In the application process of blockchain technology，insufficient attention has been paid to the research on safety barriers that are more suitable for preventing complex system safety problems. To solve this problem，firstly，the safety requirements of blockchain itself and the support of safety barrier theory were introduced，which was combined with the security application of blockchain technology in the industrial field. Then，the main safety barrier models within qualitative and quantitative perspectives were summarized，so were the progress of security analysis model of software system and of performance evaluation of safety barrier. Then，the research status of safety precautions related to security risks of blockchain technology was summarized. Finally，in accordance with the trend of coupling coordination in safety barrier models，a research framework of safety barrier models related to the application of blockchain technology was put forward，which was based on the research progress of quantitative methods studying complex system coupling coordination and complex causal mechanism. It was a framework system including safety analysis，situational construction，system modeling，mechanism analysis，effect assessment and implementation path. The results show that the research on the safety barrier models related to blockchain technology should cover static series diagram pattern with Bow-Tie model as core and ARAMIS(Accidental Risk Assessment Methodology for Industries System) and coupling perspective STAMP (Systems Theoretic Accident Model and Processes) models as integrators，dynamic evolution mechanism research that includes dynamic Bayesian network analysis by transforming the static models into BN，and the effect assessment of safety barrier system. The study on coupling coordination and nonlinear causal analysis focusing on entropy deepen this coupling integration research system.