In order to enhance maritime emergency rescue efficiency and reduce casualties, a systematic safety design strategy for maritime casualty disposal cabins was proposed. CTA was first used to identify rescue personnel's core needs during critical tasks. The Kawakita Jiro Method method and Analytic Hierarchy Process (AHP) were then used to prioritize these needs. Quality Function Deployment (QFD) was used to translate them into design elements, and Axiomatic Design (AD) was used to map functional requirements to design parameters. Results show that the integrated CTA-QFD-AD approach effectively identifies functional requirements and safety design elements. Optimizing key factors, such as ergonomic dimensions, spatial layout, Color-Material-Finish (CMF), environmental interfaces (lighting, noise, vibration), and tool/information interfaces, can significantly improve human-machine efficiency and ensures rescue safety.