Home Journals Articles Updates About
CN
image
收藏切换
Research advances in the impact of nitric oxide on the blood-brain barrier
收藏切换
PDF
Jingyi XIN1, 2, 3, Meiwen YANG1, 2, 4, Fenfang HONG5, *, Shulong YANG1, 2, 3, *
Chinese Journal of Comparative Medicine | 2026, 36(6) : 122 - 133
Less
收藏切换
Chinese Journal of Comparative Medicine | 2026, 36(6): 122-133
• Research Progress •
Research advances in the impact of nitric oxide on the blood-brain barrier
Full
Jingyi XIN1, 2, 3, Meiwen YANG1, 2, 4, Fenfang HONG5, *, Shulong YANG1, 2, 3, *
Affiliations
  • 1.Key Research Laboratory of Chronic Disease, Fuzhou Medical College of Nanchang University, Fuzhou 344100, China
  • 2.Technology Innovation Center of Chronic Disease Research in Fuzhou City, Fuzhou Science and Technology Bureau, Fuzhou 344100
  • 3.Department of Physiology, Fuzhou Medical College of Nanchang University, Fuzhou 344100
  • 4.Department of Surgery, Fuzhou Medical College of Nanchang University, Fuzhou 344100
  • 5.Experimental Center of Pathogen Biology, Basic College of Medicine, Nanchang University, Nanchang 330031
Published: 2026-03-30 doi: 10.3969/j.issn.1671-7856.2026.06.012
Outline
收藏切换

The blood-brain barrier (BBB) plays a critical role in maintaining brain homeostasis. BBB dysfunction is closely associated with various neurodegenerative diseases and acute brain injuries, which impair brain defense mechanisms and can exacerbate the progression of pathological conditions. Nitric oxide (NO), an important biological signaling molecule, exerts a wide range of effects on the central nervous system, influencing both physiological and pathological states. This review summarizes the production and metabolism of NO and their effects on BBB permeability, followed by an introduction to the role of NO in pathological conditions such as cerebral ischemia-reperfusion injury, neurodegenerative diseases, and brain tumors. NO regulates BBB integrity through the regulation of tight junction proteins and vascular endothelial growth factor receptor 2 (VEGFR2). The review also delves into the potential of NO as a therapeutic target in drug delivery and gene therapy, and explores its potential to enhance drug penetration across the BBB. These explorations provide novel perspectives for future therapeutic strategies.

blood-brain barrier  /  nitric oxide synthase  /  endothelial cells  /  tight junction proteins
Jingyi XIN, Meiwen YANG, Fenfang HONG, Shulong YANG. Research advances in the impact of nitric oxide on the blood-brain barrier[J]. Chinese Journal of Comparative Medicine, 2026 , 36 (6) : 122 -133 . DOI: 10.3969/j.issn.1671-7856.2026.06.012
Appendix
Less
Year 2026 volume 36 Issue 6
PDF
105
24
Cite this Article
BibTeX
Article Info
doi: 10.3969/j.issn.1671-7856.2026.06.012
  • Receive Date：2025-08-31
  • Online Date：2026-08-05
  • Published：2026-03-30
Article Data
Affiliations
History
  • Received：2025-08-31
Funding
Affiliations
    1.Key Research Laboratory of Chronic Disease, Fuzhou Medical College of Nanchang University, Fuzhou 344100, China
    2.Technology Innovation Center of Chronic Disease Research in Fuzhou City, Fuzhou Science and Technology Bureau, Fuzhou 344100
    3.Department of Physiology, Fuzhou Medical College of Nanchang University, Fuzhou 344100
    4.Department of Surgery, Fuzhou Medical College of Nanchang University, Fuzhou 344100
    5.Experimental Center of Pathogen Biology, Basic College of Medicine, Nanchang University, Nanchang 330031
References
Share
https://castjournals.cast.org.cn/joweb/zgbjyxzz/EN/10.3969/j.issn.1671-7856.2026.06.012
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House