“Chuzhuo Peiben” theory, proposed by nationally renowned Chinese medicine expert Professor Jia Yingjie, plays an important role in guiding the treatment of prostate cancer with traditional Chinese medicine. This article reviews the theory from the perspectives of theoretical interpretation, evidence integration, and paradigm construction. It systematically elucidates the dynamic pathogenesis model of “deficiency of the primordial foundation-coagulation of cancerous turbidity” and demonstrates the core logic of the strategy “tonifying the spleen surpasses tonifying the kidney” in circumventing androgen-related risks and remodeling the tumor microenvironment. In terms of clinical practice, it analyzes the staging-based dynamic treatment system centered around the “Jianpi Lishi Huayu Formula” and evaluates its synergistic value in combined therapy for “enhancing efficacy and reducing toxicity” and “delaying drug resistance.” At the mechanistic level, it integrates multidisciplinary evidence to construct a stereoscopic action network that spans from “multi-target synergistic prediction” to “core pathway experimental validation” and further to “tumor immune microenvironment remodeling,” thereby clarifying the biological basis of integrative intervention. The review also summarizes three core paradigmatic values of TCM intervention. In response to current research challenges, it proposes strategies such as designing prospective platform trials, applying multi-omics technologies, and constructing TCM-specific core outcome sets to promote the development of this field toward evidence-based and precision medicine paradigms.

prostate cancer  /  Chuzhuo Peiben  /  Jianpi Lishi Huayu Formula  /  treatment based on spleen theory  /  integrative medicine