Ligustri Lucidi Fructus, the dried mature fruit of Ligustrum lucidum Ait., has the effects of nourishing the liver and kidney and improving eyesight and blackening hair. It can be used to treat dizziness, tinnitus, soreness and weakness of the waist and knees, and premature graying of hair and beard. Studies have shown that Ligustri Lucidi Fructus contains a variety of active components such as triterpenoids, phenolic glycosides, sesquiterpenoids and flavonoids, and has multiple pharmacological effects including antioxidation, anti-aging, immune regulation, liver protection and lipid reduction, anti-inflammation and anti-tumor. The processing of Ligustri Lucidi Fructus has a long history and diverse methods, such as wine-making, salt-making and vineging-making, etc. Different processing methods may alter the nature, taste, meridian tropism and active ingredients of drugs, directly affecting their clinical efficacy and indications. Ligustri Lucidi Fructus, as a resource that can be used both as medicine and food, has relatively high safety. It can be used to treat various diseases such as hair loss, menstrual disorders, chronic hepatitis, diabetic nephropathy and cancer. This article systematically reviews for the first time the research progress made in the pharmacological components and extraction, pharmacological effects and mechanisms, processing methods and efficacy, formula compatibility and application of Ligustri Lucidi Fructus. It innovatively proposes the future research directions and challenges, to provide reference and inspiration for Ligustri Lucidi Fructus research.

Ligustri Lucidi Fructus  /  triterpenoids  /  phenolic glycosides  /  sesquiterpenoids  /  flavonoids  /  antioxidation, anti-aging  /  immune regulation  /  liver protection and lipid reduction  /  processing method  /  clinical application