The direct incorporation of crude drug powders into traditional Chinese medicine preparations represents a distinctive approach. While this method has unique advantages in preserving the full spectrum of herbal constituents and embodying the principle of “drug-excipient combination”, it also presents challenges such as microbial contamination, poor formulation formability, low dissolution rates of active ingredients, and difficulties in quality control. This paper statistically analyzes the distribution of crude drug powder formulations in the 2025 edition of the Chinese Pharmacopoeia, examines the application characteristics of crude drug powders in pharmaceuticals, and systematically reviews existing key issues. Furthermore, it explores solution strategies from dimensions including sterilization technology, powder properties modification, ultrafine grinding (particle design), and online detection. It also outlines future research directions, aiming to provide references for process optimization and quality enhancement of crude drug powder formulations.

crude drug powders  /  Chinese patent medicine  /  drug-excipient combination  /  powder properties  /  particle design