Article(id=1291339163001934704, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339070622396983, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.03.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1722441600000, receivedDateStr=2024-08-01, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808848381, onlineDateStr=2026-08-04, pubDate=1739721600000, pubDateStr=2025-02-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808848381, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808848381, creator=13041195026, updateTime=1785808848381, updator=13041195026, issue=Issue{id=1291339070622396983, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='3', pageStart='301', pageEnd='450', issueExtLink='null', onlineDate='null', pubDate='1739721600000', pubDateStr='2025-02-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808826353, creator='13041195026', updateTime=1785808826353, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=311, endPage=315, ext={EN=ArticleExt(id=1291339163186484081, articleId=1291339163001934704, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of insulin degludec/insulin aspart combined with metformin in the treatment of insulin resistance in T2DM patients, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the effect of insulin degludec/insulin aspart injection combined with metformin extended-release tablets on insulin resistance in patients with type 2 diabetes mellitus (T2DM).
Methods T2DM patients were divided into control group and treatment group using a cohort method. The control group received oral metformin extended-release tablets (0.5 g, tid) and subcutaneous injections of insulin glargine injection (10 U, qd), while the treatment group received oral metformin extended-release tablets (0.5 g, tid) and subcutaneous injections of insulin degludec/insulin aspart injection (0.1-0.2 U·kg-1·d-1, evenly divided before breakfast and dinner). Both groups were treated for 12 weeks. The efficacy, blood glucose control [fasting blood glucose, 2-hour postprandial blood glucose, glycated hemoglobin A1c(HbA1c)], insulin function [fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment-β (HOMA-β)]were compared, and safety was evaluated.
Results A total of 49 cases were enrolled in the treatment group and 51 cases in the control group. The overall effective rates in the treatment and control groups were 93.88% (46 cases/49 cases) and 80.39% (41 cases/51 cases), respectively, showing a statistically significant difference (P<0.05). After treatment, the fasting blood glucose levels in the treatment and control groups were (5.83±0.79) and (6.53±0.81) mmol·L-1; the 2-hour postprandial blood glucose levels were (7.73±0.86) and (8.41±0.97) mmol·L-1; HbA1c levels were (6.34±0.88)% and (6.80±0.92)%; FINS levels were (6.02±1.13) and (7.13±1.04) mU·L-1; HOMA-IR values were 1.56±0.20 and 2.07±0.23; HOMA-β values were 51.67±3.18 and 47.06±3.31, respectively, with all differences being statistically significant (all P<0.05). The adverse drug reactions in the treatment group mainly included hypoglycemia, nausea, dizziness, and diarrhea, while the adverse drug reactions in the control group mainly included hypoglycemia and nausea. The incidence of adverse drug reactions was 10.20% (5 cases/49 cases) in the treatment group and 11.76% (6 cases /51 cases) in the control group, with no statistically significant difference (P<0.05).
Conclusion The combination of insulin degludec/insulin aspart injection and metformin extended-release tablets can improve insulin resistance and regulate blood glucose levels in T2DM patients, with good safety profiles.
, authors=Zhen ZHENG, Ning-ning YANG, Xue-ming FAN, authorsList=Zhen ZHENG, Ning-ning YANG, Xue-ming FAN, authorCompany=null, correspAuthors=Zhen ZHENG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339163542999922, articleId=1291339163001934704, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=德谷门冬双胰岛素联合二甲双胍治疗T2DM患者胰岛素抵抗的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 分析德谷门冬双胰岛素注射液联合二甲双胍缓释片对2型糖尿病（T2DM）患者胰岛素抵抗的影响。
方法 将T2DM患者按照队列法分为对照组和试验组。对照组患者口服二甲双胍缓释片（每次0.5 g，tid）及皮下注射甘精胰岛素注射液（10 U，qd）治疗，试验组口服二甲双胍缓释片（每次0.5 g，tid）及皮下注射德谷门冬双胰岛素注射液（0.1~0.2 U·kg-1·d-1，早晚餐前平均分配）治疗，2组均治疗12周。比较2组患者疗效，比较血糖控制情况[空腹血糖、餐后2 h血糖、糖化血红蛋白（HbA1c）]、胰岛素功能情况[空腹胰岛素（FINS）、胰岛素抵抗指数（HOMA-IR）、胰岛β细胞功能（HOMA-β）]及进行安全性评价。
结果 试验组和对照组分别入组49和51例。试验组和对照组总有效率分别为93.88%（46例/49例）和80.39%（41例/51例），在统计学上差异有统计学意义（P<0.05）。治疗后，试验组和对照组的空腹血糖分别为（5.83±0.79）和（6.53±0.81）mmol·L-1，餐后2 h血糖分别为（7.73±0.86）和（8.41±0.97）mmol·L-1，HbA1c分别为（6.34±0.88）%和（6.80±0.92）%，FINS分别为（6.02±1.13）和（7.13±1.04）mU·L-1，HOMA-IR分别为1.56±0.20和2.07±0.23，HOMA-β分别为51.67±3.18和47.06±3.31，在统计学上差异均有统计学意义（均P<0.05）。试验组的药物不良反应主要为低血糖、恶心、头晕、腹泻；对照组的药物不良反应主要为低血糖、恶心。试验组和对照组的药物不良反应总发生率分别为10.20%（5例/49例）和11.76%（6例/51例），在统计学上差异无统计学意义（P>0.05）。
结论 德谷门冬双胰岛素注射液联合二甲双胍缓释片治疗能改善T2DM患者胰岛素抵抗和调节血糖水平，安全性较好。
, authors=郑振, 杨宁宁, 范学明, authorsList=郑振, 杨宁宁, 范学明, authorCompany=null, correspAuthors=郑振, authorNote=
郑振（1986-），男，副主任医师，主要从事内分泌及代谢病方面的工作
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