In order to further improve the safety risk control capability of chemical research and experimental equipment，the causes of chemical research and experiment safety accidents in recent years were analyzed. Based on the current management practice of chemical research and experimental equipment，the safety risk control throughout the full life cycle from various aspects was implemented，such as feasibility study，design，construction，trial operation，and scrapping. The focus was on exploring the three main aspects of early safety review，equipment design，construction management，and operation safety management. By comparing the risk control of relatively mature hazardous chemical construction projects，the weak links and prominent problems in the chemical research and experimental equipment were analyzed. The results indicate that the safety risk control of chemical research and experiments is a systematic project that should fully draw on the experience of safety risk control in hazardous chemical construction projects. Scientific research and experimental equipment should be classified and reviewed for safety access control. Through source safety review，specification management design，construction quality control，confirmation of safety conditions during operation，equipment and facility management，hazardous chemical management，and other full process risk control measures，safety risks can be minimized to the greatest extent，providing references and choices for risk management of scientific research and experimental equipment.