Objective To explore the research status, trends and hotspots of plant-derived exosomes (PDEs) using bibliometric visualization analysis, so as to provide a theoretical basis for their basic research and practical applications. Methods Utilizing CiteSpace, VOSviewer, and Scimago Graphica software, we conducted a comprehensive visualization analysis of Chinese and English literature on PDEs indexed in the China National Knowledge Infrastructure (CNKI) and the Web of Science Core Collection (WOSCC). The analysis encompassed publication trends, geographical distribution, institutional collaboration networks, author contributions, and keyword co-occurrence to identify research frontiers and evolving trajectories in PDEs research. Results A total of 2 815 eligible publications were included in this study, comprising 160 Chinese-language publications (5.68%) and 2 655 English-language publications (94.32%). Research activity in the PDEs field is predominantly concentrated in China and the United States, with global academic attention demonstrating a consistent annual increase. Institutional network analysis revealed distinct modular collaboration patterns, with Chinese institutions—including the Chinese Academy of Sciences, Zhejiang University, Capital Medical University, and Nanjing University of Chinese Medicine—alongside international institutions such as the University of California and the University of Illinois, occupying central positions in collaboration networks. High-frequency keyword co-occurrence analysis identified current research focal points, including PDEs derived from sources such as Jianghuang (Curcumae Longae Rhizoma), Renshen (Ginseng Radix et Rhizoma), tea, Gouqi (Lycii Fructus), and Machixian (Portulacae Herba), with investigations concentrating on molecular mechanisms underlying skin wound healing, neuroprotective effects, oncological therapy, anti-inflammatory and antioxidant activities, and blood-brain barrier modulation. Additionally, sustained research attention is directed toward applied domains including extraction and purification methodologies, establishment of quality evaluation standards, and the development of PDEs as drug delivery vehicles. Conclusion PDEs demonstrate substantial research potential in neuroprotection, oncological therapy, and wound healing applications. Future research trajectories will likely focus on optimizing extraction and purification protocols for PDEs from diverse botanical sources, developing novel formulations tailored to precision medicine requirements, and expanding their therapeutic indications. Furthermore, strengthening interdisciplinary collaboration and integrating emerging technologies will be essential for fully realizing the translational potential of PDEs.

plant-derived exosomes  /  bibliometrics  /  CiteSpace  /  VOSviewer  /  Scimago Graphica  /  wound healing  /  nerve protection  /  antitumor  /  anti-inflammatory  /  anti-oxidant  /  drug delivery