Zebrafish are a critical model organism for investigating liver disease mechanisms and drug discovery because of their embryonic transparency and genetic manipulability, as well as their possession of a structurally and functionally conserved liver highly homologous to mammals. This review systematically summarizes methodologies for establishing zebrafish models of liver injury, hepatic fibrosis, and hepatocellular carcinoma, and focuses on exploring the therapeutic effects of traditional Chinese medicine (TCM) components in ameliorating liver injury, counteracting fibrogenesis, and inhibiting tumorigenesis,with the aims of providing novel perspectives and methodologies for advancing the application of zebrafish models in hepatopathology research and promoting TCM-based interventions for liver diseases.

zebrafish  /  liver injury  /  hepatic fibrosis  /  hepatocellular carcinoma  /  traditional Chinese medicine