Objective To comprehensively analyse the research status and hotspots of sinomenine by using bibliometric methods, and provide theoretical guidance for the future in-depth research and application of sinomenine. Methods A total of two databases of China Knowledge Network (CNKI) and Web of Science (WOS) were searched using sinomenine as the keyword, and the literature was imported into NoteExpress literature management software for screening. The analysis employed tools such as Excel, CiteSpace, and VOSviewer to visualize the current status of domestic and international research on sinomenine across various dimensions, including publication trends and national distribution, publishing institutions, publishing authors and keywords. Results A total of 710 Chinese and 471 English literature were retrieved that met the requirements. The research of sinomenine is mainly in China, and the international attention has also increased year by year in recent years, and the overall research has shown a continuous development trend. The core team of sinomenine research has been initially formed, and the cooperation is mostly carried out within the institution or in the same region, with less cross-regional cooperation. Both Chinese and English literature in the field of sinomenine focus on the pharmacological effects and mechanisms of sinomenine, such as anti-arthritis, while Chinese literature also focuses on the extraction and separation of sinomenine, quality standards, and formulation development. Conclusion The research of sinomenine is still in the limelight, and multi-omics-driven mechanism analysis, precision medicine-orientated dosage form innovation, and the expansion of new indications may be the hot spots of sinomenine research in the future. In addition, the research of sinomenine should strengthen multidisciplinary co-operation and apply new technologies in order to fully explore the potential of sinomenine.

sinomenine  /  bibliometrics  /  visual analysis  /  CiteSpace  /  VOSviewer  /  rheumatoid arthritis