Article(id=1291339010526404889, tenantId=1146029695717560320, journalId=1246415772164075586, issueId=1291338935477724120, articleNumber=null, orderNo=null, doi=10.13699/j.cnki.1001-6821.2025.01.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1721836800000, receivedDateStr=2024-07-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1785808812027, onlineDateStr=2026-08-04, pubDate=1737043200000, pubDateStr=2025-01-17, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1785808812027, onlineIssueDateStr=2026-08-04, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1785808812027, creator=13041195026, updateTime=1785808812027, updator=13041195026, issue=Issue{id=1291338935477724120, tenantId=1146029695717560320, journalId=1246415772164075586, year='2025', volume='41', issue='1', pageStart='1', pageEnd='148', issueExtLink='null', onlineDate='null', pubDate='1737043200000', pubDateStr='2025-01-17', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1785808794022, creator='13041195026', updateTime=1785808794022, updator='13041195026', preIssue=null, nextIssue=null, articleTotal=null, ext=null, issueFiles=null, downloadFileDto=null}, startPage=11, endPage=15, ext={EN=ArticleExt(id=1291339010954223898, articleId=1291339010526404889, tenantId=1146029695717560320, journalId=1246415772164075586, language=EN, title=Clinical trial of cardiovascular protective effect of dapagliflozin on patients with HFpEF complicated with T2DM, columnId=1246531407326105792, journalTitle=Chinese Journal of Clinical Pharmacology, columnName=Clinical and Basic Bridging Research, runingTitle=null, highlight=null, articleAbstract=
Objective To explore the cardiovascular protective effect of dapagliflozin on patients with heart failure with preserved ejection fraction (HFpEF) complicated with type 2 diabetes mellitus (T2DM).
Methods Patients with HFpEF complicated with T2DM were divided into treatment group and control group according to cohort method. The control group was given 0.5 g of metformin hydrochloride tablet orally twice a day, while the treatment group was given 10 mg of dapagliflozin tablet orally once a day on the basis of treatment in the control group. Patients in both groups were continuously treated for 6 months. The clinical efficacy after treatment and blood glucose indicators [fasting blood glucose (FBG), 2 hours postprandial blood glucose (2 h PBG), glycosylated hemoglobin (HbA1c)], echocardiographic left ventricular parameters [left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), left ventricular remodeling index (LVRI), left ventricular mass index (LVMI)] and serum N-terminal pro-brain natriuretic peptide (NT-proBNP), serum myocardial fibrosis indicators [matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1)] before and after treatment were compared between both groups, and the safety evaluation was performed.
Results Seventy-five cases in treatment group and 72 cases in control group were included. After treatment, the total effective rates in treatment group and control group were 93.33% (70 cases/75 cases) and 81.94% (59 cases/72 cases), respectively (P<0.05). After treatment, the levels of FBG, 2 h PBG, HbA1c, LVEF and LVEDD revealed no statistical differences between treatment group and control group (all P>0.05). After treatment, LVRI values in treatment group and control group were (2.17±0.41) and (2.54±0.46) g·mL-2; LAMI values were (102.47±10.32) and (113.84±15.52) g·m-2; serum NT-proBNP levels were (652.38±208.26) and (993.24±302.69) pg·mL-1; MMP-9 levels were (142.52±21.67) and (168.73±25.88) mg·L-1; TIMP-1 levels were (3.68±0.84) and (3.12±0.91) μg·L-1, respectively (all P<0.05). The total incidence rates of adverse reactions in treatment group and control group were 14.67% (11 cases/75 cases) and 12.50% (9 cases/72 cases), respectively (P>0.05).
Conclusion Dapagliflozin can improve ventricular remodeling and enhance cardiac function in patients with HFpEF complicated with T2DM, and it has a significant cardiovascular protective effect.
, authors=Zuo-ling LIU, Yun LING, Ling-yan FANG, authorsList=Zuo-ling LIU, Yun LING, Ling-yan FANG, authorCompany=null, correspAuthors=Zuo-ling LIU, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1291339011465928987, articleId=1291339010526404889, tenantId=1146029695717560320, journalId=1246415772164075586, language=CN, title=达格列净对HFpEF合并T2DM患者心血管保护作用的临床研究, columnId=1246531407485489349, journalTitle=中国临床药理学杂志, columnName=临床与基础桥接研究, runingTitle=null, highlight=null, articleAbstract=
目的 探究达格列净对射血分数保留的心力衰竭（HFpEF）合并2型糖尿病（T2DM）患者的心血管保护作用。
方法 将HFpEF合并T2DM患者按照队列法分为试验组和对照组。对照组给予盐酸二甲双胍片每次0.5 g，bid，口服；试验组在对照组治疗的基础上，给予达格列净片每次10 mg，qd，口服。2组患者均持续用药6个月。比较2组患者的临床疗效，比较2组患者治疗前后血糖指标[空腹血糖（FBG）、餐后2 h血糖（2 h PBG）、糖化血红蛋白（HbA1c）]、超声心动图左心参数[射血分数（LVEF）、左室舒张末内径（LVEDD）、左心室重构指数（LVRI）、左心室质量指数（LVMI）]及血清N末端脑钠肽前体（NT-proBNP）、血清心肌纤维化指标[基质金属蛋白酶-9（MMP-9）、基质金属蛋白酶组织抑制因子-1（TIMP-1）]的变化，进行安全性评价。
结果 试验组与对照组分别入组75例和72例。治疗后，试验组和对照组总有效率分别为93.33%（70例/75例）和81.94%（59例/72例），在统计学上差异有统计学意义（P<0.05）。治疗后，试验组和对照组患者的FBG、2 h PBG、HbA1c、LVEF、LVEDD比较，在统计学上差异均无统计学意义（均P>0.05）。治疗后，试验组和对照组患者的LVRI分别为（2.17±0.41）和（2.54±0.46）g·mL-2，LVMI分别为（102.47±10.32）和（113.84±15.52）g·m-2，血清NT-proBNP水平分别为（652.38±208.26）和（993.24±302.69）pg·mL-1，MMP-9水平分别为（142.52±21.67）和（168.73±25.88）mg·L-1，TIMP-1水平分别为（3.68±0.84）和（3.12±0.91）μg·L-1，在统计学上差异均有统计学意义（均P<0.05）。试验组和对照组的药物不良反应总发生率分别为14.67%（11例/75例）和12.50%（9例/72例），在统计学上差异无统计学意义（P>0.05）。
结论 达格列净治疗HFpEF合并T2DM患者，可改善患者心室重构、提高心功能，具有显著心血管保护作用。
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刘左玲（1982-），女，主任医师，主要从事心力衰竭方面的临床诊疗工作
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