Article(id=1291339018042597722, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291338935477724120, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.01.024, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1716566400000, receivedDateStr=2024-05-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808813819, onlineDateStr=2026-08-04, pubDate=1737043200000, pubDateStr=2025-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808813819, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808813819, creator=13041195026, updateTime=1785808813819, updator=13041195026, issue=Issue{id=1291338935477724120, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='1', pageStart='1', pageEnd='148', issueExtLink='null', onlineDate='null', pubDate='1737043200000', pubDateStr='2025-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808794022, creator='13041195026', updateTime=1785808794022, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=116, endPage=120, ext={EN=ArticleExt(id=1291339018239730011, articleId=1291339018042597722, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Exploration the role of intestinal flora in drug-induced liver injury based on the gut-liver axis, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Drug-induced liver injury (DILI) is a common adverse drug reactions in clinical practice, with complex pathophysiological process, the pathogenesis has not been fully elucidated, and lack of objective and specific diagnostic methods and treatment, so the prevention and treatment of DILI has attracted extensive attention from scholars. In recent years, the intestinal flora has become a research hotspot in the field of DILI, and the intestinal flora causes or exacerbates DILI by damaging the intestinal mucosal barrier, affecting the metabolites of the intestinal flora and mediating the immune response, and the gut-liver axis is an important pathway for the intestinal flora to participate in the occurrence of DILI, regulating intestinal flora is practicable in the treatment of DILI. This article reviews the characteristics of intestinal flora in DILI patients, and to explore the possible mechanisms of intestinal flora participating in the pathogenesis of DILI through the gut-liver axis, summarizes the latest progress of intervention in the treatment of DILI by intestinal flora, in order to provide references for the screening of the diagnostic targets of DILI and its prevention and treatment from the perspective of intestinal flora.

, authors=Wei ZHOU^1a, Yue-zhen HE^1b, Yan-ling LIU^1a, authorsList=Wei ZHOU, Yue-zhen HE, Yan-ling LIU, authorCompany=null, correspAuthors=Wei ZHOU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339018873069916, articleId=1291339018042597722, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=基于肠-肝轴探讨肠道菌群在药物性肝损伤中的作用, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

药物性肝损伤（DILI）是临床常见的药物不良反应，病理生理过程复杂，发病机制尚不明确，且缺乏客观特异的诊断方法和治疗手段，因此，预防和治疗DILI引起了学者广泛关注。近年来，肠道菌群成为DILI领域研究热点，肠道菌群通过损伤肠黏膜屏障、影响肠道菌群代谢物及介导免疫反应引起或加重DILI，肠-肝轴是肠道菌群参与DILI发病的重要途径，通过调节肠道菌群治疗DILI切实可行。本文综述DILI患者肠道菌群特征，探讨肠道菌群通过肠-肝轴参与DILI发病的可能机制，总结干预肠道菌群治疗DILI的最新进展，从肠道菌群视角为DILI诊断靶点筛选和防治提供参考。

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周伟（1984-），男，副主任检验师，主要从事肝病实验室诊断及研究

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周伟（1984-），男，副主任检验师，主要从事肝病实验室诊断及研究

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