Article(id=1291339133226570431, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291339021272211834, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.02.011, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1721145600000, receivedDateStr=2024-07-17, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808841189, onlineDateStr=2026-08-04, pubDate=1737993600000, pubDateStr=2025-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808841189, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808841189, creator=13041195026, updateTime=1785808841189, updator=13041195026, issue=Issue{id=1291339021272211834, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='2', pageStart='151', pageEnd='300', issueExtLink='null', onlineDate='null', pubDate='1737993600000', pubDateStr='2025-01-28', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808814590, creator='13041195026', updateTime=1785808814590, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=203, endPage=208, ext={EN=ArticleExt(id=1291339135571186368, articleId=1291339133226570431, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research of xanthine in the treatment of rats with allergic rhinitis complicated with asthma, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the mechanism of action of tanthine in the treatment of allergic rhinitis (AR) complicated with asthma in rats by regulating microRNA-27a-3p (miR-27a-3p) targeting thymic stromal lymphopoietin (TSLP).
Methods The AR-asthma rat model was established using ovalbumin (OVA) sensitization and nasal drip attack method. Fifty rats were divided into control group (equal volume 0.9% NaCl), model group (AR-asthma model+equal volume 0.9% NaCl), experimental group (AR-asthma model+100 mg·kg-1 xanthortin) and miR-27a-3p inhibitor group (caudal vein injection of 0.5 nmol·μL-1 miR-27a-3p inhibitor 10 μL on the basis of the experimental group), si-TSLP group (0.5 nmol·μL-1 si-TSLP 10 μL intravenously injected on the basis of miR-27a-3p inhibitor group), 10 rats in each group. Serum immunoglobulin E (IgE), interleukin-2 (IL-2), IL-13 and tumor necrosis factor-α (TNF-α) levels of rats were detected by enzyme-linked immunosorbent assay. The level of superoxide dismutase (SOD) was detected by xanthoxine oxidase method. The level of malonaldehyde (MDA) was detected by thiobarbituric acid method (TBA).
Results The levels of IgE in control group, model group, experimental group, miR-27a-3p inhibitor group and si-TSLP group were (18.33±3.53), (89.95±17.62), (55.70±10.08), (78.43±15.30) and (47.87±9.44) ng·mL-1, respectively; IL-2 levels were (8.01±1.36), (19.61±3.94), (14.12±2.51), (17.33±3.18) and (11.89±2.03) pg·mL-1, respectively; IL-13 levels were (6.79±1.33), (34.15±7.02), (24.70±5.13), (35.97±7.24) and (20.53±4.26) pg·mL-1, respectively; TNF-α levels were (94.08±19.07), (312.47±58.61), (209.78±41.49), (296.42±55.99) and (187.45±37.28) pg·mL-1, respectively; SOD levels were (29.14±5.04), (13.25±2.63), (24.19±4.89), (17.28±3.16) and (33.94±5.87) U·mg prot-1, respectively; MDA levels were (2.26±0.51), (4.43±0.72), (3.17±0.58), (3.94±0.69) and (2.62±0.45) nmol·m gprot-1, respectively. The above indicators were compared between control group and model group, model group and experimental group, experimental group and miR-27a-3p inhibitor group, miR-27a-3p inhibitor group and si-TSLP group. The differences were statistically significant (all P<0.05).
Conclusion Xanthine can improve oxidative stress and reduce inflammation of AR complicated with asthma in rats, and its mechanism may be related to the regulation of miR-27a-3p targeting TSLP.
