Article(id=1291338947737678621, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291338935477724120, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.01.023, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1719244800000, receivedDateStr=2024-06-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808796955, onlineDateStr=2026-08-04, pubDate=1737043200000, pubDateStr=2025-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808796955, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808796955, creator=13041195026, updateTime=1785808796955, updator=13041195026, issue=Issue{id=1291338935477724120, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='1', pageStart='1', pageEnd='148', issueExtLink='null', onlineDate='null', pubDate='1737043200000', pubDateStr='2025-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808794022, creator='13041195026', updateTime=1785808794022, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=111, endPage=115, ext={EN=ArticleExt(id=1291338949033718558, articleId=1291338947737678621, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of lactate regulation of chronic liver disease, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Excessive fat accumulation, viral infections and sustained inflammatory responses caused by non-alcoholic and alcoholic factors can contribute to liver inflammation, fibrosis and carcinogenesis, promoting the development of chronic liver disease. Gaining an in-depth understanding of the etiologic factors and underlying mechanisms that lead to chronic liver disease can help identify potential therapeutic targets for targeted therapy. Lactate, as an important substance in hepatic metabolism, has been found to be involved in the process of chronic liver disease through various pathways, and this review will provide a useful reference for the prevention and treatment of chronic liver disease.

, authors=Lei WANG^{1a, 1b}, Jia-xin BAI^1b, Yu-ling ZHUANG^1b, Jia-hui WANG^1b, Tie-jian ZHAO^1b, Na HUANG^1b, Yang ZENG^1b, Hua-ye XIAO^1b, authorsList=Lei WANG, Jia-xin BAI, Yu-ling ZHUANG, Jia-hui WANG, Tie-jian ZHAO, Na HUANG, Yang ZENG, Hua-ye XIAO, authorCompany=null, correspAuthors=Hua-ye XIAO, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291338953563566879, articleId=1291338947737678621, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=乳酸调控慢性肝病的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

脂肪堆积过多、病毒感染以及非酒精性和酒精性因素引起的持续炎症反应会导致肝炎症、纤维化和癌变，促进慢性肝病的发展。深入了解导致慢性肝病的病因和内在机制，有助于确定潜在的靶向治疗目标。乳酸作为肝代谢中的一种重要物质，可以通过多种途径参与慢性肝病的进程，本综述将为慢性肝病防治提供有益参考。

, authors=汪磊^{1a, 1b}, 白佳鑫^1b, 庄玉玲^1b, 王佳慧^1b, 赵铁建^1b, 黄娜^1b, 郑洋^1b, 肖华业^1b, authorsList=汪磊, 白佳鑫, 庄玉玲, 王佳慧, 赵铁建, 黄娜, 郑洋, 肖华业, authorCompany=null, correspAuthors=肖华业, authorNote=, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=Uqky803iFvGG9pLlBIm2OA==, magXml=3+IXMEeErrs1YvpNIk/oGw==, pdfUrl=null, pdf=c428oQrnSORVXuSiQjoO+g==, pdfFileSize=1217750, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=KnxHtSUdhJ5fW60g+AcqtA==, mapNumber=null, fund=null)}, authors=[Author(id=1291338957837562663, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291338947737678621, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1291338958256993066, tenantId=1146029695717560320, journalId=1246415772164075586, articleId=1291338947737678621, authorId=1291338957837562663, language=EN, stringName=Lei WANG, firstName=Lei, middleName=null, lastName=WANG, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1a, 1b}, address=^1a.Graduate School, Guangxi University of Chinese Medicine, Nanning 530222, Guangxi Zhuang Autonomous Region, China
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汪磊（1984-），男，副教授，主要从事民族药防治慢性肝病的相关研究工作

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汪磊（1984-），男，副教授，主要从事民族药防治慢性肝病的相关研究工作

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