Myocardial fibrosis (MF) is a key pathological feature following myocardial infarction (MI). This condition leads to myocardial stiffening and impaired cardiac pumping, ultimately resulting in complications including arrhythmias, heart failure, and cardiac rupture. Currently, interventions such as chemical drugs and surgery play an important role in the treatment of post-MI MF. However, they are still limited by suboptimal prognoses and high medical costs. Meanwhile, traditional Chinese medicine (TCM) has demonstrated potential value in this area, owing to its holistic regulation and multi-target therapeutic effects. This review provides a systematic overview of the pathological mechanisms underlying MF after MI and the preventive and therapeutic strategies of TCM for this disease. It aims to provide references for future clinical research and guide drug development efforts.

myocardial fibrosis  /  myocardial infarction  /  signal pathway  /  traditional Chinese medicine  /  mechanism of action