To study the key points of process safety management in chemical infrastructure projects and carry out targeted safety management，the safety inspection of a gasification unit during construction in a chemical project of an energy group was studied. The entire process safety records of the project were collected，classified，organized，statistically analyzed，compared，and inspected. The key and difficult points of project safety management were summarized by comparing the types and quantities of safety hazards in each unit，the number of hazards per contract valuing million yuan，the distribution of various types of safety hazards，the distribution of safety hazards in each unit，and the comparison of safety hazards in similar units. The research shows that safety protection is the type of safety hazards that generate the most hazards during project construction，and reducing the number of such safety protection hazards can effectively improve the level of project safety management. The safety management level of each construction unit varies，and each construction unit has its own management characteristics. The list of qualified contractors should be further improved through contractor evaluation. It is also necessary to establish a qualified contractor database and record the advantages and disadvantages of contractor safety management，so as to facilitate targeted safety management in future projects.