Article(id=1286995082989507375, tenantId=1146029695717560320, journalId=1285991164901855263, issueId=1286995055894315111, articleNumber=null, orderNo=null, doi=10.3969/j.issn.1001-1242.2026.07.003, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1719244800000, receivedDateStr=2024-06-25, revisedDate=null, revisedDateStr=null, acceptedDate=null, acceptedDateStr=null, onlineDate=1784773138996, onlineDateStr=2026-07-23, pubDate=1784044800000, pubDateStr=2026-07-15, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1784773138996, onlineIssueDateStr=2026-07-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1784773138996, creator=13701087609, updateTime=1784773138996, updator=13701087609, issue=Issue{id=1286995055894315111, tenantId=1146029695717560320, journalId=1285991164901855263, year='2026', volume='41', issue='7', pageStart='1009', pageEnd='1183', issueExtLink='null', onlineDate='null', pubDate='1784044800000', pubDateStr='2026-07-15', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=1, specialIssue=null, createTime=1784773132536, creator='13701087609', updateTime=1784773687037, updator='13701087609', preIssue=null, nextIssue=null, articleTotal=null, ext={EN=IssueExt(id=1286997381702979733, tenantId=1146029695717560320, journalId=1285991164901855263, issueId=1286995055894315111, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1286997381702979734, tenantId=1146029695717560320, journalId=1285991164901855263, issueId=1286995055894315111, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null, downloadFileDto=null}, startPage=1028, endPage=1036, ext={EN=ArticleExt(id=1286995083144696624, articleId=1286995082989507375, tenantId=1146029695717560320, journalId=1285991164901855263, language=EN, title=The protective effects of treadmill exercise training on lung injury following spinal cord injury, columnId=null, journalTitle=Chinese Journal of Rehabilitation Medicine, columnName=null, runingTitle=null, highlight=null, articleAbstract=
Objective:

To investigate the protective effects of treadmill exercise training on lung injury following spinal cord injury (SCI) and its potential underlying mechanisms.

Method:

A rat model of SCI was established and randomly divided into different intervention groups. The experimental group underwent treadmill exercise training, while the control group received no exercise intervention. Lung tissue was analyzed for the expression of inflammatory factors TNF-α and IL-6, the activity of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway, and the level of autophagy. These measures were used to assess the impact of exercise training on lung injury post-SCI.

Result:

Compared to the control group, treadmill exercise training significantly reduced the expression of inflammatory factors in the lungs post-SCI, activated the PI3K/AKT/mTOR signaling pathway, and promoted lung autophagy in lung tissue.

Conclusion:

Treadmill exercise training can mitigate lung injury after SCI by activating the PI3K/AKT/mTOR signaling pathway and promoting autophagy in lung tissue.

, authors=Xiao PAN1, Xianglian YANG1, Xianbin WANG1, authorsList=Xiao PAN, Xianglian YANG, Xianbin WANG, authorCompany=null, correspAuthors=null, authorNote=null, correspAuthorsNote=null, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, fund=null), CN=ArticleExt(id=1286995083417326386, articleId=1286995082989507375, tenantId=1146029695717560320, journalId=1285991164901855263, language=CN, title=跑台运动训练对脊髓损伤后大鼠肺功能的影响, columnId=1286995083228582705, journalTitle=中国康复医学杂志, columnName=基础研究, runingTitle=null, highlight=null, articleAbstract=
目的:

研究跑台运动训练对脊髓损伤(spinal cord injury, SCI)后肺损伤的保护作用及其潜在机制。

方法:

本研究通过建立SCI大鼠模型,分组进行不同干预处理。实验组大鼠接受跑台运动训练,对照组大鼠则未进行运动干预。通过检测肺组织中炎症因子TNF-α,IL-6的表达、PI3K/AKT/mTOR信号通路的表达及肺部自噬水平,评估运动训练对SCI后肺损伤的影响。

结果:

与对照组相比,跑台运动训练显著降低了SCI后肺部炎症因子的表达,激活了PI3K/AKT/mTOR信号通路,并促进了肺部自噬。

结论:

跑台运动训练通过激活PI3K/AKT/mTOR信号通路并促进肺部自噬减轻SCI后的肺损伤。

, authors=潘晓1, 杨香莲1, 王先斌1, 陈彦1, 胡寿星2, 孙思杰2, 吴霜1, 2, 3, authorsList=潘晓, 杨香莲, 王先斌, 陈彦, 胡寿星, 孙思杰, 吴霜, authorCompany=null, correspAuthors=吴霜, authorNote=

潘晓,女,硕士研究生,住院医师;

, correspAuthorsNote=
3
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潘晓,女,硕士研究生,住院医师;

