Objective To explore the cross-regional and multi-dimensional cooperation of global traditional Chinese medicine (TCM) researchers in the field of research on the TCM Corydalis yanhusuo from 2000 to 2024, and to sort out the research hotspots, frontier trends and regional distribution of research topics, so as to provide reference for the subsequent research on C. yanhusuo. Methods Literature on C. yanhusuo was retrieved from databases such as China National Knowledge Infrastructure (CNKI), Wanfang, VIP, Web of Science (WOS), and PubMed. The bibliometric software Coocation (COOC20.0) combined with VOSviewer 1.6.20 was used to conduct a visual analysis from multiple dimensions, including the number of publications, core authors, prolific institutions, keyword co-occurrence, and new word discovery, to construct a knowledge map of research hotspots and frontiers for C. yanhusuo. Results Since the 21st century, the number of papers published on C. yanhusuo research at home and abroad has gradually increased, and China is the core country for C. yanhusuo research. Major universities and research institutes in China are the main institutions for C. yanhusuo research, and the scope of cooperation exists in various TCM research units and related enterprises. English publications on C. yanhusuo are mostly contributed by Chinese research institutions, with hotspots concentrating on isolation and structural elucidation of alkaloid active components, establishment of quality assessment methods, and evaluation of alkaloid activity mechanisms. Conclusion Research on C. yanhusuo has entered a stage of diversified and in-depth development. In the future, it is expected that cutting-edge technologies such as artificial intelligence and multi-omics will be applied to the research on C. yanhusuo targets, mechanisms of action, and compound medication rules.

Corydalis yanhusuo W. T. Wang  /  bibliometrics  /  visualization analysis  /  hotspots and hot frontiers  /  knowledge map