Article(id=1291339064771334580, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291338935477724120, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.01.022, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1727280000000, receivedDateStr=2024-09-26, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808824960, onlineDateStr=2026-08-04, pubDate=1737043200000, pubDateStr=2025-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808824960, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808824960, creator=13041195026, updateTime=1785808824960, updator=13041195026, issue=Issue{id=1291338935477724120, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='1', pageStart='1', pageEnd='148', issueExtLink='null', onlineDate='null', pubDate='1737043200000', pubDateStr='2025-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808794022, creator='13041195026', updateTime=1785808794022, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=105, endPage=110, ext={EN=ArticleExt(id=1291339065002021301, articleId=1291339064771334580, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Research status of p38 mitogen-activated protein kinases signaling pathway in osteosarcoma, columnId=1246531408630534361, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

p38 mitogen-activated protein kinases (p38 MAPK) are involved in the regulation of osteosarcoma (OS) development. Therefore, this paper reviews the current research status of p38 MAPK signaling pathway in OS, mainly including the p38 MAPK signaling pathway regulates the biological behaviors of OS such as proliferation, migration, invasion, apoptosis, autophagy, iron death, angiogenesis and epithelial-mesenchymal transition (EMT), and non-coding RNAs and oxidative stress are involved in the development of OS through the modulation of p38 MAPK signaling pathway. reviewed to provide new ideas for finding the treatment of OS.

, authors=Qing-qing QIN¹, Yi-kun WANG¹, Qing-lin YANG¹, Yong-ping WANG^{1, 2}, authorsList=Qing-qing QIN, Yi-kun WANG, Qing-lin YANG, Yong-ping WANG, authorCompany=null, correspAuthors=Yong-ping WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339065626972598, articleId=1291339064771334580, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=p38丝裂原活化蛋白激酶信号通路在骨肉瘤中的研究现状, columnId=1246531408819278046, journalTitle=中国临床药理学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

p38丝裂原活化蛋白激酶（p38 MAPK）参与调控了骨肉瘤（OS）的发生发展。本文就p38 MAPK信号通路在OS中的研究现状进行综述，主要包括p38 MAPK信号通路调控OS的增殖、迁移、侵袭、凋亡、自噬、铁死亡、血管生成和上皮-间充质转化（EMT）等生物学行为，以及非编码RNA和氧化应激通过调控p38 MAPK信号通路参与OS的发生发展进行综述，为寻找OS的治疗提供新的研究思路。

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秦庆庆（1997-），男，博士研究生，主要从事药物及分子调控骨肉瘤生物行为的相关研究

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秦庆庆（1997-），男，博士研究生，主要从事药物及分子调控骨肉瘤生物行为的相关研究

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