, authors=Bing ZHANG, Yan-xia ZHANG, Xiang-dong YAO, authorsList=Bing ZHANG, Yan-xia ZHANG, Xiang-dong YAO, authorCompany=null, correspAuthors=Bing ZHANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339135982228161, articleId=1291339133226570431, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=苍耳亭治疗过敏性鼻炎合并哮喘大鼠的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨苍耳亭通过调节微小RNA（miR）-27a-3p靶向胸腺基质淋巴细胞生成素（TSLP）治疗过敏性鼻炎（AR）合并哮喘的作用机制。
方法 用卵清蛋白（OVA）致敏和鼻部滴注攻击法建立AR合并哮喘大鼠模型。将50只大鼠分为对照组（等体积0.9% NaCl）、模型组（构建AR模型合并哮喘+等体积0.9% NaCl）、实验组（构建AR模型合并哮喘+100 mg·kg-1苍耳亭）、miR-27a-3p inhibitor组（在实验组基础上尾静脉注射0.5 nmol·μL-1 miR-27a-3p inhibitor 10 μL），si-TSLP组（在miR-27a-3p inhibitor组基础上尾静脉注射0.5 nmol·μL-1 si-TSLP 10 μL），每组10只。用酶联免疫吸附试验法检测大鼠血清免疫球蛋白E（IgE）、白细胞介素-2（IL-2）、IL-13和肿瘤坏死因子-α（TNF-α）的水平，用黄嘌呤氧化酶法检测超氧化物歧化酶（SOD）水平，用硫代巴比妥酸法（TBA）检测丙二醛（MDA）水平。
结果 对照组、模型组、实验组、miR-27a-3p inhibitor组和si-TSLP组的IgE水平分别为（18.33±3.53）、（89.95±17.62）、（55.70±10.08）、（78.43±15.30）和（47.87±9.44）ng·mL-1，IL-2水平分别为（8.01±1.36）、（19.61±3.94）、（14.12±2.51）、（17.33±3.18）和（11.89±2.03）pg·mL-1，IL-13水平分别为（6.79±1.33）、（34.15±7.02）、（24.70±5.13）、（35.97±7.24）和（20.53±4.26）pg·mL-1，TNF-α水平分别为（94.08±19.07）、（312.47±58.61）、（209.78±41.49）、（296.42±55.99）和（187.45±37.28）pg·mL-1，SOD水平分别为（29.14±5.04）、（13.25±2.63）、（24.19±4.89）、（17.28±3.16）和（33.94±5.87）U·mg prot-1，MDA水平分别为（2.26±0.51）、（4.43±0.72）、（3.17±0.58）、（3.94±0.69）和（2.62±0.45）nmol·mg prot-1。对照组的上述指标与模型组比较，模型组的上述指标与实验组比较，实验组的上述指标与miR-27a-3p inhibitor组比较，miR-27a-3p inhibitor组的上述指标与si-TSLP组比较，在统计学上差异均有统计学意义（P<0.05，P<0.01）。
结论 苍耳亭对大鼠的AR合并哮喘具有改善氧化应激、减轻炎症的治疗作用，其机制可能与调节miR-27a-3p靶向TSLP有关。
, authors=张冰, 张燕霞, 姚向东, authorsList=张冰, 张燕霞, 姚向东, authorCompany=null, correspAuthors=张冰, authorNote=
张冰（1987-），男，主治医师，主要从事过敏性鼻炎的相关机制研究
, correspAuthorsNote=
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=iWvVpmNU9jLmFcS1ZuibPg==, magXml=6kJlL0OZssw72Y+oDWaaCg==, pdfUrl=null, pdf=OxaPk1QEGMfCPVnAiaEySA==, pdfFileSize=1458496, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=at9nJ3PlsGu5w7fikrjPxg==, mapNumber=null, fund=null)}, authors=[Author(id=1291339136292606663, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=zhangbing137819@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1291339136372298441, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, authorId=1291339136292606663, language=EN, stringName=Bing ZHANG, firstName=Bing, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Otolaryngology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339136464573130, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, authorId=1291339136292606663, language=CN, stringName=张冰, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=新乡市中心医院/新乡医学院 第四临床学院 耳鼻咽喉科，河南 新乡 453000, bio={"content":"
张冰（1987-），男，主治医师，主要从事过敏性鼻炎的相关机制研究
"}, bioImg=null, bioContent=
张冰（1987-），男，主治医师，主要从事过敏性鼻炎的相关机制研究
, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339136208720579, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, xref=null, ext=[AuthorCompanyExt(id=1291339136217109188, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, companyId=1291339136208720579, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Otolaryngology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China), AuthorCompanyExt(id=1291339136229692101, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, companyId=1291339136208720579, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=新乡市中心医院/新乡医学院 第四临床学院 耳鼻咽喉科，河南 新乡 453000)])]), Author(id=1291339136561042124, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339136632345294, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, authorId=1291339136561042124, language=EN, stringName=Yan-xia ZHANG, firstName=Yan-xia, middleName=null, lastName=ZHANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Otolaryngology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339136699454159, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, authorId=1291339136561042124, language=CN, stringName=张燕霞, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=新乡市中心医院/新乡医学院 第四临床学院 耳鼻咽喉科，河南 新乡 453000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339136208720579, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, xref=null, ext=[AuthorCompanyExt(id=1291339136217109188, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, companyId=1291339136208720579, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Otolaryngology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China), AuthorCompanyExt(id=1291339136229692101, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, companyId=1291339136208720579, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=新乡市中心医院/新乡医学院 第四临床学院 耳鼻咽喉科，河南 新乡 453000)])]), Author(id=1291339136837866194, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291339136925946580, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, authorId=1291339136837866194, language=EN, stringName=Xiang-dong YAO, firstName=Xiang-dong, middleName=null, lastName=YAO, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Otolaryngology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1291339136993055445, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, authorId=1291339136837866194, language=CN, stringName=姚向东, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=新乡市中心医院/新乡医学院 