To enhance the importance of buildings and bridges as physical hazard-bearing bodies for hazardous chemical accidents in regional risk assessment. In this paper, a physical vulnerability assessment model was established, and a risk assessment method was proposed, which considered the hazardous chemical accident consequences and the physical vulnerability of hazard-bearing bodies. Firstly, areal locations of hazardous atmospheres (ALOHA) was used to simulate the possible risk footprints of hazards. Secondly, a physical vulnerability assessment model including exposure, sensitivity and adaptability was established. Density of structures and distance from the accident center supply were selected as the exposure dimension layer. The age of the structures, building height, seismic grade of building and bridge length were selected as sensitivity dimension layer. Emergency shelter area, road area and infrastructure maintenance funds were selected as the adaptability index layer, and the driving force factors of physical hazard-bearing body vulnerability were analyzed through the geographical detector. Finally, arc geographic information system (ArcGIS) was used to superimpose the accident consequence map and the physical vulnerability map to generate a comprehensive risk map to realize the comprehensive risk visualization of hazard-bearing body. This method was applied to the risk assessment of physical hazard-bearing bodies in a town of Tianjin. The results show that the density of structures and the distance from the accident center have the strongest explanatory power for the vulnerability of physical hazard-bearing bodies. The explanatory power of these two factors is 0.515 and 0.464, respectively. High-risk areas result from the spatial overlap of high hazard and high vulnerability. The comprehensive regional risk resulting from the combination of accident consequences and vulnerability exhibits significant spatial variation. On the accident consequence map, the eastern part of the town near the hazard release point is the most dangerous area. However, owing to the low vulnerability of disaster-bearing bodies in the surrounding area of the release point, it is classified as a medium-risk zone on the comprehensive risk map.