To study the wind effect characteristics of super high-rise buildings in different incoming flows under the fluid-structure interaction effect，a full-scale numerical wind tunnel simulation of Pingan Financial Building in Shenzhen is carried out using the detached eddy simulation （DES），established the aeroelastic model. A new turbulent fluctuating flow field generation method named the discretizing and synthesizing random flow generator （DSRFG） is used to simulate the turbulent flows of the atmospheric boundary layer and the uniform flows. The wind pressure and wind-induced response results of the model are obtained. The calculated results are compared with the corresponding data from wind tunnel tests and field measurements to verify the accuracy of the numerical simulation. The analysis shows that the wind pressure of the building under turbulent incoming flow obtained from the DES is consistent with the distribution trend of wind tunnel test and field measurement results. The distribution of the mean wind pressure coefficient of the building under both conditions is similar，and the fluctuating wind pressure coefficient on the windward side under turbulent incoming flow is larger than that under uniform incoming flow. In addition，the cross-wind acceleration response is larger under turbulent incoming flow than that under uniform incoming flow，and the acceleration response power spectrum shows three peaks and the displacement response power spectrum shows two peaks under uniform incoming flow，while the turbulent incoming flow only shows a single peak. The acceleration response power spectrum shows three peaks and displacement response power spectrum shows double peaks under uniform incoming flow with only single peak under turbulent incoming flow. In the flow field，the wind velocity is more uniform in the uniform incoming flow than in the turbulent incoming flow，the wake vortex is flatter and narrower，and the overall vorticity magnitude is smaller.