Henan International Joint Laboratory of Tumor Cellular Immunity and Regenerative Medicine, Luoyang Central Hospital, Luoyang 471000, Henan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339274029359631, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339270426452463, authorId=1291339273878364684, language=CN, stringName=郭彩茹, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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2b.洛阳市中心医院，河南省肿瘤细胞免疫与再生医学国际联合实验室，河南 洛阳 471000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339271592468984, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339270426452463, xref=2b., ext=[AuthorCompanyExt(id=1291339271600857593, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339270426452463, companyId=1291339271592468984, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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2b.洛阳市中心医院，河南省肿瘤细胞免疫与再生医学国际联合实验室，河南 洛阳 471000)])]), Author(id=1291339274130022929, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339270426452463, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339274260046355, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339270426452463, authorId=1291339274130022929, language=EN, stringName=Jin-yan WANG, firstName=Jin-yan, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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2c.Department of Geriatrics, Luoyang Central Hospital, Luoyang 471000, Henan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339274327155220, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339270426452463, authorId=1291339274130022929, language=CN, stringName=王金艳, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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3.Key Laboratory of Regenerative Medicine, University of Virginia, Charlottesville 22093, USA, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339274721419806, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339270426452463, authorId=1291339274578813467, language=CN, stringName=文学军, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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