第四临床学院 耳鼻咽喉科，河南 新乡 453000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1291339136208720579, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, xref=null, ext=[AuthorCompanyExt(id=1291339136217109188, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, companyId=1291339136208720579, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Otolaryngology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China), AuthorCompanyExt(id=1291339136229692101, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, companyId=1291339136208720579, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=新乡市中心医院/新乡医学院 第四临床学院 耳鼻咽喉科，河南 新乡 453000)])])], keywords=[Keyword(id=1291339137085330134, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, language=EN, orderNo=1, keyword=xanthatin), Keyword(id=1291339137148244695, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, language=EN, orderNo=2, keyword=allergic rhinitis), Keyword(id=1291339137248907992, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, language=EN, orderNo=3, keyword=bronchial asthma), Keyword(id=1291339137332794073, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, language=EN, orderNo=4, keyword=oxidative stress), Keyword(id=1291339137399902938, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, language=EN, orderNo=5, keyword=inflammatory factor), Keyword(id=1291339137471206107, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, language=CN, orderNo=1, keyword=苍耳亭), Keyword(id=1291339137534120668, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, language=CN, orderNo=2, keyword=过敏性鼻炎), Keyword(id=1291339137613812445, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, language=CN, orderNo=3, keyword=支气管哮喘), Keyword(id=1291339137718670046, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, language=CN, orderNo=4, keyword=氧化应激), Keyword(id=1291339137802556127, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, language=CN, orderNo=5, keyword=炎症因子)], refs=null, funds=null, companyList=[AuthorCompany(id=1291339136208720579, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, xref=null, ext=[AuthorCompanyExt(id=1291339136217109188, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, companyId=1291339136208720579, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Otolaryngology, Xinxiang Central Hospital/The Fourth Clinical College of Xinxiang Medical College, Xinxiang 453000, Henan Province, China), AuthorCompanyExt(id=1291339136229692101, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291339133226570431, companyId=1291339136208720579, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=新乡市中心医院/新乡医学院 第四临床学院 耳鼻咽喉科，河南 新乡 453000)])], figs=null, attaches=null, journal=Journal(id=1246415058658443328, delFlag=0, nameCn=中国临床药理学杂志, nameEn=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, issn=1001-6821, eissn=null, cn=11-2220/R, coden=null, periodic=3, language=CN, oaType=null, ccby=null, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=8cEfS7jvj/ukyhKVOMJePA==, journalPrice=null, startedYear=null, abbrevIsoEn=Chinese Journal of Clinical Pharmacology, journalRemark=null, publicationField=null, createdTime=1775098107259, updatedTime=1784020014723, createdBy=18614031015, updatedBy=13041195026, firstLetterCn=Z, firstLetterEn=Z, subjectCode=Life Sciences, subjectName=null, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=8cEfS7jvj/ukyhKVOMJePA==, picEn=cQ12tu98gbNetbFuefeYGg==, jcr=null, cjcr=null, exts=[JournalExt(id=1283836250926859016, language=CN, name=中国临床药理学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014745, updatedTime=1784020014745, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""}), JournalExt(id=1283836250981384969, language=EN, name=Chinese Journal of Clinical Pharmacology, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1784020014758, updatedTime=1784020014758, createdBy=13041195026, updatedBy=13041195026, submissionGuidelinesUrl=, submissionAuthorUrl=https://lcylauthor.cast.org.cn/webm, submissionEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionReviewUrl=https://lcylauthor.cast.org.cn/webm, submissionCeEditorUrl=https://lcyleditor.cast.org.cn/webm, submissionAeEditorUrl=https://lcyleditor.cast.org.cn/webm, option={"copyright":""})], databaseList=null, tenantJournalId=1246415772164075586, websiteList=[Website(id=1246421196657546140, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN, language=CN, createTime=1775099570670, createBy=18614031015, updateTime=1775099747371, updateBy=18614031015, name=中国临床药理学杂志-中文, tplId=1146099689490845704, title=中国临床药理学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422027293316008, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=articleTextType, value=kx, createTime=1775099768708, updateTime=1775099768708, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027268150181, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