Chronic heart failure (CHF) is a cardiovascular end syndrome with high prevalence, high mortality and high re-hospitalization rate, and traditional Chinese medicine (TCM) injections have significant potential in the treatment of CHF because of their combination of TCM evidence-based features and rapid onset of action. Based on ten years of research, this paper systematically investigates the pharmacodynamic material basis and action characteristics of 30 TCM injections to fill the gap of systematic summarization in this field. The study classified TCM injections into three categories according to TCM diagnosis: Activating blood and resolving stasis, replenishing qi and nourishing yin, and warming yang and excreting water. Activating blood and resolving stasis TCM injections can improve microcirculation and inhibit myocardial fibrosis and inflammation; replenishing qi and nourishing yin TCM injections focuses on regulating myocardial energy metabolism and mitochondrial function; warming yang and excreting water TCM injections can regulate intestinal bacterial flora, improve the “intestinal-cardiac axis” and inhibit iron death, etc. The study is the first to integrate single and compound TCM injections, revealing the advantages of TCM injections in multi-component and multi-target interventions in the complex pathology of CHF. It provides systematic evidence on the pharmacodynamic substances, mechanism of action, and clinical application for the clinical treatment of CHF using integrated Chinese and Western medicine, and provides new ideas for the precise identification of drugs and innovative treatment strategies.

traditional Chinese medicine injection  /  chronic heart failure  /  syndrome differentiation and treatment  /  combination of traditional Chinese and Western medicine  /  activating blood and resolving stasis  /  replenishing qi and nourishing yin  /  warming yang and excreting water