Article(id=1291338993921160184, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291338935477724120, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.01.008, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1721836800000, receivedDateStr=2024-07-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808808068, onlineDateStr=2026-08-04, pubDate=1737043200000, pubDateStr=2025-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808808068, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808808068, creator=13041195026, updateTime=1785808808068, updator=13041195026, issue=Issue{id=1291338935477724120, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='1', pageStart='1', pageEnd='148', issueExtLink='null', onlineDate='null', pubDate='1737043200000', pubDateStr='2025-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808794022, creator='13041195026', updateTime=1785808794022, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=36, endPage=39, ext={EN=ArticleExt(id=1291338994399310841, articleId=1291338993921160184, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of esketamine combined with midazolam in elderly patients undergoing hip replacement, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To investigate the effect of subanesthetic dose esketamine hydrochloride injection combined with midazolam injection on hip replacement in elderly patients.
Methods The elderly patients undergoing hip replacement were divided into control group and treatment group. The control group was given 0.02 mg·kg-1 midazolam injection; the treatment group was given 0.02 mg·kg-1 midazolam injection combined with 0.25 mg·kg-1 esketamine hydrochloride injection. Anesthesia (sedation, analgesic effect), hemodynamic indexes, and safety evaluation.
Results There were 90 cases in the treatment group and 90 cases in the control group. The scores of sedation in the treatment group and the control group were (1.54±0.28) and (1.67±0.35) points, respectively; the scores of pain simulation at 2 h after operation were (3.16±0.47) and (3.38±0.59) points, respectively; at the end of the operation, the mean arterial pressure of the treatment group and the control group were (83.06±2.47) and (82.15±2.94) mmHg, respectively; the heart rate were (82.04±3.25) and (80.75±3.32) time·min-1, respectively, and the difference was statistically significant (all P<0.05). The total incidence of adverse drug reactions in the treatment group and the control group was 8.89% (8 cases /90 cases) and 13.33% (12 cases /90 cases), respectively, with no statistical significance (P>0.05).
Conclusion The subanesthetic dose of esketamine hydrochloride injection combined with midazolam hydrochloride injection can effectively stabilize the hemodynamic level of the body and reduce postoperative pain in elderly patients with hip replacement with good safety.
, authors=Hao WANG, Qing-qing LIU, authorsList=Hao WANG, Qing-qing LIU, authorCompany=null, correspAuthors=Hao WANG, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291338995535967226, articleId=1291338993921160184, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=艾司氯胺酮联合咪达唑仑用于老年髋关节置换术患者的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探讨亚麻醉剂量盐酸艾司氯胺酮注射液联合咪达唑仑注射液对老年髋关节置换术的影响。
方法 将拟行髋关节置换术的老年患者随机分为对照组和试验组。对照组静脉注射0.02 mg·kg-1咪达唑仑注射液；试验组静脉注射0.02 mg·kg-1咪达唑仑注射液联合0.25 mg·kg-1盐酸艾司氯胺酮注射液。记录2组患者的麻醉情况（镇静、镇痛效果）、血流动力学指标，并进行安全性评价。
结果 试验组入组90例，对照组入组90例。试验组和对照组的术中镇静效果评分分别为（1.54±0.28）和（1.67±0.35）分，术后2 h疼痛模拟评分分别为（3.16±0.47）和（3.38±0.59）分；手术结束时，试验组和对照组的平均动脉压分别为（83.06±2.47）和（82.15±2.94）mmHg，心率分别为（82.04±3.25）和（80.75±3.32）time·min-1，在统计学上差异均有统计学意义（均P<0.05）。试验组和对照组的药物不良反应总发生率分别为8.89%（8例/90例）和13.33%（12例/90例），在统计学上差异无统计学意义（P>0.05）。
结论 老年髋关节置换术患者应用亚麻醉剂量盐酸艾司氯胺酮注射液联合咪达唑仑注射液可有效稳定机体血流动力学水平，减轻患者术后疼痛，安全性良好。
, authors=王昊, 刘晴晴, authorsList=王昊, 刘晴晴, authorCompany=null, correspAuthors=王昊, authorNote=
王昊（1990-），女，主治医师，主要从事临床麻醉方面的工作
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