Article(id=1291338986501431422, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291338935477724120, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.01.015, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1717776000000, receivedDateStr=2024-06-08, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808806299, onlineDateStr=2026-08-04, pubDate=1737043200000, pubDateStr=2025-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808806299, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808806299, creator=13041195026, updateTime=1785808806299, updator=13041195026, issue=Issue{id=1291338935477724120, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='1', pageStart='1', pageEnd='148', issueExtLink='null', onlineDate='null', pubDate='1737043200000', pubDateStr='2025-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808794022, creator='13041195026', updateTime=1785808794022, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=71, endPage=75, ext={EN=ArticleExt(id=1291338988409839743, articleId=1291338986501431422, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Expression characteristics of OPG/RANKL/RANK and the relationship with fibrosis in myocardial tissues of rats with chronic heart failure, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To study the expression characteristics of osteoprotegerin (OPG)/receptor activator of nuclear factor-κB ligand (RANKL)/receptor activator of nuclear factor-κB (RANK) system and the relationship with fibrosis in myocardial tissues of rats with chronic heart failure.
Methods SD rats were randomly divided into sham-operation group (12 rats) and model group. In sham-operation group, surgical thread was passed through the abdominal aorta without constricting it after laparotomy; in model group, establish the heart failure model by abdominal aorta coarctation. The successful model rats were randomly divided into model 1 week (12 rats), model 2 weeks (11 rats), model 4 weeks (11 rats), model 8 weeks (11 rats) and model 12 weeks groups (11 rats). The end point of the study is at week 12. The contents of hydroxyproline (HYP), total myocardial collagen and collagen volume fraction (CVF) were compaired in all proups. The expression levels of OPG, RANKL and RANK proteins in cardiomyocytes were determined by Western blot.
Results The contents of HYP in sham-operation, model 1 week, model 2 weeks, model 4 weeks, model 8 weeks and model 12 weeks group were (0.25±0.04), (0.37±0.05), (0.45±0.04), (0.60±0.05), (0.82±0.10) and (1.03±0.07) μg·mg-1; the total myocardial collagen contents were (1.87±0.31), (2.73±0.38), (3.36±0.31), (4.47±0.37), (6.08±0.74) and (7.67±0.49) μg·mg-1; the CVF were (1.95±0.23)%, (2.40±0.25)%, (3.65±0.25)%, (5.43±0.29)%, (6.97±0.36)% and (9.38±0.49)%; the relative expression levels of OPG protein were 0.64±0.07, 0.80±0.07, 1.02±0.07, 1.32±0.11, 2.13±0.12 and 2.84±0.16; the relative expression levels of RANKL protein were 0.71±0.08, 1.06±0.07, 1.53±0.07, 2.62±0.12, 4.46±0.14 and 6.11±0.16; the relative expression levels of RANK protein were 0.30±0.05, 0.45±0.05, 0.63±0.06, 0.98±0.07, 1.43±0.10 and 1.63±0.10. With the extention of time, the above indexs of all model groups were significantly higher than those in the sham-operation group (all P<0.05). There were positive linear correlation between the relative expression levels of OPG, RANKL, RANK protein and the levels of CVF and total contents in cardiomyocytes of rats with chronic heart failure (all P<0.01).
Conclusions In the process of chronic heart failure, the expression of OPG/RANKL/RANK axis is obviously enhanced, in which the up-regulation of RANKL level is most obvious. The expression level of OPG/RANKL/RANK is positively correlated with CVF and total myocardial collagen content.
, authors=Xin YANG
1a, Xue-kun CAI
1a, Ze-long WU
1a, An-tao CHEN
2, Zi-hao CHEN
2, Xuan XIE
2, Jia-kang OU
2, Zhao-qi HUANG
1b, authorsList=Xin YANG, Xue-kun CAI, Ze-long WU, An-tao CHEN, Zi-hao CHEN, Xuan XIE, Jia-kang OU, Zhao-qi HUANG, authorCompany=null, correspAuthors=Zhao-qi HUANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291338989240311936, articleId=1291338986501431422, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=OPG/RANKL/RANK在慢性心力衰竭大鼠心肌中的表达特征及其与心肌纤维化的关系, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 研究骨保护素（OPG）/核因子κB受体活化因子配体（RANKL）/核因子κB受体活化因子（RANK）在慢性心力衰竭大鼠心肌中的表达特点，及其与心肌纤维化的关系。
方法 将SD大鼠随机分成假手术组（12只）和模型组。假手术组开腹后仅将手术丝线穿过腹主动脉，不缩窄腹主动脉；模型组用腹主动脉缩窄法复制慢性心力衰竭模型，并将造模成功的大鼠根据不同的观察时间随机分为模型1、2、4、8、12周组，分别有12、11、11、11、11只。实验终点为12周。比较各组大鼠心肌细胞中羟脯氨酸（HYP）、心肌胶原总含量及胶原容积分数（CVF），用蛋白质印迹法检测心肌细胞中OPG、RANKL和RANK蛋白的表达水平。
结果 假手术组和模型1、2、4、8、12周组心肌细胞中HYP含量分别为（0.25±0.04）、（0.37±0.05）、（0.45±0.04）、（0.60±0.05）、（0.82±0.10）和（1.03±0.07）μg·mg-1，心肌胶原总含量分别为（1.87±0.31）、（2.73±0.38）、（3.36±0.31）、（4.47±0.37）、（6.08±0.74）和（7.67±0.49）μg·mg-1，CVF分别为（1.95±0.23）%、（2.40±0.25）%、（3.65±0.25）%、（5.43±0.29）%、（6.97±0.36）%和（9.38±0.49）%，OPG蛋白相对表达水平分别为0.64±0.07、0.80±0.07、1.02±0.07、1.32±0.11、2.13±0.12和2.84±0.16，RANKL蛋白相对表达水平分别为0.71±0.08、1.06±0.07、1.53±0.07、2.62±0.12、4.46±0.14和6.11±0.16，RANK蛋白相对表达水平分别为0.30±0.05、0.45±0.05、0.63±0.06、0.98±0.07、1.43±0.10和1.63±0.10。随着时间的延长，模型组与假手术组相比，上述指标均显著升高，在统计学上差异均有统计学意义（均P<0.05）。慢性心力衰竭大鼠心肌细胞中OPG、RANK、RANKL蛋白相对表达水平与CVF、心肌胶原总含量均呈显著正相关（均P<0.01）。
结论 在慢性心力衰竭过程中，OPG/RANKL/RANK轴表达明显增强，其中以RANKL增强最为明显，且OPG/RANKL/RANK表达水平与CVF、心肌胶原总含量均呈显著正相关。
, authors=杨薪
1a, 蔡学坤
1a, 吴泽龙
1a, 陈安涛
2, 陈子豪
2, 谢轩
2, 区嘉康
2, 黄兆琦
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杨薪（1977-），女，副主任医师，主要从事老年冠心病、心力衰竭等方面的相关研究
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