Objective A comprehensive analysis of the research hotspots and prospective trends of Croton tiglium from the perspectives of knowledge graphs and global patents is conducted to provide theoretical basis and reference direction for clinical practice and subsequent in-depth exploration of C. tiglium. Methods C. tiglium was used as the keyword to search four databases: CNKI, Wanfang, VIP, and Web of Science (WOS), and the literature was imported into the NoteExpress literature management software for duplication checking and screening. Excel, CiteSpace, VOSviewer and other softwares were used to conduct a visual analysis of the current status and development trends of C. tiglium research at home and abroad from the dimensions of publication trends, publishing countries, institutions, authors, and keywords. The Incopat patent database was used to search and analyze C. tiglium-related global patent applications from aspects such as patent application trends, global geographical distribution, patent applicants and patent technology fields. Results A total of 1 320 Chinese literature and 1 528 English literature that met the criteria were retrieved. After a preliminary search, a total of 11 004 patents were obtained in the Incopat patent database. After the merger process, 5 196 patents were finally retained. Among them, there are 2 346 domestic patents, accounting for 45.15% of the total, occupying a leading position. In general, the research heat in the field of C. tiglium continues to rise, the number of Chinese and English publications is comparable, and the academic influence at home and abroad is balanced. Among them, the United States has the highest number of publication volume in the world, and China is in the forefront, which are important research force in this field. In terms of scientific research cooperation, Chinese medicine colleges and affiliated medical institutions are the main body at home, with a single research structure and loose institutional cooperation, and there are obvious research barriers. International research relies on transnational scientific research subjects, with close cooperation networks and mature collaboration systems. In terms of research content, the domestic focus is on the traditional pharmacology and clinical application of C. tiglium, with an emphasis on the inheritance of traditional medicinal properties. The international focus is on fundamental and cutting-edge research such as active ingredients and mechanisms of action On the whole, C. tiglium research continues to break through the traditional category, relying on multidisciplinary cross to achieve innovative development, forming a development trend of inheritance and innovation. Conclusion Research in the field of C. tiglium is constantly expanding and deepening. Its research paradigm is undergoing a significant transformation, gradually shifting from the application of traditional Chinese medicine to multi-disciplinary interdisciplinary research and in-depth analysis of molecular mechanisms. China dominates the patent layout among various countries in the C. tiglium field. However, its patent system has significant weaknesses, mainly manifested in the premature expiration of a large number of patents, low technology industrialization, and insufficient commercial expansion capabilities. The research hotspots in Chinese literature focus on the anti-inflammatory pharmacological effects and processing techniques for reducing toxicity of C. tiglium, gradually extending to agricultural applications. Meanwhile, English research hotspots are concentrated on antioxidant activity, chemical taxonomy, and natural product chemistry, with antioxidant research showing significant growth in recent years.

Croton tiglium L.  /  CiteSpace  /  VOSviewer  /  knowledge graph  /  patent layout  /  processing to reduce toxicity  /  anti-inflammatory