Article(id=1291339036891803991, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291338935477724120, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.01.014, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1723392000000, receivedDateStr=2024-08-12, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808818313, onlineDateStr=2026-08-04, pubDate=1737043200000, pubDateStr=2025-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808818313, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808818313, creator=13041195026, updateTime=1785808818313, updator=13041195026, issue=Issue{id=1291338935477724120, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='1', pageStart='1', pageEnd='148', issueExtLink='null', onlineDate='null', pubDate='1737043200000', pubDateStr='2025-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808794022, creator='13041195026', updateTime=1785808794022, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=65, endPage=70, ext={EN=ArticleExt(id=1291339037105713496, articleId=1291339036891803991, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Regulation of NRF2/PINK1 pathway by rutaecarpine on airway epithelial barrier repair in chronic obstructive pulmonary disease rats, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective Based on nuclear factor E2 associated factor 2 (NRF2) /PTEN induced hypothesized kinase 1 (PINK1) pathway, explored the ameliorating effect of rutaecarpine on chronic obstructive pulmonary disease (COPD) rats and its repairing effect on airway epithelial barrier.
Methods COPD rat model were established by smoke combined with airway infusion of lipopolysaccharide; and were randomly divided into model group, control group, and experimental -L group, experimental -M group, experimental-H group, 10 rats per group. Another 10 normal rats were selected as the normal group. Experimental -L, -M, -H groups were intraperitoneally injected 15, 30 and 60 mg·mL-1 rutaecarpine at the dose of 10 mL·kg-1, respectively. The control group was received 4.05×10-2 mg·mL-1 prednisone acetate at the dose of 10 mL·kg-1 by gavage. The normal and model groups were given 0.9% NaCl by intraperitoneal injection. Six groups were treated for 28 days with once a day. The first second forced expiratory volume (FEV1) and forced vital capacity (FVC) of rats were measured by minor animal lung function tester. The levels of interleukin (IL) and interferon-γ (INF-γ) in alveolar lavage fluid were determined by enzyme-linked immunosorbent assay method. The expression levels of PINK1 and NRF2 proteins in the lung tissue were determined by Western blot.
Results The levels of FEV1 in the experimental -M group, experimental -H group, control group, model group and normal group were (5.17±0.16), (6.36±0.12), (5.06±0.07), (2.24±0.20) and (6.84±0.11) mL; the levels of FVC were (6.71±0.13), (7.56±0.12), (6.81±0.07), (4.46±0.14) and (7.92±0.11) mL; the levels of IL-12 in alveolar lavage fluid were (7.08±0.51), (9.03±0.54), (7.92±0.79), (3.61±1.01) and (10.15±0.82) pg·mL-1; the levels of IL-9 in alveolar lavage fluid were (22.49±2.27), (15.02±1.41), (17.47±1.84), (38.72±1.28) and (11.78±0.94) pg·mL-1; the levels of INF-γ in alveolar lavage fluid were (13.18±0.54), (16.25±0.60), (15.23±0.43), (6.97±0.89) and (17.22±1.15) pg·mL-1; the relative expression levels of PINK1 protein were 1.10±0.06, 1.30±0.09, 1.18±0.15, 0.42±0.03 and 1.61±0.05; the relative expression levels of NRF2 protein were 0.91±0.05, 1.46±0.03, 1.35±0.07, 0.53±0.07 and 1.64±0.11, respectively. The differences of above indexes were statistically significant between the experimental -M group, experimental -H group, control group and the model group (all P<0.05).
Conclusion Rutaecarpine can inhibit inflammation, improve lung function and repair airway epithelial barrier in COPD rats, and its mechanism may be related to regulating NRF2/PINK1 pathway.
, authors=Song ZHANG, Bo HONG, Ling CHEN, Shen-da CHEN, authorsList=Song ZHANG, Bo HONG, Ling CHEN, Shen-da CHEN, authorCompany=null, correspAuthors=Bo HONG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339037609029977, articleId=1291339036891803991, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=吴茱萸次碱调节NRF2/PINK1通路对慢性阻塞性肺疾病大鼠气道上皮屏障修复作用的研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 基于核因子E2相关因子2（NRF2）/PTEN诱导假定激酶1（PINK1）通路探索吴茱萸次碱对慢性阻塞性肺疾病（COPD）大鼠的改善作用，及其对气道上皮屏障的修复作用。
方法 用烟熏联合气道滴注脂多糖的方法构建COPD大鼠模型，并随机分为模型组、对照组和低、中、高剂量实验组，每组10只；另取10只正常大鼠作为正常组。低、中、高剂量实验组按10 mL·kg-1的剂量分别腹腔注射15、30、60 mg·mL-1的吴茱萸次碱；对照组按10 mL·kg-1的剂量灌胃给予4.05×10-2 mg·mL-1的醋酸泼尼松；正常组和模型组均腹腔注射等量0.9% NaCl。6组大鼠每天给药1次，连续给药28 d。用小动物肺功能测定仪测定大鼠的第1秒用力呼气容积（FEV1）和用力肺活量（FVC），用酶联免疫吸附试验法测定肺泡灌洗液中白细胞介素（IL）和干扰素-γ（INF-γ）的水平，用蛋白质印迹法测定肺组织中PINK1和NRF2蛋白的表达水平。
结果 中、高剂量实验组和对照组、模型组、正常组的FEV1分别为（5.17±0.16）、（6.36±0.12）、（5.06±0.07）、（2.24±0.20）和（6.84±0.11）mL，FVC分别为（6.71±0.13）、（7.56±0.12）、（6.81±0.07）、（4.46±0.14）和（7.92±0.11）mL，肺泡灌洗液中IL-12水平分别为（7.08±0.51）、（9.03±0.54）、（7.92±0.79）、（3.61±1.01）和（10.15±0.82）pg·mL-1，肺泡灌洗液中IL-9水平分别为（22.49±2.27）、（15.02±1.41）、（17.47±1.84）、（38.72±1.28）和（11.78±0.94）pg·mL-1，肺泡灌洗液中INF-γ水平分别为（13.18±0.54）、（16.25±0.60）、（15.23±0.43）、（6.97±0.89）和（17.22±1.15）pg·mL-1，PINK1蛋白相对表达水平分别为1.10±0.06、1.30±0.09、1.18±0.15、0.42±0.03和1.61±0.05，NRF2蛋白相对表达水平分别为0.91±0.05、1.46±0.03、1.35±0.07、0.53±0.07和1.64±0.11。中、高剂量实验组和对照组的上述指标与模型组相比，在统计学上差异均有统计学意义（均P<0.05）。
结论 吴茱萸次碱能够抑制COPD大鼠的炎症反应，改善COPD大鼠的肺功能，修复COPD大鼠的气道上皮屏障，其机制可能与调节NRF2/PINK1通路有关。
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张松（1980-），男，副主任医师，主要从事慢性气道疾病的临床诊疗工作
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