=banner, value=null, createTime=1775099768702, updateTime=1775099768702, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027310093227, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=grayFlag, value=0, createTime=1775099768712, updateTime=1775099768712, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027259761572, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099768700, updateTime=1775099768700, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027322676141, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=minRunFlag, value=0, createTime=1775099768715, updateTime=1775099768715, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027284927399, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/file/pic, createTime=1775099768706, updateTime=1775099768706, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027318481836, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=silenceFlag, value=0, createTime=1775099768714, updateTime=1775099768714, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027276538790, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1775099768704, updateTime=1775099768704, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027297510313, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeColor, value=null, createTime=1775099768709, updateTime=1775099768709, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422027305898922, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196657546140, code=themeStyle, value=null, createTime=1775099768711, updateTime=1775099768711, creator=18614031015, updator=18614031015)]), Website(id=1246421196871455649, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1246415772164075586, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN, language=EN, createTime=1775099570720, createBy=18614031015, updateTime=1775099757298, updateBy=18614031015, name=中国临床药理学杂志-英文, tplId=1146101810881728533, title=Chinese Journal of Clinical Pharmacology, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1246422058998059954, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=articleTextType, value=kx, createTime=1775099776267, updateTime=1775099776267, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058977088431, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=banner, value=null, createTime=1775099776262, updateTime=1775099776262, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059014837173, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=grayFlag, value=0, createTime=1775099776271, updateTime=1775099776271, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058968699822, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=logo, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic?fileId=KeUk4pyVjfIIkOq40uZX0Q==, createTime=1775099776260, updateTime=1775099776260, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059031614391, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=minRunFlag, value=0, createTime=1775099776275, updateTime=1775099776275, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058993865649, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/file/pic, createTime=1775099776266, updateTime=1775099776266, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059023225782, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=silenceFlag, value=0, createTime=1775099776273, updateTime=1775099776273, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422058985477040, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1775099776264, updateTime=1775099776264, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059002254259, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeColor, value=null, createTime=1775099776268, updateTime=1775099776268, creator=18614031015, updator=18614031015), WebsiteProps(id=1246422059010642868, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1246421196871455649, code=themeStyle, value=null, createTime=1775099776270, updateTime=1775099776270, creator=18614031015, updator=18614031015)])], journalTitle=中国临床药理学杂志, weixinUrl=null, journalUrl=null, iacademicId=null, status=1, seqNo=null, journalTitleEn=Chinese Journal of Clinical Pharmacology, journalPhotoCn=8cEfS7jvj/ukyhKVOMJePA==, journalPhotoEn=cQ12tu98gbNetbFuefeYGg==, journalFirstLetter=Z, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false, interPubPlatform=, interPubPlatformUrl=null), detailUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/10.13699/j.cnki.1001-6821.2025.02.011, detailUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/10.13699/j.cnki.1001-6821.2025.02.011, pdfUrlCn=https://castjournals.cast.org.cn/joweb/zglcylxzz/CN/PDF/10.13699/j.cnki.1001-6821.2025.02.011, pdfUrlEn=https://castjournals.cast.org.cn/joweb/zglcylxzz/EN/PDF/10.13699/j.cnki.1001-6821.2025.02.011, aliStartDate=0, aliEndDate=0, collectionFlag=false, citedCount=null, citedUrl=null, previewStatus=0, delFlag=0, hasFullText=0, orderTime=1737993600000, fullTextJson=null, articleText=null, reference=null)
全屏
文章导航
PDF下载
6
2
关闭全屏
北京市海淀区学院南路86号
010-62199257（仅加盟咨询）
qkjq@cast.org.cn