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跑台运动训练对脊髓损伤后大鼠肺功能的影响
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潘晓 1 , 杨香莲 1 , 王先斌 1 , 陈彦 1 , 胡寿星 2 , 孙思杰 2 , 吴霜 1, 2, 3
中国康复医学杂志 | 基础研究 2026,41(7): 1028-1036
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中国康复医学杂志 |基础研究 2026 , 41 (7) : 1028 -1036
跑台运动训练对脊髓损伤后大鼠肺功能的影响
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潘晓1, 杨香莲1, 王先斌1, 陈彦1, 胡寿星2, 孙思杰2, 吴霜1, 2, 3
作者信息
  • 1贵州医科大学附属医院康复医学科,贵州省 贵阳市,550001
  • 2贵州医科大学,贵州省 贵阳市,550001
通讯作者:
3
作者简介:

潘晓,女,硕士研究生,住院医师;

The protective effects of treadmill exercise training on lung injury following spinal cord injury
Xiao PAN1, Xianglian YANG1, Xianbin WANG1
Affiliations
  • The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, 550001
出版时间: 2026-07-15 doi: 10.3969/j.issn.1001-1242.2026.07.003
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目的:

研究跑台运动训练对脊髓损伤(spinal cord injury, SCI)后肺损伤的保护作用及其潜在机制。

方法:

本研究通过建立SCI大鼠模型,分组进行不同干预处理。实验组大鼠接受跑台运动训练,对照组大鼠则未进行运动干预。通过检测肺组织中炎症因子TNF-α,IL-6的表达、PI3K/AKT/mTOR信号通路的表达及肺部自噬水平,评估运动训练对SCI后肺损伤的影响。

结果:

与对照组相比,跑台运动训练显著降低了SCI后肺部炎症因子的表达,激活了PI3K/AKT/mTOR信号通路,并促进了肺部自噬。

结论:

跑台运动训练通过激活PI3K/AKT/mTOR信号通路并促进肺部自噬减轻SCI后的肺损伤。

脊髓损伤  /  肺损伤  /  跑台运动训练  /  自噬  /  PI3K/AKT/mTOR信号通路
Objective:

To investigate the protective effects of treadmill exercise training on lung injury following spinal cord injury (SCI) and its potential underlying mechanisms.

Method:

A rat model of SCI was established and randomly divided into different intervention groups. The experimental group underwent treadmill exercise training, while the control group received no exercise intervention. Lung tissue was analyzed for the expression of inflammatory factors TNF-α and IL-6, the activity of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway, and the level of autophagy. These measures were used to assess the impact of exercise training on lung injury post-SCI.

Result:

Compared to the control group, treadmill exercise training significantly reduced the expression of inflammatory factors in the lungs post-SCI, activated the PI3K/AKT/mTOR signaling pathway, and promoted lung autophagy in lung tissue.

Conclusion:

Treadmill exercise training can mitigate lung injury after SCI by activating the PI3K/AKT/mTOR signaling pathway and promoting autophagy in lung tissue.

spinal cord injury  /  lung injury  /  treadmill exercise training  /  autophagy  /  PI3K/AKT/mTOR signaling pathway
潘晓, 杨香莲, 王先斌, 陈彦, 胡寿星, 孙思杰, 吴霜. 跑台运动训练对脊髓损伤后大鼠肺功能的影响. 中国康复医学杂志, 2026 , 41 (7) : 1028 -1036 . DOI: 10.3969/j.issn.1001-1242.2026.07.003
Xiao PAN, Xianglian YANG, Xianbin WANG. The protective effects of treadmill exercise training on lung injury following spinal cord injury[J]. Chinese Journal of Rehabilitation Medicine, 2026 , 41 (7) : 1028 -1036 . DOI: 10.3969/j.issn.1001-1242.2026.07.003
  • 国家自然科学基金委员会地区项目(82060419; 82260452)
  • 贵州省科学技术基金项目(黔科合基础-ZK[2022]重点045)
  • 贵州省科学技术基金项目(黔科合基础-ZK[2022]一般438)
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2026年第41卷第7期
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文章信息
doi: 10.3969/j.issn.1001-1242.2026.07.003
  • 接收时间:2024-06-25
  • 首发时间:2026-07-23
  • 出版时间:2026-07-15
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  • 收稿日期:2024-06-25
基金
国家自然科学基金委员会地区项目(82060419; 82260452)
贵州省科学技术基金项目(黔科合基础-ZK[2022]重点045)
贵州省科学技术基金项目(黔科合基础-ZK[2022]一般438)
作者信息
    1贵州医科大学附属医院康复医学科,贵州省 贵阳市,550001
    2贵州医科大学,贵州省 贵阳市,550001

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3
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2种不同金属材料的力学参数

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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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