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The active ingredient of WINREVAIR, sotatercept-csrk, is a recombinant activin receptor IIA-Fc (ActRIIA-Fc) fusion protein that improves pro-proliferation (ActRIIA/Smad2/3-mediated) and anti-proliferation (BMPRII/Smad1/5/8-mediated) signals, thereby regulating vascular proliferation. In March 2024, WINREVAIR was approved by the U.S. Food and Drug Administration for the treatment of pulmonary arterial hypertension (PAH) in adults. Clinical studies have shown that WINREVAIR can improve exercise capacity and reduce the incidence of all-cause death or clinical worsening of PAH by 84%. Common adverse drugreactions include headache, epistaxis, rash, etc.

, authors=Yu-shan NING^1a, Tao-hua SUN^1b, An-jin CHEN^1b, Rong WEI^1c, authorsList=Yu-shan NING, Tao-hua SUN, An-jin CHEN, Rong WEI, authorCompany=null, correspAuthors=Rong WEI, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339032613613870, articleId=1291339030508073258, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=治疗肺动脉高压新药——WINREVAIR, columnId=1291339032219349293, journalTitle=中国临床药理学杂志, columnName=新药介绍, runingTitle=null, highlight=null, articleAbstract=

WINREVAIR的活性成分sotatercept-csrk是一种重组激活素受体IIA-Fc（ActRIIA-Fc）融合蛋白，可以通过改善促增殖（ActRIIA/Smad2/3介导）和抗增殖（BMPRII/Smad1/5/8介导）信号之间的平衡，从而调节血管增殖。2024年3月，WINREVAIR获美国食品和药品管理局批准，用于治疗成人肺动脉高压（PAH）。临床研究表明，WINREVAIR可提高运动能力，治疗导致全因死亡或PAH临床恶化事件的发生率降低84%。其常见药物不良反应包括头痛、鼻衄、皮疹等。

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宁宇杉（1975-），女，主管药师，主要从事医院药学相关研究

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宁宇杉（1975-），女，主管药师，主要从事医院药学相关研究

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