Enzymatically modified isoquercitrin (EMIQ) is a highly water-soluble flavonoid derivative produced through enzymatic glycosylation of isoquercitrin. Compared with quercetin and rutin, EMIQ exhibits markedly improved bioavailability. A growing body of research has demonstrated that EMIQ possesses a broad spectrum of pharmacological activities, including antioxidant, anti-inflammatory, anti-allergic, cardiovascular-protective, and muscle-enhancing effects. In addition, EMIQ can precisely regulate glucose and lipid metabolism, primarily through activation of the AMPK signaling pathway. Both animal experiments and clinical studies have confirmed its safety and reliability, and EMIQ has been approved for use as a food additive in Japan and the United States. This article provides a comprehensive review of the structural features, physicochemical properties, preparation methods, pharmacological activities, and safety evaluations of EMIQ, with the aim of offering a solid theoretical foundation and practical guidance for future research and industrial development of this compound.

flavonoid compounds  /  enzymatically modified isoquercitrin  /  glycosylation modification  /  antioxidant  /  anti-inflammatory  /  anti-allergy  /  cardiovascular protection  /  application value