Vehicle transport is an important part of logistics transport. It is of great significance to study the response of cargoes in the process of vehicle transport. Considering the coupling effect between cargo and vehicle bottom，an 11-degree-of-freedom vehicle-cargo coupling model is established. The relationship between three-way response is compared，and the influence of different road levels and cargo-related parameters （load，stiffness，damping） on the system response is taken into consideration. The results show that the coupling effect of vehicle-cargo significantly affects the system response. The influence of rotation in transportation cannot be ignored. The vibration response of cargo increases with a decrease of load，stiffness and damping. The worse the road condition is，the bigger the vibration response of cargo and vehicle bottom will be. The research results are of great significance and value for the design of vehicle-cargo transportation system.