Chinese medicine formulas (CMF) are the core means of clinical treatment in traditional Chinese medicine (TCM). As a key component of CMF, dosage forms can exert a decisive impact on the exertion of efficacy by altering the absorption, distribution, metabolism, and excretion processes of drugs. “Same prescription, different dosage forms” refers to the diverse dosage forms formed by processing the same prescription through different preparation technologies, and its phenomenon of “different effects” has become a research hotspot in the field of TCM and a focus of clinical attention. Centering on “same prescription, different dosage forms, different effects”, this paper first constructs a complete logical chain of “differences in dosage form and preparation technology-changes in chemical composition profiles-differentiation of in vivo pharmacokinetic-differences in pharmacodynamic and clinical efficacy”. It systematically sorts out the differences of TCM with “same prescription, different dosage forms” in chemical composition, pharmacokinetics, in vitro activity, pharmacodynamics, clinical application and adverse reactions. It clarifies that the core of these differences lies in the fact that preparation technologies affect chemical composition profiles and dissolution behaviors, thereby significantly altering pharmacokinetic characteristics and tissue distribution patterns, and ultimately leading to the differentiation of pharmacodynamic and clinical application. By establishing this logical chain, this paper aims to provide theoretical support for the precise design of TCM dosage forms, the improvement of quality standards, and the rational clinical drug selection, so as to promote the high-quality development of TCM with “same prescription, different dosage forms” in the process of precision medicine and internationalization.

same prescription, different dosage forms  /  dosage form technology  /  differential analysis  /  clinical application  /  precision medication